Abstract
The life of a cell relies on multiple mechanisms for regulating the diverse reactions that constitute metabolism, as has been previously explained. Some mechanisms are provided by the intrinsic properties of enzymes, such as allosteric enzymes. Others stem from the spatial organisation that allows modulation of enzymatic activity, as with membrane enzymes and multi-enzyme complexes. In these complexes the product of an enzyme reaction is frequently the substrate for the subsequent reaction. In this respect, the metabolic pathway can be considered to be an organised system.
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Bibliography
Reviews
Hess B. & Boiteux A. –1971– Oscillatory phenomena in biochemistry, in Annu. Rev. Biochem. 40, 237–258.
Silman I.H. & Katchalski E. –1966– Water-insoluble derivatives of enzymes, antigens and antibodies, in Annu. Rev. Biochem. 35, 873–908.
Srere P.A. –1988– Complexes of sequential metabolic enzymes, in Annu. Rev. Biochem. 56, 89–124.
Specialised Articles
Blobe C.G., Stribling D.S., Fabbro D., Stabel S. & Hannun Y.A. –1996– J. Biol. Chem. 271, 15823.
Cohen S.M. –1989– Methods Enzymol. 177, 417.
Couée I. & Tipton K.F. –1989– Biochem. J. 261, 921.
Crasnier M., Moustacas A.M. & Ricard J. –1985– Eur. J. Biochem. 151, 187.
Engasser J.M. & Horváth C. –1976– Applied Biochem. Bioengng. 1, 127.
Fell D.A. –1992– Biochem. J. 286, 313.
Fell D.A. & Sauro H.M. –1985– Eur. J. Biochem. 148, 555.
Franck U.F. –1978– Angewandte Chemie 17, 8.
Gerisch G., Maeda Y., Malchow D., Roos W., Wick U. & Wurster B. –1977– Cyclic signals and the control of cell aggregation in Dictyostelium discoideum, in Developments and differentiation in the cellular slime moulds, Capuccinelli & Ashworth eds, Elsevier North Holland Biomedical Press, New York.
Goodsell D.S. –1991– TIBS 16, 203.
Heinrich R. & Rapoport T.A. –1974– Eur. J. Biochem. 42, 89.
Heinrich R., Rapoport S.M. & Rappoport T.A. –1977– Prog. Biophys. Biol. 32, 1.
Hervé G. –1996– Structural and functional dynamics of the cell, in Concepts in Biotechnology, K. Jayaraman, D. Balasubramanian & K. Dharmalingam eds, Madras University-UNESCO, 21–37.
Jenkins J.D., Kezdy F.J. & Steck T.L. –1985– J. Biol. Chem. 260, 10426.
Kacser H.–1987 J.Theoret.Biol. 126, 505.
Kacser H. & Burns J.A. –1979– Biochem. Soc. Trans. 7, 1149.
Mirande M., Lazard M., Kerjean P., Bec G., Agou F., Quevillon S. & Waller J.P. –1993– in The translational Apparatus, Nierhaus et al. eds, Plenum Press, New York, 657–668.
Newton A.C. –1995– J. Biol. Chem. 270, 28495.
Nicolis G. & Prigogine I. –1979– Proc. Natl. Acad. Sci. USA 76, 6060.
Noat G., Crasnier M. & Ricard J. –1980– Plant Cell Environ. 3, 225.
Ricard J. –1989– Catal. Today 5, 275.
Ricard J., Noat G., Crasnier M. & Job D. –1981– Biochem. J. 195, 357.
Ricard J., Mulliert G., Kellershohn N. & Giudici-Orticoni M.T. –1994– Dynamics of enzyme reactions and metabolic networks in living cells. A physico-chemical approach, in Progress in Molecular and Submolecular Biology, W.E.G. Müller ed.
Shulman R.G., Bloch G. & Rothman D.L. –1995– Proc. Natl Acad. Sci. USA 92, 8535.
Siderowicz A., Modrzycka T., Golebiowska J. & Siemieniewski H. –1990– FEBS Lett. 226, 175.
Thomas D., Bourdillon C., Broun G. & Kernevez J.P. –1974– Eur. J. Biochem. 13, 2995.
Vertessy B.G., Kovacs J. & Ovadi J. –1996– FEBS Lett. 379, 191.
Wang J., Morris, Tolan & Pagliaro L. –1996– J. Biol. Chem. 271, 6861
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Yon-Kahn, J., Hervé, G. (2009). Metabolic Control Theory. In: Molecular and Cellular Enzymology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01228-0_19
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DOI: https://doi.org/10.1007/978-3-642-01228-0_19
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