Abstract
Remembering the past is crucially important for cognitive functions, such as anticipating and planning future activities or thinking about one’s own self. In Tulving’s hierarchy of long-term memory systems, episodic memory is the highest one that is most likely uniquely human. One of the characteristics of episodic memory is the ability to mentally travel into the past and the future. Several brain structures are fundamentally involved in successful acquisition and retrieval of episodic memories. In particular, limbic regions and parts of the prefrontal cortex are associated with specific facets of episodic memory, i.e. processing the emotional connotation of personal experiences and self-relevant information. Additionally, other brain regions have important supportive functions in memory encoding and retrieval. Specifically, the dorsolateral prefrontal cortex is engaged in learning strategies and in metacognitive processes necessary for successfully remembering information stored in long-term memory. Both studies with brain damaged patients and investigations employing functional neuroimaging techniques have provided insights into the neural correlates that associate thinking and memory.
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Addis DR, McAndrews MP (2006) Prefrontal and hippocampal contributions to the generation and binding of semantic associations during successful encoding. Neuroimage 33:1194-1206
Atance CM, O’Neill DK (2001) Episodic future thinking. Trends Cogn Sci 5:533-539
Atkinson RC, Shiffrin RM (1968) Human memory: a proposed system and its control processes. In: Spence KW, Spence JT (eds) The psychology of learning and motivation: advances in research and theory, vol 2. Academic Press, New York, pp 89-195
Babb SJ, Crystal JD (2006) Episodic-like memory in the rat. Curr Biol 16:1317-1321
Baddeley AD (1986) Working memory. University Press, Oxford
Baddeley AD (2000) The episodic buffer: A new component of working memory? Trends Cogn Sci 4:417-423
Binder JR, Bellgowan PS, Hammeke TA, Possing ET, Frost JA (2005) A comparison of two FMRI protocols for eliciting hippocampal activation. Epilepsia 46:1061-1070
Bird CM, Shallice T, Cipolotti L (2007) Fractionation of memory in medial temporal lobe amnesia. Neuropsychologia 45:1160-1171
Blumenfeld RS, Ranganath C (2006) Dorsolateral prefrontal cortex promotes long-term memory formation through its role in working memory organization. J Neurosci 26:916-925
Brand M (2007) Cognitive profile of patients with alcoholic Korsakoff’s syndrome. Int J Disabil Hum Dev 6:161-170
Brand M, Fujiwara E, Borsutzky S, Kalbe E, Kessler J, Markowitsch HJ (2005) Decision-making deficits of Korsakoff patients in a new gambling task with explicit rules: associations with executive functions. Neuropsychology 19:267-277
Brand M, Kalbe E, Fujiwara E, Huber M, Markowitsch HJ (2003) Cognitive estimation in patients with probable Alzheimer’s disease and alcoholic Korsakoff patients. Neuropsychologia 41:575-584
Brand M, Markowitsch HJ (2003) The principle of bottleneck structures. In: Kluwe RH, Lüer G, Rösler F (eds) Principles of learning and memory. Birkhäuser, Basel, pp 171-184
Brand M, Markowitsch HJ (2006) Memory processes and the orbitofrontal cortex. In: Zald D, Rauch S (eds) The orbitofrontal cortex. Oxford University Press, Oxford, pp 285-306
Brand M, Markowitsch HJ (2008) The role of the prefrontal cortex in episodic memory. In: Dere E, Huston JP, Easton A (eds) Handbook of episodic memory. Elsevier, Amsterdam, pp 317-342
Brokate B, Hildebrandt H, Eling P, Fichtner H, Runge K, Timm C (2003) Frontal lobe dysfunctions in Korsakoff’s syndrome and chronic alcoholism: continuity or discontinuity? Neuropsychology 17:420-428
Buckner RL (2003) Functional-anatomic correlates of control processes in memory. J Neurosci 23:3999-4004
Cabeza R, Dolcos F, Graham R, Nyberg L (2002) Similarities and differences in the neural correlates of episodic memory retrieval and working memory. Neuroimage 16:317-330
Cabeza R, Grady LC, Nyberg L, McIntosh RA, Tulving E, Kapur S, Jennings MJ, Houle S, Craik MIF (1997) Age-related differences in neural activity during memory encoding and retrieval: A positron emission tomography study. J Neurosci 17:391-400
Cabeza R, Nyberg L (2000) Imaging cognition II: An empirical review of 275 PET and fMRI studies. J Cogn Neurosci 12:1-47
Cabeza R, Prince SE, Daselaar SM, Greenberg DL, Budde M, Dolcos F, LaBar DL, Rubin DC (2004) Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm. J Cogn Neurosci 16:1583-1594
Cabeza R, St Jacques P (2007) Functional neuroimaging of autobiographical memory. Trends Cogn Sci 11:219-227
Cahill L (2000) Modulation of long-term memory in humans by emotional arousal: adrenergic activation and the amygdala. In: Aggleton JP (ed) The amygdala: a functional analysis. Oxford University Press, Oxford, pp 425-446
Cahill L, Haier RJ, White NS, Fallon J, Kilpatrick L, Lawrence C, Potkin SG, Alkire MT (2001) Sex-related differences in amygdala activity during emotionally influenced memory storage. Neurobiol Learn Mem 75:1-9
Clayton NS, Bussey TJ, Dickinson A (2003) Can animals recall the past and plan for the future? Nature Rev Neurosci 4:685-691
Corcoran R, Frith CD (2003) Autobiographical memory and theory of mind: evidence of a relationship in schizophrenia. Psychol Med 33:897-905
Corkin S (2002) What’s new with the amnesic patient H.M.? Nature Rev Neurosci 3:153-160
Dere E, Kart-Teke E, Huston JP, De Souza Silva MA (2006) The case for episodic memory in animals. Neurosci Biobehav Rev 30:1206-1224
Elliott R (2003) Executive functions and their disorders. Br Med Bull 65:49-59
Fink GR, Markowitsch HJ, Reinkemeier M, Bruckbauer T, Kessler J, Heiss W-D (1996) Cerebral representation of one’s own past: neural networks involved in autobiographical memory. J Neurosci 16:4275-4282
Fossati P, Hevenor SJ, Lepage M, Graham SJ, Grady C, Keightley ML, Craik F, Mayberg H (2004) Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits. Neuroimage 22:1596-1604
Fujiwara E, Markowitsch HJ (2006) Brain correlates of binding processes of emotion and memory. In: Zimmer H, Mecklinger AM, Lindenberger U (eds) Binding in human memory - A neurocognitive perspective. Oxford University Press, Oxford, pp 379-410
Fuster JM (2006) The cognit: a network model of cortical representation. Int J Psychophysiol 60:125-132
Greicius MD, Krasnow B, Boyett-Anderson JM, Eliez S, Schatzberg AF, Reiss AL, Menon V (2003) Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study. Hippocampus 13:164-164
Haist F, Bowden Gore J, Mao H (2001) Consolidation of human memory over decades revealed by functional magnetic resonance imaging. Nature 4:1139-1145
Hassabis D, Kumaran D, Maguire EA (2007a) Using imagination to understand the neural basis of episodic memory. J Neurosci 27:14365-14374
Hassabis D, Kumaran D, Vann SD, Maguire EA (2007b) Patients with hippocampal amnesia cannot imagine new experiences. Proc Natl Acad Sci USA 104:1726-1731
Hassabis D, Maguire EA (2007) Deconstructing episodic memory with construction. Trends Cogn Sci 11:299-306
Herholz K, Ehlen P, Kessler J, Strotmann T, Kalbe E, Markowitsch HJ (2001) Learning face-name associations and the effect of age and performance: a PET activation study. Neuropsychologia 39:643-650
Hering KEK (1870, 30.05.1870). Über das Gedächtnis als eine allgemeine Function der organisirten Materie. Paper presented at the Kaiserliche Akademie der Wissenschaften, Wien
Jansma JM, Ramsey NF, de Zwart JA, van Gelderen P, Duyn JH (2007) fMRI study of effort and information processing in a working memory task. Hum Brain Mapp 28:431-440
Johnson SC, Baxter LC, Wilder LS, Pipe JG, Heiserman JE, Prigatano GP (2002) Neural correlates of self-reflection. Brain 125:1808-1814
Kane MJ, Engle RW (2002) The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: an individual-differences perspective. Psychon Bull Rev 9:637-671
Kircher TT, Weis S, Freymann K, Erb M, Jessen F, Grodd W, Heun R, Leube DT (2007) Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding. J Neurol Neurosurg Psychiatry 78:812-818
