Abstract
Angiogenesis, the growth of new blood vessels from pre-existing ones, is crucial for the growth and development of many multicellular organisms and for the progression of many diseases such as cancer, macular degeneration, and diabetic retinopathy. The process of angiogenesis begins with a combination of highly controlled endothelial cell migration (tip cell phenotype) and proliferation (stalk cell phenotype) to form new immature blood vessels. These newly formed blood vessels, also termed “neovessels,” are then stabilized through recruitment of mural cells to generate a mature vascular network that is required for the metabolic demands of the underlying tissue, and provides a conduit through which the immune system functions. A delicate balance between positive and negative angiogenic regulators governs this complex process. In this chapter we will focus on the key signaling events that regulate angiogenesis both during development and in disease.
Keywords
- Vascular Endothelial Growth Factor
- Vascular Endothelial Growth Factor Expression
- Hereditary Hemorrhagic Telangiectasia
- Endothelial Cell Migration
- Vascular Endothelial Growth Factor Signaling
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Andrae J, Gallini R, Betsholtz C (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 22:1276–1312
Armulik A, Abramsson A, Betsholtz C (2005) Endothelial/pericyte interactions. Circ Res. 97:512–523
Bobik A (2006) Transforming growth factor-betas and vascular disorders. Arterioscler Thromb Vasc Biol. 26:1712–1720
Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med. 9:669–676
Ho QT, Kuo CJ (2007) Vascular endothelial growth factor: biology and therapeutic applications. Int J Biochem Cell Biol. 39:1349–1357
Holmes K, Roberts OL, Thomas AM, Cross MJ (2007) Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal. 19:2003–2012
Kerbel RS (2008) Tumor angiogenesis. N Engl J Med. 358:2039–2049
Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, Kuo CJ (2008) Attribution of Angiogenesis Phenotypes of the Murine Egfl7 Locus to the microRNA miR-126. Development. 135:3989–3993
Makinde T, Agrawal DK (2008) Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease. J Cell Mol Med. 12:810–828
Olofsson B, Jeltsch M, Eriksson U, Alitalo K (1999) Current biology of VEGF-B and VEGF-C. Curr Opin Biotechnol. 10:528–535
Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U (1996) Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci U S A. 93:2576–2581
Otrock ZK, Makarem JA, Shamseddine AI (2007) Vascular endothelial growth factor family of ligands and receptors: review. Blood Cells Mol Dis. 38:258–268
Pugh CW, Ratcliffe PJ (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 9:677–684
Roca C, Adams RH (2007) Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 21:2511–2524
Shibuya M (2006) Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. J Biochem Mol Biol. 39:469–478
Shibuya M, Claesson-Welsh L (2006) Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 312:549–560
Shibuya M, Ito N, Claesson-Welsh L (1999) Structure and function of vascular endothelial growth factor receptor-1 and -2. Curr Top Microbiol Immunol. 237:59–83
Silva R, D’Amico G, Hodivala-Dilke KM, Reynolds LE (2008) Integrins: the keys to unlocking angiogenesis. Arterioscler Thromb Vasc Biol. 28:1703–1713
Tammela T, Enholm B, Alitalo K, Paavonen K (2005) The biology of vascular endothelial growth factors. Cardiovasc Res. 65:550–563
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Mancuso, M.R., Kuo, C.J. (2010). Signaling in Normal and Pathological Angiogenesis. In: Sitaramayya, A. (eds) Signal Transduction: Pathways, Mechanisms and Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02112-1_9
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DOI: https://doi.org/10.1007/978-3-642-02112-1_9
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