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Prognostic Factors in Nasopharyngeal Cancer

  • Chapter
Nasopharyngeal Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

The prognosis of a cancer depends on the biological aggressiveness of the tumor, the characteristic of the host, and the therapeutic interventions. Prognostic factors of nasopharyngeal carcinoma (NPC) have been one of the most important research foci, and a large number of investigations in this area have been performed and published. The extent of local invasion, regional lymphatic spread, and distant metastasis, as reflected by the TNM staging, are the most important prognostic factors in NPC. Generally, advanced T-classification is associated with worse local control and overall survival; advanced N-classification predicts increased risk of both distant failure and suboptimal survival; and patients with distant metastasis, that is, M1 disease usually are not curable and have limited life expectancy. In addition, advances in imaging modalities, such as computerized tomography (CT) scan, magnetic resonance imaging (MRI), and positron emission tomography (PET) scan, make it possible to measure tumor volume and extension more precisely. A number of radiological criteria other than those required by the TNM staging have been reported to affect treatment outcome significantly. Furthermore, NPC has been proven as an EBV-associated disease. Recently, cell-free circulating EBV DNA has been detected in plasma and serum of NPC patients, and has been shown as a reliable prognosticator.

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Authors and Affiliations

  1. Department of Radiation Oncology, Taichung Veterans General Hospital, No. 160, Sec. 3, Taichung-Kang Road, Taichung City, Taiwan, 407, ROC

    Jin-Ching Lin

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  1. Jin-Ching Lin
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Editors and Affiliations

  1. Department of Radiation Oncology, National University Cancer Institute of Singapore National University Health System National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Republic of Singapore

    J. J. Lu (Associate Professor and Consultant, Distinguished Clinical Professor) (Associate Professor and Consultant, Distinguished Clinical Professor)

  2. Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200232, P.R. China

    J. J. Lu (Associate Professor and Consultant, Distinguished Clinical Professor) (Associate Professor and Consultant, Distinguished Clinical Professor)

  3. Department of Radiation Oncology, Maimonides Cancer Center, 6300 Eighth Avenue, Brooklyn, NY, 11220, USA

    J. S. Cooper (Professor and Chairman) (Professor and Chairman)

  4. Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong SAR, P.R. China

    A. W. M. Lee

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Lin, JC. (2010). Prognostic Factors in Nasopharyngeal Cancer. In: Lu, J.J., Cooper, J.S., Lee, A.W.M. (eds) Nasopharyngeal Cancer. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92810-2_9

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  • DOI: https://doi.org/10.1007/978-3-540-92810-2_9

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