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Malassezia Fungemia, Antifungal Susceptibility Testing and Epidemiology of Nosocomial Infections

  • Chapter
Malassezia and the Skin

Core Messages

Malassezia catheter-related fungemia, and invasive infections in critically ill, premature neonates and immunocompromised individuals of all ages are issues addressed in relation to risk factors, host-pathogen interactions, pathogenesis, management, and outcome. The epidemiology of drug resistance of isolates from deep tissues, biological fluids, and skin is highlighted by assessing Malassezia susceptibility to conventional antifungals, synthetic, and naturally occurring compounds. Yet, lack of stan­dardization for Malassezia susceptibility testing restricts associations of in vitro with in vivo responses to antifungals. The chapter also describes the capacity of PCR fingerprinting, pulsed field gel electrophoresis (PFGE), and amplified fragment length polymorphism (AFLP) analysis to dependably identify nosocomial outbreaks, but concludes that robust analytical methods such as multilocus sequence typing (MLST) would be required to resolve global Malassezia epidemiological issues.

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Authors and Affiliations

  1. Mycology Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, 115 27, Greece

    Aristea Velegraki

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  1. Athanasios Tragiannidis
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  2. Andreas Groll
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  3. Aristea Velegraki
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  4. Teun Boekhout
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Correspondence to Aristea Velegraki .

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Editors and Affiliations

  1. Centraalbureau voor Schimmelcultures, Uppsalalaan 8, 3584, CT, Utrecht, The Netherlands

    Teun Boekhout PhD

  2. Department of Dermatology and Andrology, Justus Liebig University Giessen, Gaffykstrasse 14, 35385, Giessen, Germany

    Peter Mayser MD

  3. INSERM, 5 rue de la Huchette, 61400, Mauves sur Huisne, France

    Eveline Guého-Kellermann PhD

  4. Mycology Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece

    Aristea Velegraki PhD (Professor) (Professor)

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Tragiannidis, A., Groll, A., Velegraki, A., Boekhout, T. (2010). Malassezia Fungemia, Antifungal Susceptibility Testing and Epidemiology of Nosocomial Infections. In: Boekhout, T., Mayser, P., Guého-Kellermann, E., Velegraki, A. (eds) Malassezia and the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03616-3_8

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