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Signal Transduction: Pathways, Mechanisms and Diseases pp 219–236Cite as

Mitogen-Activated Protein Kinases and Their Scaffolding Proteins

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Abstract

Signaling pathways mediated by mitogen-activated protein kinases (MAPKs) are critically involved in the regulation of cell proliferation, differentiation, and apoptosis. A typical MAPK signaling pathway is organized as a three-tier MAPK module consisting of an upstream MAP kinase kinase kinase (MAP3K), a penultimate MAP kinase kinase (MAP2K), and the downstream MAP kinase (MAPK). The remarkable fidelity and context-specific signaling of MAPK modules are primarily due to the family of MAPK-specific scaffolding proteins that interact with the components of the MAPK module. By tethering the signaling partners in close proximity, the scaffolding proteins are critically involved in the spatiotemporal organization of the MAPK modules in addition to modulating the signaling outputs of the respective MAPK module. This chapter focuses on defining the diverse mechanisms by which different MAPKs and their scaffolding proteins interact and the significance of such interactions in the regulation of specific cellular responses.

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Acknowledgments

Studies presented in authors’ laboratories were supported by the National Institutes of Health Grants CA123233 (to D.N.D) and CA109820 (to E.P.R).

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Authors and Affiliations

  1. OU Cancer Institute, The University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA

    Danny N. Dhanasekaran

  2. Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N. Broad Street, Philadelphia, PA, 19140, USA

    E. Premkumar Reddy

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  1. Danny N. Dhanasekaran
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  2. E. Premkumar Reddy
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Correspondence to Danny N. Dhanasekaran .

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  1. Eye Research Institute, Oakland University, DHE 423, Rochester, 48309, USA

    Ari Sitaramayya

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Dhanasekaran, D.N., Reddy, E.P. (2010). Mitogen-Activated Protein Kinases and Their Scaffolding Proteins. In: Sitaramayya, A. (eds) Signal Transduction: Pathways, Mechanisms and Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02112-1_12

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