Skip to main content

Metabolic Mapping

  • Chapter
Medical Retina

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Schweitzer D, Leistritz L, Hammer M et al (1995) Calibration-free measurement of the oxygen saturation in retinal vessels of men. Ophthalmic Technol V, SPIE 2393: 210–218

    Article  Google Scholar 

  2. Feke GT (2006) Laser Doppler instrumentation for the measurement of retinal blood flow: theory and practice. Bull Soc Belge Ophtalmol 302:171–184

    PubMed  Google Scholar 

  3. Leitgeb RA, Schmetterer L, Hitzenberger CK et al (2004) Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography. Opt Lett 29(2):171–173

    Article  PubMed  Google Scholar 

  4. Beach JM, Schwenzer KJ, Srinivas S et al (1999) Oximetry of retinal vessels by dual-wavelength imaging: calibration and influence of pigmentation. J Appl Physiol 86(2): 748–758

    PubMed  CAS  Google Scholar 

  5. Schweitzer D, Hammer M, Kraft J et al (1999) In vivo measurement of the oxygen saturation of retinal vessels in healthy volunteers. IEEE Trans Biomed Eng 46 (12): 1454–1465

    Article  PubMed  CAS  Google Scholar 

  6. Schweitzer D, Lasch A, van der Vorst S et al (2007) Änderung der retinalen Sauerstoffsättigung bei Gesunden und in frühen Stadien der diabetische Retinopathie nach Atmung von 100% Sauerstoff. Klin Monatsbl Augenheilkd 224:402–410

    Article  PubMed  CAS  Google Scholar 

  7. Stryer L (1991) Biochemie. Spectrum Akademischer, Verlag GmbH Heidelberg

    Google Scholar 

  8. Boettner EA, Wolter JR (1962) Transmission of the ocular media. Invest Ophthalmol 1:776–783

    Google Scholar 

  9. La Schiazza O, Bille JF (2008) High-speed two-photon excited autofluorescence imaging of ex vivo human retinal pigment epithelial cells toward age-related macular degeneration diagnostic. J Biomed Opt 13(6):064008

    Article  PubMed  Google Scholar 

  10. American National Standard for the safe use of laser ANSI Z 136.1–2000 (2000) Laser Institute of America, Orlando, FL

    Google Scholar 

  11. Schweitzer D, Schenke S, Hammer M et al (2007) Towards metabolic mapping of the human retina. Microsc Res Tech 70:410–419

    Article  PubMed  CAS  Google Scholar 

  12. Sionkowska A, Skopinska J, Wisniewski M et al (2007) Spectroscopic studies into the influence of UV radiation on elastin in the presence of collagen. J Photochem Photobiol B Biol 86:186–191

    Article  CAS  Google Scholar 

  13. Skala MC, Riching KM, Gendron-Fitzpatrick A et al (2007) In vivo multiphoton microscopy of metabolic oxidation-reduction states and fluorescence lifetimes in normal and pre-cancerous epithelia. Proc Natl Acad Sci U S A 104(49): 19494–19499

    Article  PubMed  CAS  Google Scholar 

  14. Yagi K, Tanaka F, Nakashima N et al (1983) Picosecond laser fluorometry of FAD of D-amino acid oxidase-benzoate complex. J Biol Chem 258(6):3799–3802

    PubMed  CAS  Google Scholar 

  15. Nakashima N, Yoshihara K, Tanaka F et al (1980) Picosecond fluorescence lifetime of the coenzyme of D-amino acid oxidase. J Biol Chem 255 (11):5261–5263

    PubMed  CAS  Google Scholar 

  16. König K, Riemann I (2003) High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution. J Biomed Opt 8 (3): 432–439

    Article  PubMed  Google Scholar 

  17. Schneckenburger H, Wagner M, Weber P et al (2004) Autofluorescence lifetime imaging of cultivated cells using a UV picosecond laser diode. J Fluoresc 14 (5): 649–654

    Article  PubMed  CAS  Google Scholar 

  18. Wu Y, Zheng W, Qu J (2006) Sensing cell metabolism by time-resolved autofluorescence. Opt Lett 31(21): 3122–3124

    Article  PubMed  CAS  Google Scholar 

  19. Schweitzer D, Jentsch S, Schenke S et al (2007) Spectral and time-resolved studies on ocular structures. In: Schweitzer D, Fitzmaurice M (eds) Diagnostic optical spectroscopy in biomedicine IV. Proceedings of the SPIE, 6628,pp 662807-1–662807-12

    Google Scholar 

  20. Schweitzer D, Kolb A, Hammer M et al (2000) Tau mapping of the autofluorescence of the human ocular fundus. SPIE 4164:79–89

    Article  Google Scholar 

  21. Goldenberg-Cohen N, Dadon S, Avraham BCR et al (2008) Molecular and histological changes following central retinal artery occlusion in a mouse model. Exp Eye Res 87: 327–333

    Article  PubMed  CAS  Google Scholar 

  22. Lakowicz JR (2007) Principles of fluorescence spectroscopy, 3rd edn. Kluwer, Academic, Plenum, New York

    Google Scholar 

  23. Becker W (2005) Advanced time-correlated single photon counting techniques. Springer Series in Chemical Physics 81. Springer, Berlin

    Book  Google Scholar 

  24. Schweitzer D, Hammer M, Schweitzer F et al (2004) In vivo measurement of time-resolved autofluorescence at the human fundus. J Biomed Opt 9(6)1214–1222

    Article  PubMed  Google Scholar 

  25. Schweitzer D, Quick S, Schenke S et al (2009) Vergleich von Parametern der zeitaufgelösten Autofluoreszenz bei Gesunden und Patienten mit früher AMD. Ophthalmologe 9(6):714–722

    Article  Google Scholar 

  26. AREDS Research Group (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No 8. Arch Ophthalmol 119(10):1417–1436

    Article  Google Scholar 

  27. Eldred GE, Katz ML (1988) Fluorophores of the human pigment epithelium: separation and spectral characterization. Exp Eye Res 47:71–86

    Article  PubMed  CAS  Google Scholar 

  28. Schweitzer D (2010) Quantifying fundus autofluorescence. In: Lois N, Forrester JV (eds) Fundus autofluorescence. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  29. Bindewald A, Bird AC, Dandekar SS et al (2005) Classification of fundus autofluorescence patterns in early age-related macular diseases. Invest Ophthalmol Vis Sci 46:3309–3314

    Article  PubMed  Google Scholar 

  30. Birol G, Budzynski E, Wangsa-Wirawan ND et al (2005) Retinal arterial occlusion leads to acidosis in the cat. Exp Eye Res 80:527–533

    Article  PubMed  CAS  Google Scholar 

  31. Wakita M, Nishimura G, Tamura M (1995) Some characteristics of the fluorescence lifetime of reduced pyridine nucleotides in isolated mitochondria, isolated hepatocytes, and perfused rat liver in situ. J Biochem 118:1151–1160

    PubMed  CAS  Google Scholar 

  32. Wang HW, Gukassyan V, Chen CT et al (2008) Differentiation of apoptosis from necrosis by dynamic changes of reduced nicotinamide adenine dinucleotide fluorescence lifetime in live cells. J Biomed Opt 13(5):054011

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dietrich Schweitzer .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schweitzer, D. (2010). Metabolic Mapping. In: Holz, F.G., Spaide, R. (eds) Medical Retina. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85540-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-85540-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85539-2

  • Online ISBN: 978-3-540-85540-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics