Skip to main content

History of Radiotherapy of Hodgkin’s Disease (Now Hodgkin Lymphoma)

  • Chapter
  • First Online:

Abstract

Radiotherapy for Hodgkin’s disease was carried out shortly after the discovery of X-rays with primitive equipment allowing only superficial treatment to small fields. Impressive responses gave rise to optimism which was quickly tempered by the almost inevitable recurrences. With better equipment and more extended treatment fields, cures were eventually obtained even during the kilovolt era. With the advent of megavolt equipment and very extensive treatment fields, cure became a reality for most patients with localized disease. However, with the advent of effective chemotherapy, the role of radiotherapy has changed. Modern advanced radiotherapy technology is now implemented to enable the use of limited radiotherapy in combination with chemotherapy to maximize the chance of cure while minimizing long-term complications.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Coley WB (1915) Primary neoplasms of the lymphatic glands including Hodgkin’s disease. In: Binnie JF (ed) Transactions of the American surgical association. William J. Dornan, Philadelphia

    Google Scholar 

  • Desjardins AU, Ford F (1923) Hodgkin’s disease and lymphosarcoma; clinical and statistical study. JAMA 81:925–927

    Article  Google Scholar 

  • Dubois JB, Ash D (1995) The discovery of X-rays and radioactivity. In: Bernier J (ed) Radiation oncology: a century of progress and achievement. The European Society for Therapeutic Radiology and Oncology, Brussels

    Google Scholar 

  • Easson EC (1966) Possibilities for the cure of Hodgkin’s disease. Cancer 19:345–350

    Article  Google Scholar 

  • Easson EC, Russell MH (1963) The cure of Hodgkin’s disease. BMJ 1963:1704–1707

    Article  Google Scholar 

  • Gilbert R (1925) La roentgenthérapie de la granulomatose maligne. J Radiol Electrol 9:509–514

    Google Scholar 

  • Gilbert R, Babaïantz L (1931) Notre méthode de roentgenthérapie de la lymphogranulomatose (Hodgkin): résultats éloignés. Acta Radiol 12:523–529

    Article  Google Scholar 

  • Girinsky T, van der Maazen R, Specht L et al (2006) Involved-node radiotherapy (INRT) in patients with early Hodgkin lymphoma: concepts and guidelines. Radiother Oncol 79:270–277

    Article  PubMed  Google Scholar 

  • Henry-Amar M (1983) Second cancers after radiotherapy and chemotherapy for early stages of Hodgkin’s disease. J Natl Cancer Inst 71:911–916

    PubMed  CAS  Google Scholar 

  • Hoppe RT (1997) Hodgkin’s disease: complications of therapy and excess mortality. Ann Oncol 8(Suppl 1):115–118

    Article  PubMed  Google Scholar 

  • Hoppe RT, Horning SJ, Rosenberg SA (1985) The concept, evolution and preliminary results of the current Stanford clinical trials for Hodgkin’s disease. Cancer Surv 4:459–475

    PubMed  CAS  Google Scholar 

  • Kaplan HS (1962) The radical radiotherapy of regionally localized Hodgkin’s disease. Radiology 78:553–561

    PubMed  CAS  Google Scholar 

  • Kaplan HS (1966) Long-term results of palliative and radical radiotherapy of Hodgkin’s disease. Cancer Res 26:1250–1252

    PubMed  CAS  Google Scholar 

  • Lederman M (1981) The early history of radiotherapy: 1895-1939. Int J Radiat Oncol Biol Phys 7:639–648

    Article  PubMed  CAS  Google Scholar 

  • Minot GR (1926) Lymphoblastoma. Radiology 7:119–120

    Google Scholar 

  • Peters MV (1950) A study of survivals in Hodgkin’s disease treated radiologically. Am J Roentgenol 63:299–311

    Google Scholar 

  • Peters MV, Middlemiss KCH (1958) A study of Hodgkin’s disease treated by irradiation. Am J Roentgenol 79:114–121

    CAS  Google Scholar 

  • Pusey WA (1902) Cases of sarcoma and of Hodgkin’s disease treated by exposures to X-rays - a preliminary report. JAMA 38:166–169

    Article  Google Scholar 

  • Röntgen WC (1895) Über eine neue Art von Strahlen. Sitzungsberichte der physikalisch-medicinischen Gesellschaft zu Würzburg Sitzung 30:132–141

    Google Scholar 

  • Rosenberg SA, Kaplan HS (1970) Hodgkin’s disease and other malignant lymphomas. Calif Med 113:23–38

    PubMed  CAS  Google Scholar 

  • Senn N (1903) The therapeutical value of the Röntgen ray in the treatment of pseudoleucæmia. NY Med J 77:665–668

    Google Scholar 

  • Specht L, Gray RG, Clarke MJ et al (1998) Influence of more extensive radiotherapy and adjuvant chemotherapy on long-term outcome of early-stage Hodgkin’s disease: a meta-analysis of 23 randomized trials involving 3, 888 patients. International Hodgkin’s Disease Collaborative Group. J Clin Oncol 16:830–843

    PubMed  CAS  Google Scholar 

  • Travis LB, Curtis RE, Boice JD (1996) Late effects of treatment for childhood Hodgkin’s disease. N Engl J Med 335:352–353

    Article  PubMed  CAS  Google Scholar 

  • Tubiana M, Henry-Amar M, Hayat M et al (1979) Long-term results of the E.O.R.T.C. randomized study of irradiation and vinblastine in clinical stages I and II of Hodgkin’s disease. Eur J Cancer 15:645–657

    PubMed  CAS  Google Scholar 

  • van Leeuwen FE, Klokman WJ, Hagenbeek A et al (1994) Second cancer risk following Hodgkin’s disease: a 20-year follow-up study. J Clin Oncol 12:312–325

    PubMed  Google Scholar 

  • Yahalom J, Mauch P (2002) The involved field is back: issues in delineating the radiation field in Hodgkin’s disease. Ann Oncol 13(Suppl 1):79–83

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lena Specht .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Specht, L., Rosenberg, S. (2011). History of Radiotherapy of Hodgkin’s Disease (Now Hodgkin Lymphoma). In: Specht, L., Yahalom, J. (eds) Radiotherapy for Hodgkin Lymphoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78944-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-78944-4_1

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78455-5

  • Online ISBN: 978-3-540-78944-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics