Abstract
Septic shock is accompanied by profound cardiovascular alterations, including a decrease in vascular tone, hypovolemia, and myocardial depression. Hence, the hemodynamic treatment represents a true challenge for intensivists because all of these mechanisms of shock can be associated, and at any given moment the dominant mechanism may be different. Making the correct diagnosis thus becomes somewhat complicated, especially with adapted treatment. By its ability to assess the problem in a step-by-step fashion and independently of the different variables of cardiovascular function, echocardiography is particularly adapted to the situation.
The role of echocardiography in septic shock is to evaluate fluid responsiveness and document whether left and/or right ventricular dysfunction are present and are contributing to circulatory failure. Indeed, it is quite common that left, but also right, ventricular dysfunction are observed, but these often do not compromise the hemodynamic response to sepsis. It one-third of patients in septic shock, cardiac dysfunction becomes a limiting factor. To differentiate between asymptomatic and symptomatic myocardial dysfunction, it is useful to measure cardiac output and evaluate its adequacy to oxygen demand.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Michard F, Teboul JL (2002) Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence. Chest 121:2000–2008
Wiedemann HP, Wheeler AP, Bernard GR et al (2006) Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 354:2564–2575
Sakr Y, Reinhart K, Vincent JL et al (2006) Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med 34:589–597
Charron C, Caille V, Jardin F et al (2006) Echocardiographic measurement of fluid responsiveness. Curr Opin Crit Care 12:249–254
MacLean LD, Mulligan WG, McLean APH et al (1967) Patterns of septic shock in man – a detailed study of 56 patients. Ann Surg 166:543–559
Parker MM, Shelhamer JH, Bacharach SL et al (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483–490
Suffredini AF, Fromm RE, Parker MM et al (1989) The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321:280–287
Ozier Y, Gueret P, Jardin F et al (1984) Two-dimensional echocardiographic demonstration of acute myocardial depression in septic shock. Crit Care Med 12:596–599
Jardin F, Brun-Ney D, Auvert B et al (1990) Sepsis-related cardiogenic shock. Crit Care Med 18:1055–1060
Parker MM, McCarthy KE, Ognibene FP et al (1990) Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans. Chest 97:126–131
Dhainaut JF, Pinsky MR, Nouria S et al (1997) Right ventricular function in human sepsis: a thermodilution study. Chest 112:1043–1049
Parillo JE, Burch C, Shelhamer JH (1985) A circulating myocardial depressant substance in humans with septic shock. J Clin Invest 76:1539–1553
Natanson C, Eichenholz PW, Danner RL et al (1989) Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 169:823–832
Hollenberg SM, Cunnion RE, Lawrence M et al (1989) Tumor necrosis factor depress myocardial cell function: results using an in vitro assay of myocyte performance. Clin Res 37:528–534
Cunnion RE, Schaer GL, Parker MM et al (1986) The coronary circulation in human septic shock. Circulation 73:637–644
Dhainaut JF, Huyghebaert MF, Monsallier JF et al (1987) Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 75:533–541
Ince C, Ashruf JF, Avontuur JA et al (1993) Heterogeneity of the hypoxic state in rat heart is determined at capillary level. Am J Physiol 264:H294–H301
Levy RJ, Piel DA, Acton PD et al (2005) Evidence of myocardial hibernation in the septic heart. Crit Care Med 33:2752–2756
Tavernier B, Mebazaa A, Mateo P et al (2001) Phosphorylation-dependent alteration in myofilament ca2+ sensitivity but normal mitochondrial function in septic heart. Am J Respir Crit Care Med 163:362–367
Tavernier B, Li JM, El Omar MM et al (2001) Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats. FASEB J 15:294–296
Vieillard-Baron A, Caille V, Charron C et al (2008) Actual incidence of global left ventricular hypokinesia in adult septic shock. Crit Care Med 36:1701–1706
Natanson C, Danner RL, Fink MP et al (1988) Cardiovascular performance with E. coli challenges in a canine model of human sepsis. Am J Physiol 254:H558–H569
Parker MM, Shelhamer JH, Natanson C (1987) Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit Care Med 15:923–929
Kumar A, Schupp E, Bunnell E et al (2008) Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock. Crit Care 12:R35
Vincent J-L, Roman A, Kahn RJ (1990) Dobutamine administration in septic shock: addition to a standard protocol. Crit Care Med 18:689–693
Morelli A, De Castro S, Teboul JL et al (2005) Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 31:638–644
Rivers E, Nguyen B, Havstadt S et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377
Loubieres Y, Vieillard-Baron A, Beauchet A et al (2000) Echocardiographic evaluation of left ventricular function in critically ill patients: dynamic loading challenge using medical antishock trousers. Chest 118:1718–1723
Bouhemad B, Nicolas-Robin A, Arbelot C et al (2008) Isolated and reversible impairment of ventricular relaxation in patients with septic shock. Crit Care Med 36:766–774
Zanotti-Cavazzoni SL, Guglielmi M, Parrillo JE et al (2009) Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis. Intensive Care Med 35:748–754, Epub 2008 Dec 9
Etchecopar-Chevreuil C, Francois B, Clavel M et al (2008) Cardiac morphological and functional changes during early septic shock: a transesophageal echocardiographic study. Intensive Care Med 34:250–256
Vieillard-Baron A, Schmitt JM, Beauchet A et al (2001) Early preload adaptation in septic shock? A transesophageal echocardiographic study. Anesthesiology 94:400–406
Jardin F, Fourme T, Page B et al (1999) Persistent preload defect in severe sepsis despite fluid loading: a longitudinal echocardiographic study in patients with septic shock. Chest 116:1354–1359
Schneider AJ, Teule GJ, Groeneveld AB et al (1988) Biventricular performance during volume loading in patients with early septic shock, with emphasis on the right ventricle: a combined hemodynamic and radionuclide study. Am Heart J 116:103–112
Osman D, Monnet X, Castelain V et al (2009) Incidence and prognostic value of right ventricular failure in acute respiratory distress syndrome. Intensive Care Med 35:69–76
Vieillard-Baron A, Prin S, Chergui K et al (2003) Hemodynamic instability in sepsis: bedside assessment by Doppler echocardiography. Am J Respir Crit Care Med 168:1270–1276
Cholley BP, Lang RM, Berger DS et al (1995) Alterations in systemic arterial mechanical properties during septic shock: role of fluid resuscitation. Am J Physiol 269:H375–H384
De Backer D, Zhang H, Cherkhaoui S et al (2001) Effects of dobutamine on hepato-splanchnic hemodynamics in an experimental model of hyperdynamic endotoxic shock. Shock 15:208–214
Axler O, Tousignant C, Thompson CR et al (1997) Small hemodynamic effect of typical rapid volume infusions in critically ill patients. Crit Care Med 25:965–970
Vignon P, AitHssain A, Francois B et al (2008) Echocardiographic assessment of pulmonary artery occlusion pressure in ventilated patients: a transoesophageal study. Crit Care 12:R18
Combes A, Arnoult F, Trouillet JL (2004) Tissue Doppler imaging estimation of pulmonary artery occlusion pressure in ICU patients. Intensive Care Med 30:75–81
Jardin F, Valtier B, Beauchet A et al (1994) Invasive monitoring combined with two-dimensional echocardiographic study in septic shock. Intensive Care Med 20:550–554
Vieillard-Baron A, Charron C, Chergui K et al (2006) Bedside echocardiographic evaluation of hemodynamics in sepsis: is a qualitative evaluation sufficient? Intensive Care Med 32:1547–1552
Vincent JL, Roman A, Kahn RJ (1990) Dobutamine administration in septic shock: addition to a standard protocol. Crit Care Med 18:689–693
Leone M, Boyadjiev I, Boulos E et al (2006) A reappraisal of isoproterenol in goal-directed therapy of septic shock. Shock 26:353–357
Jellema WT, Groeneveld AB, Wesseling KH et al (2006) Heterogeneity and prediction of hemodynamic responses to dobutamine in patients with septic shock. Crit Care Med 34:2392–2398
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Berlin Heidelberg
About this chapter
Cite this chapter
De Backer, D., Vieillard-Baron, A. (2011). Septic Shock. In: de Backer, D., Cholley, B., Slama, M., Vieillard-Baron, A., Vignon, P. (eds) Hemodynamic Monitoring Using Echocardiography in the Critically Ill. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87956-5_11
Download citation
DOI: https://doi.org/10.1007/978-3-540-87956-5_11
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-87954-1
Online ISBN: 978-3-540-87956-5
eBook Packages: MedicineMedicine (R0)