Chapter

Autophagy in Infection and Immunity

Volume 335 of the series Current Topics in Microbiology and Immunology pp 123-140

Date:

Autophagy in MHC Class II Presentation of Endogenous Antigens

  • Monique GannagéAffiliated withViral Immunobiology, Institute of Experimental Immunology, University Hospital of Zürich
  • , Christian MünzAffiliated withViral Immunobiology, Institute of Experimental Immunology, University Hospital of Zürich Email author 

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Abstract

Macroautophagy is a catabolic process for the lysosomal turnover of cell organelles and protein aggregates. Lysosomal degradation products are displayed by major histocompatibility class II molecules to CD4+ T cells in the steady state for tolerance induction and during infections to mount adaptive immune responses. It has recently been shown that macroautophagy substrates can also give rise to MHC class II ligands. We review here the breadth of antigens that may utilize this pathway and the possible implications of this alternate route to MHC class II antigen presentation for immunity and tolerance. Based on this discussion, it is apparent that the regulation of macroautophagy may be beneficial in various disease settings in order to enhance adaptive immune responses or to reduce autoimmunity.