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Natural Killer Cells pp 125–152Cite as

Virus Interactions with NK Cell Receptors

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Abstract

Natural killer cells are among the first cells of the immune response to recognize and react to threats. They do so by surveying other cells for aberrant behavior such as altered expression of MHC class I, and molecules produced or induced by pathogens. As such, they are very important in host resistance to viral infection. Various unrelated viruses have evolved numerous evasion techniques in order to avoid detection by NK cells. The many immunoevasive techniques may be roughly divided into two main groups: camouflage of infected cells aimed at inhibitory receptors and obstruction of activating receptors. By differential downmodulation of MHC class I molecules and production of MHC class I homologues, viruses prevent CTL recognition and camouflage their presence from NK cells. Additionally, viruses have directed even greater attention towards preventing the engagement of activating receptors by interfering with the receptors per se or by down modulating their ligands and coactivating molecules, providing soluble competitors, modification and interference with translation of ligands.

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Authors and Affiliations

  1. Department of Histology and Embryology, Faculty of Medicine, Braće Branchetta 20, 51000, Rijeka, Croatia

    Vanda Juranić Lisnić, Iva Gašparović, Astrid Krmpotić & Stipan Jonjić

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  1. Vanda Juranić Lisnić
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  2. Iva Gašparović
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  3. Astrid Krmpotić
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  4. Stipan Jonjić
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Correspondence to Stipan Jonjić .

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  1. Lab. Immuno-Allergologie, Centre de Recherche Public, Val Fleuri 84, Luxembourg, 1526, Luxembourg

    Jacques Zimmer

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Lisnić, V.J., Gašparović, I., Krmpotić, A., Jonjić, S. (2010). Virus Interactions with NK Cell Receptors. In: Zimmer, J. (eds) Natural Killer Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02309-5_6

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