Abstract
As was shown in the preceding chapter, there is a great variety of enzymes cata-lysing very diverse chemical reactions. Some enzymes among the best known on the structural and functional level have been chosen in the present chapter to illustrate each of the reaction types. Enzymatic systems for which the three-dimensional structures are known both for the free enzyme and for the enzyme complexed to a substrate or to an analog are preferentially presented. Indeed, a precise knowledge of the position of substrate atoms with respect to enzyme catalytic groups is necessary for understanding reaction mechanisms; otherwise the amount of speculation remains too significant. However, even for particularly well described systems, the transition state and its interactions with the enzyme often remain hypothetical.
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Yon-Kahn, J., Hervé, G. (2009). Examples of Structure-Function Relationships in Enzymatic Systems. In: Molecular and Cellular Enzymology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01228-0_13
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