Skip to main content

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Transformed lymphoid cells are relatively large, usually with a round to oval nucleus with one or more nucleoli and basophilic cytoplasm as seen on a Wright-Giemsa type stain. They are like lymphocytes that have been exposed to a mitogen.

References

  1. Leblond V, Davi F, Charlotte F, Dorent R, Bitker MO, Sutton L, Gandjbakhch I, Binet JL, Raphael M. Posttransplant lymphoproliferative disorders not associated with Epstein—Barr virus: a distinct entity? J Clin Oncol. 1998;16:2052–9

    PubMed  CAS  Google Scholar 

  2. Nelson BP, Nalesnik MA, Bahler DW, Locker J, Fung JJ, Swerdlow SH. Epstein—Barr virusnegative post-transplant lymphoproliferative disorders—a distinct entity? Am J Surg Pathol. 2000;24:375–385

    Article  PubMed  CAS  Google Scholar 

  3. Swerdlow SH. T-cell and NK-cell posttransplantation lymphoproliferative disorders. Am J Clin Pathol. 2007;127:887–95

    Article  PubMed  Google Scholar 

  4. Kapelushnik J, Ariad S, Benharroch D, Landau D, Moser A, Delsol G, Brousset P. Post renal transplantation human herpesvirus 8-associated lymphoproliferative disorder and Kaposi's sarcoma. Br J Haematol. 2001;113:425–8

    Article  PubMed  CAS  Google Scholar 

  5. Frizzera G, Hanto DW, Gajl-Peczalska KJ, Rosai J, McKenna RW, Sibley RK, Holahan KP, Lindquist LL. Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res. 1981;41:4262–79

    PubMed  CAS  Google Scholar 

  6. Harris NL, Ferry JA, Swerdlow SH. Posttransplant lymphoproliferative disorders: summary of society for hematopathology workshop. Semin Diagn Pathol. 1997;14:8–14

    PubMed  CAS  Google Scholar 

  7. Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood. 1995;85:552–65

    PubMed  CAS  Google Scholar 

  8. Locker J, Nalesnik M. Molecular genetic analysis of lymphoid tumors arising after organ transplantation. Am J Pathol. 1989;135:977–87

    PubMed  CAS  Google Scholar 

  9. Nalesnik MA, Jaffe R, Starzl TE, Demetris AJ, Porter K, Burnham JA, Makowka L, Ho M, Locker J. The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol. 1988;133:173–92

    PubMed  CAS  Google Scholar 

  10. Shapiro RS, McClain K, Frizzera G, Gajl-Peczalska KJ, Kersey JH, Blazar BR, Arthur DC, Patton DF, Greenberg JS, Burke B, et al. Epstein—Barr virus associated B cell lymphoprolifera-tive disorders following bone marrow transplantation. Blood. 1988;71:1234–43

    PubMed  CAS  Google Scholar 

  11. Swerdlow SH. Classification of the posttransplant lymphoproliferative disorders: from the past to the present. Semin Diagn Pathol. 1997;14:2–7

    PubMed  CAS  Google Scholar 

  12. Swerdlow SH. Posttransplant lymphoproliferative disorders: a working classification. Curr Diagn Pathol. 1997;4:29–36

    Article  Google Scholar 

  13. Harris NL, Swerdlow SH, Frizzera G, Knowles DM. Post-transplant lymphoproliferative disorders. In: Jaffe ES, Harris NL, Stein H Vardiman JW, editors. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2001. p. 264–9

    Google Scholar 

  14. Swerdlow SH, Webber SA, Chadburn A, Ferry JA. Post-transplant lymphoproliferative disorders. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J and Vardiman JW, editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC; 2008

    Google Scholar 

  15. Wu TT, Swerdlow SH, Locker J, Bahler D, Randhawa P, Yunis EJ, Dickman PS, Nalesnik MA. Recurrent Epstein–Barr virus-associated lesions in organ transplant recipients. Hum Pathol. 1996;27:157–64

    Article  PubMed  CAS  Google Scholar 

  16. Bingler MA, Feingold B, Miller SA, Quivers E, Michaels MG, Green M, Wadowsky RM, Rowe DT, Webber SA. Chronic high Epstein—Barr viral load state and risk for late-onset post-transplant lymphoproliferative disease/lymphoma in children. Am J Transplant. 2008;8:442–5

    Article  PubMed  CAS  Google Scholar 

  17. Green M, Soltys K, Rowe DT, Webber SA, Mazareigos G. Chronic high Epstein–Barr viral load carriage in pediatric liver transplant recipients. Pediatr Transplant. 2009;13:319–23