Kopelman MD (1995) The Korsakoff syndrome. Br J Psychiatry 166:154-173
Kumaran D, Maguire EA (2006) The dynamics of hippocampal activation during encoding of overlapping sequences. Neuron 49:617-629
Lepage M, Ghaffar O, Nyberg L, Tulving E (2000) Prefrontal cortex and episodic memory retrieval mode. Proc Natl Acad Sci USA 97:506-511
Levine B, Turner GR, Tisserand D, Hevenor SJ, Graham SJ, McIntosh AR (2004) The functional neuroanatomy of episodic and semantic autobiographical remembering: a prospective functional MRI study. J Cogn Neurosci 16:1633-1646
Lie CH, Specht K, Marshall JC, Fink GR (2006) Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test. Neuroimage 30:1038-1049
Markowitsch HJ (1988) Anatomical and functional organization of the primate prefrontal cortical system. In: Steklis HD, Erwin J (eds) Comparative primate biology, Vol. IV: Neurosciences. Alan R. Liss, New York, pp 99-153
Markowitsch HJ (1992) Intellectual functions and the brain. An historical perspective. Hogrefe and Huber Publs, Toronto
Markowitsch HJ (1994) Brain development and behavior. In: Husen T, Postlethwaite TN (eds) The international encyclopedia of education (Vol 2nd). Pergamon Press, Oxford, pp 552-554
Markowitsch HJ (2000) The anatomical bases of memory. In: Gazzaniga MS (ed) The new cognitive neurosciences, 2nd edn. The MIT Press, Cambridge, pp 781-795
Markowitsch HJ (2003a) Memory: disturbances and therapy. In: Brandt T, Caplan L, Dichgans J, Diener HC, Kennard C (eds) Neurological disorders; course and treatment, 2nd edn. Academic Press, San Diego, pp 287-302
Markowitsch HJ (2003b) Psychogenic amnesia. Neuroimage 20:S132-S138
Markowitsch HJ, Emmans D, Irle E, Streicher M, Preilowski B (1985) Cortical and subcortical afferent connections of the primate’s temporal pole: a study of rhesus monkeys, squirrel monkeys, and marmosets. J Comp Neurol 242:425-458
Markowitsch HJ, Tulving E (1994) Cognitive processes and cerebral cortical fundi: Findings from positron-emission tomography studies. Proc Natl Acad Sci USA 91:10507-10511
Markowitsch HJ, Vandekerckhove MM, Lanfermann H, Russ MO (2003) Engagement of lateral and medial prefrontal areas in the ecphory of sad and happy autobiographical memories. Cortex 39:643-665
Metzler-Baddeley C (2007) A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer’s disease and Parkinson’s disease with dementia. Cortex 43:583-600
Mimura M, Kinsbourne M, O’Connor M (2000) Time estimation by patients with frontal lesions and by Korsakoff patients. J Int Neuropsychol Soc 6:517-528
Miotto EC, Savage CR, Evans JJ, Wilson BA, Martins MG, Iaki S, Amaro EJ (2006) Bilateral activation of the prefrontal cortex after strategic semantic cognitive training. Hum Brain Mapp 27:288-295
Moscovitch M, Rosenbaum RS, Gilboa A, Addis DR, Westmacott R, Grady C, McAndrews MP, Levine B, Black S, Winocur G, Nadel L (2005) Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory. J Anat 207:35-66
Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, Panksepp J (2006) Self-referential processing in our brain-a meta-analysis of imaging studies on the self. Neuroimage 31:440-457
Nyberg L, McIntosh AR, Cabeza R, Habib R, Houle S, Tulving E (1996) General and specific brain regions involved in encoding and retrieval of events: what, where, and when. Proc Natl Acad Sci USA 93:11280-11285
Papez JW (1937) A proposed mechanism of emotion. Arch Neurol Psychiatry 38:725-743
Phelps ME (2006) Emotion and cognition: insights from studies of the human amygdala. Annu Rev Psychol 57:27-53
Phelps ME, LeDoux JE (2005) Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48:175-187
Piefke M, Fink GR (2005) Recollections of one’s own past: the effects of aging and gender on the neural mechanisms of episodic autobiographical memory. Anat Embryol 210:497-512
Piefke M, Weiss PH, Markowitsch HJ, Fink GR (2005) Gender differences in the functional neuroanatomy of emotional episodic autobiographical memory. Hum Brain Mapp 24:313-324
