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Sex Hormones and Immunity to Infection pp 281–302Cite as

Sex, Pregnancy and Measles

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Abstract

The World Health Organization rescinded the recommendation that young children receive high-titer measles vaccine in 1992 following evidence that, in certain regions of the world, girls receiving this vaccine had increased mortality compared with those receiving standard-titer vaccines. It has been suggested that the high-titer vaccine might induce immunomodulation similar to that observed following wild-type measles virus infection. Additionally, maternal infection during pregnancy with malaria or HIV has been shown to reduce passive transfer of antimeasles antibodies to the fetus and lower the age at which infants become susceptible to measles. These data demonstrate that vaccine efficacy and adverse effects can vary between the sexes and this should be studied before new vaccines are widely used.

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Authors and Affiliations

  1. Department of Epidemiology and W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA

    William J. Moss

Authors
  1. Allison C. Brown
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  2. William J. Moss
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Correspondence to William J. Moss .

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Editors and Affiliations

  1. School of Public Health, Johns Hopkins Bloomberg, N. Wolfe Street 615, Baltimore, 21205, U.S.A.

    Sabra L. Klein

  2. Institute for Biomedical Sciences, University of Strathclyde, Taylor Street 27, Glasgow, G4 0NR, United Kingdom

    Craig Roberts

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Brown, A.C., Moss, W.J. (2010). Sex, Pregnancy and Measles. In: Klein, S., Roberts, C. (eds) Sex Hormones and Immunity to Infection. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02155-8_11

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