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MicroRNAs and the Control of Heart Pathophysiology

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RNA Technologies in Cardiovascular Medicine and Research

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Abstract

MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that control gene expression at a posttranscriptional level. They are one of the most abundant class of gene regulatory molecules in multicellular organisms, and are being implicated in an increasing number of biological processes. Many miRNAs are expressed in a tissue-specific manner during development and take part in the regulation of cell-lineage decisions and morphogenesis. Moreover, much work is now highlighting their importance for malformations and disease. This chapter presents knowledge on miRNA biology, and then describes the recent findings regarding aspects of cardiovascular pathophysiology.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, BSB 5022, LaJolla, San Diego, Ca, 92093-0613, USA

    D. Catalucci & G. Condorelli

  2. Scientific and Technology Pole, IRCCS MultiMedica, Via G. Fantoli 16/15, 20138, Milan, Italy

    D. Catalucci, M. V. G. Latronico & G. Condorelli

Authors
  1. D. Catalucci
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  2. M. V. G. Latronico
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  3. G. Condorelli
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Corresponding author

Correspondence to D. Catalucci .

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Editors and Affiliations

  1. Institute for Chemistry/Biochemistry, Free University of Berlin, Thielallee 63, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Clinic for Cardiology and Pneumology Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Wolfgang Poller

  3. Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Noskowskiego 12, 61-704, Poznan, Poland

    Jan Barciszewski

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Catalucci, D., Latronico, M.V.G., Condorelli, G. (2008). MicroRNAs and the Control of Heart Pathophysiology. In: Erdmann, V.A., Poller, W., Barciszewski, J. (eds) RNA Technologies in Cardiovascular Medicine and Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78709-9_4

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