Piefke M, Weiss PH, Zilles K, Markowitsch HJ, Fink GR (2003) Differential remoteness and emotional tone modulate the neural correlates of autobiographical memory. Brain 126:650-668
Premack D (2007) Human and animal cognition: continuity and discontinuity. Proc Natl Acad Sci USA 104:13861-13867
Rand-Giovannetti E, Chua EF, Driscoll AE, Schacter DL, Albert MS, Sperling RA (2006) Hippocampal and neocortical activation during repetitive encoding in older persons. Neurobiol Aging 27:173-182
Ranganath C, Johnson MK, D’Esposito M (2003) Prefrontal activity associated with working memory and episodic long-term memory. Neuropsychologia 41:378-389
Rugg MD, Otten LJ, Henson RNA (2002) The neural basis of episodic memory: evidence from functional neuroimaging. Philos Trans R Soc B-Biol Sci 357:1097-1110
Schacter DL, Addis DR, Buckner RL (2007) Remembering the past to imagine the future: the prospective brain. Nature Rev Neurosci 8:657-661
Schmitz TW, Johnson SC (2006) Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networks. Neuroimage 30:1050-1058
Schmitz TW, Kawahara-Baccus TN, Johnson SC (2004) Metacognitive evaluation, self-relevance, and the right prefrontal cortex. Neuroimage 22:941-947
Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11-21
Skov-Rackette SI, Miller NY, Shettleworth SJ (2006) What-where-when memory in pigeons. J Exp Psychol Anim Behav Process 32:345-358
Staresina BP, Davachi L (2006) Differential encoding mechanisms for subsequent associative recognition and free recall. J Neurosci 26:9162-9172
Steinvorth S, Levine B, Corkin S (2005) Medial temporal lobe structures are needed to re-experience remote autobiographical memories: evidence from H.M. and W.R. Neuropsychologia 43:479-496
Suddendorf T, Corballis MC (2007) The evolution of foresight: What is mental time travel, and is it unique to humans? Behav Brain Sci 30:299-313
Summerfield C, Greene M, Wager T, Egner T, Hirsch J, Mangels J (2006) Neocortical connectivity during episodic memory formation. PLoS Biol 4:e128
Svoboda E, McKinnon MC, Levine B (2006) The functional neuroanatomy of autobiographical memory: a meta-analysis. Neuropsychologia 44:2189-2208
Tulving E (1972) Episodic and semantic memory. In: Tulving E, Donaldson W (eds) Organization of memory. Academic Press, New York, pp 381-403
Tulving E (1995) Organization of memory: Quo vadis? In: Gazzaniga MS (ed) The cognitive Neurosciences. MIT Press, Cambridge, pp 839-847
Tulving E (2002) Episodic memory: from mind to brain. Annu Rev Psychol 53:1-25
Tulving E (2005) Episodic memory and autonoesis: uniquely human? In: Terrace H, Metcalfe J (eds) The missing link in cognition: evolution of self-knowing consciousness. Oxford University Press, New York, pp 3-56
Tulving E, Kim A (2007) The medium and the message of mental time travel. Behav Brain Sci 30:334-335
Uncapher MR, Rugg MD (2005a) Effects of divided attention on fMRI correlates of memory encoding. J Cogn Neurosci 17:1923-1935
Uncapher MR, Rugg MD (2005b) Encoding and the durability of episodic memory: a functional magnetic resonance imaging study. J Neurosci 25:7260-7267
Vandekerckhove MMP, Markowitsch HJ, Mertens M, Woermann FG (2005) Bi-hemispheric engagement in the retrieval of autobiographical episodes. Behav Neurol 16:203-210
Velanova K, Jacoby LL, Wheeler ME, McAvoy MP, Petersen SE, Buckner RL (2003) Functional-anatomic correlates of sustained and transient processing components engaged during controlled retrieval. J Neurosci 23:8460-8470
Viard A, Piolino P, Desgranges B, Chételat G, Lebreton K, Landeau B, Young A, De La Sayette V, Eustache F (2007) Hippocampal activation for autobiographical memories over the entire lifetime in healthy aged subjects: an fMRI study. Cereb Cortex 17:2453-2467
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Brand, M., Markowitsch, H.J. (2010). Thinking and Memory. In: Glatzeder, B., Goel, V., Müller, A. (eds) Towards a Theory of Thinking. On Thinking. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03129-8_10
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