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Mitochondrial Genetics and Sepsis

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Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2009))

Abstract

Mitochondria are intracellular organelles that generate the principal source of cellular energy in the form of adenosine triphosphate (ATP). In a highly efficient process, mitochondria convert both carbohydrate and fat into high-energy phosphate compounds by a series of intermediate steps involving electron transfer. Emerging data implicate mitochondrial damage and dysfunction as critical factors in the pathogenesis of sepsis.

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Author information

Authors and Affiliations

  1. Mitochondrial Research Group Institute of Ageing and Health, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK

    A. Pyle & P. Chinnery

  2. Department of Anesthesia, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE2 4HH, UK

    S. Baudouin

Authors
  1. A. Pyle
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  2. P. Chinnery
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  3. S. Baudouin
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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© 2009 Springer-Verlag Berlin Heidelberg

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Pyle, A., Chinnery, P., Baudouin, S. (2009). Mitochondrial Genetics and Sepsis. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2009. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92276-6_2

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  • DOI: https://doi.org/10.1007/978-3-540-92276-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-92275-9

  • Online ISBN: 978-3-540-92276-6

  • eBook Packages: MedicineMedicine (R0)

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