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Microfluidic Devices and Their Applications to Lab-on-a-Chip

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Springer Handbook of Nanotechnology

Part of the book series: Springer Handbooks ((SHB))

Abstract

Various microfluidic components and their characteristics, along with the demonstration of two recent achievements of lab-on-chip systems are reviewed and discussed. Many microfluidic devices and components have been developed during the past few decades, as introduced earlier for various applications. The design and development of microfluidic devices still depend on the specific purposes of the devices (actuation and sensing) due to a wide variety of application areas, which encourages researchers to develop novel, purpose-specific microfluidic devices and systems. Microfluidics is the multidisciplinary research field that requires basic knowledge in fluidics, micromachining, electromagnetics, materials, and chemistry for various applications.

Among the various application areas of microfluidics, one of the most important is the lab-on-a-chip system. Lab-on-a-chip is becoming a revolutionary tool for many different applications in chemical and biological analyses due to its fascinating advantages (fast speed and low cost) over conventional chemical or biological laboratories. Furthermore, the simplicity of lab-on-a-chip systems will enable self-testing capability for patients or health consumers by overcoming space limitations.

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Abbreviations

AC:

alternating-current

AC:

amorphous carbon

AP:

alkaline phosphatase

CE:

capillary electrophoresis

CE:

constant excitation

COC:

cyclic olefin copolymer

DC:

direct-current

DNA:

deoxyribonucleic acid

DRIE:

deep reactive ion etching

EDP:

ethylene diamine pyrochatechol

EHD:

elastohydrodynamic

EO:

electroosmosis

EOF:

electroosmotic flow

GOD:

glucose oxidase

HF:

hydrofluoric

HNA:

hydrofluoric-nitric-acetic

IDA:

interdigitated array

MEMS:

microelectromechanical system

MHD:

magnetohydrodynamic

NMP:

no-moving-part

PAPP:

p-aminophenyl phosphate

PC:

polycarbonate

PDMS:

polydimethylsiloxane

PE:

polyethylene

PMMA:

poly(methyl methacrylate)

POCT:

point-of-care testing

PS:

polystyrene

RF:

radiofrequency

RIE:

reactive-ion etching

SMA:

shape memory alloy

TMAH:

tetramethyl ammonium hydroxide

bioMEMS:

biomedical microelectromechanical system

mTAS:

micro total analysis system

sPROM:

structurally programmable microfluidic system

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, University of Cincinnati, 45221, Cincinnati, OH, USA

    Chong H. Ahn

  2. Department of Electrical and Computer Engineering, Louisiana State University, 70803, Baton Rouge, LA, USA

    Jin-Woo Choi

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  1. Chong H. Ahn
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Correspondence to Chong H. Ahn or Jin-Woo Choi .

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  1. Ohio State University, Nanoprobe Laboratory for Bio- and Nanotechnology and Biomimetics (NLB2), 201 W. 19th Avenue, 43210-1142, Columbus, OH, USA

    Bharat Bhushan

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Ahn, C.H., Choi, JW. (2010). Microfluidic Devices and Their Applications to Lab-on-a-Chip. In: Bhushan, B. (eds) Springer Handbook of Nanotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02525-9_18

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