    Article  PubMed  Google Scholar 

  18. Rowe DT, Webber S, Schauer EM, Reyes J, Green M. Epstein—Barr virus load monitoring: its role in the prevention and management of post-transplant lymphoproliferative disease. Transpl Infect Dis. 2001;3:79–87

    Article  PubMed  CAS  Google Scholar 

  19. Tsai DE, Douglas L, Andreadis C, Vogl DT, Arnoldi S, Kotloff R, Svoboda J, Bloom RD, Olthoff KM, Brozena SC, Schuster SJ, Stadtmauer EA, Robertson ES, Wasik MA, Ahya VN. EBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial. Am J Transplant. 2008;8:1016–24

    Article  PubMed  CAS  Google Scholar 

  20. Djokic M, Le Beau MM, Swinnen LJ, Smith SM, Rubin CM, Anastasi J, Carlson KM. Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities. Genes Chromosomes Cancer. 2006;45:313–8

    Article  PubMed  CAS  Google Scholar 

  21. Vakiani E, Nandula SV, Subramaniyam S, Keller CE, Alobeid B, Murty VV, Bhagat G. Cytogenetic analysis of B-cell posttransplant lymphoproliferations validates the World Health Organization classification and suggests inclusion of florid follicular hyperplasia as a precursor lesion. Hum Pathol. 2007;38:315–25

    Article  PubMed  Google Scholar 

  22. Craig FE, Johnson LR, Harvey SA, Nalesnik MA, Luo JH, Bhattacharya SD, Swerdlow SH. Gene expression profiling of Epstein–Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Diagn Mol Pathol. 2007;16:158–168

    Article  PubMed  CAS  Google Scholar 

  23. Vakiani E, Basso K, Klein U, Mansukhani MM, Narayan G, Smith PM, Murty VV, Dalla-Favera R, Pasqualucci L, Bhagat G. Genetic and phenotypic analysis of B-cell post-transplant lymphop-roliferative disorders provides insights into disease biology. Hematol Oncol. 2008; 26:199–211

    Article  PubMed  CAS  Google Scholar 

  24. Meru N, Davison S, Whitehead L, Jung A, Mutimer D, Rooney N, Kelly D, Niedobitek G. Epstein–Barr virus infection in paediatric liver transplant recipients: detection of the virus in post-transplant tonsillectomy specimens. Mol Pathol. 2001;54:264–9

    Article  PubMed  CAS  Google Scholar 

  25. Cesarman E, Chadburn A, Liu YF, Migliazza A, Dalla-Favera R, Knowles DM. BCL-6 gene mutations in posttransplantation lymphoproliferative disorders predict response to therapy and clinical outcome. Blood. 1998;92:2294–302

    PubMed  CAS  Google Scholar 

  26. Hsi ED, Singleton TP, Swinnen L, Dunphy CH, Alkan S. Mucosa-associated lymphoid tissuetype lymphomas occurring in post-transplantation patients. Am J Surg Pathol. 2000;24:100–6

    Article  PubMed  CAS  Google Scholar 

  27. Borenstein J, Pezzella F, Gatter KC. Plasmablastic lymphomas may occur as post-transplant lymphoproliferative disorders. Histopathology. 2007;51:774–7

    Article  PubMed  CAS  Google Scholar 

  28. Johnson LR, Nalesnik MA, Swerdlow SH. Impact of Epstein—Barr virus in monomorphic B-cell posttransplant lymphoproliferative disorders: a histogenetic study. Am J Surg Pathol. 2006;30:1604–12

    Article  PubMed  Google Scholar 

  29. Chan WY, Chan AB, Liu AY, Chow JH, Ng EK, Chung SS. Chromosome 11 copy number gains and Epstein—Barr virus-associated malignancies. Diagn Mol Pathol. 2001;10:223–7

    Article  PubMed  CAS  Google Scholar 

  30. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008

    Google Scholar 

  31. Callan MF, Steven N, Krausa P, Wilson JD, Moss PA, Gillespie GM, Bell JI, Rickinson AB, McMichael AJ. Large clonal expansions of CD8 + T cells in acute infectious mononucleosis. Nat Med. 1996;2:906–11

    Article  PubMed  CAS  Google Scholar 

  32. Ranganathan S, Webber S, Ahuja S, Jaffe R. Hodgkin-like posttransplant lymphoproliferative disorder in children: does it differ from posttransplant Hodgkin lymphoma? Pediatr Dev Pathol. 2004;7:348–60.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Swerdlow, S.H. (2010). Pathology. In: Dharnidharka, V.R., Green, M., Webber, S.A. (eds) Post-Transplant Lymphoproliferative Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01653-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-01653-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01652-3

  • Online ISBN: 978-3-642-01653-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics