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HIV Interactions with Host Cell Proteins pp 125–146Cite as

Virological and Cellular Roles of the Transcriptional Coactivator LEDGF/p75

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 339))

Abstract

The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.

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Acknowledgements

We are grateful for support from N.I.H. grants 1SC2GM082301 to M. L. and AI77344 to E.M.P. We thank P. Spearman for editorial advice, and patience.

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Authors and Affiliations

  1. Department of Molecular Medicine, Department of Molecular Medicine and Division of Infectious Diseases, Mayo Clinic College of Medicine, Guggenheim 1811A, Rochester, MN, 55905, USA

    James Morrison & Eric M. Poeschla

  2. Biological Sciences Department, University of Texas, El Paso, TX, 79968-0519, USA

    Manuel Llano

Authors
  1. Manuel Llano
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  2. James Morrison
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  3. Eric M. Poeschla
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Correspondence to Eric M. Poeschla .

Editor information

Editors and Affiliations

  1. School of Medicine, Dept. Pediatrics, Emory University, Uppergate Drive NE., 2015, Atlanta, 30322, Georgia, USA

    Paul Spearman

  2. HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland, USA

    Eric O. Freed

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© 2009 Springer-Verlag Berlin Heidelberg

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Llano, M., Morrison, J., Poeschla, E.M. (2009). Virological and Cellular Roles of the Transcriptional Coactivator LEDGF/p75. In: Spearman, P., Freed, E. (eds) HIV Interactions with Host Cell Proteins. Current Topics in Microbiology and Immunology, vol 339. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02175-6_7

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