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Inflammatory Skin Conditions During Pregnancy

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Atopic dermatitis is an inflammatory itching skin disease, with increasing prevalence worldwide during the last few decades, especially in industrialized countries [43]. One study showed that the cumulative incidence in children born before 1960 was 2–3%, rose to 4–8% during the 1960s, in the 1970s rose to 9–12%, and in the 1980s rose to 15–20% [57] Atopic dermatitis has a variable course with regard to age, morphology, and distribution [42], and it is more frequently reported by women than by men, with the highest rate (25.3%) seen in the age range of 20–29 years [43].

Atopic dermatitis is considered to be a multifactorial disease influenced by genetic predisposition and environmental factors. The process of this inflammatory condition was suggested to be dependent on the production of cytokines by allergen-specific Th2 cells [35]. This theory was recently further strengthened by showing that transgenic mice expressing high levels of Th2 cytokines developed diffuse spontaneous atopic dermatitis and expressed high levels of serum IgE [35]. Pregnancy, as described earlier, is also suggested to be a Th2 condition [70]. Thus, it would be expected that atopic dermatitis would flare during pregnancy [62].

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(2009). Inflammatory Skin Conditions During Pregnancy. In: Obstetric Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88399-9_7

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  • DOI: https://doi.org/10.1007/978-3-540-88399-9_7

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