Skip to main content
SpringerLink
Log in

Combined MPM/OCT System and Second Harmonic OCT

  • Chapter
Optical Coherence Tomography

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

  • 10k Accesses

Although medicine has evolved rapidly with advances in biotechnology, many therapeutic procedures still require diagnosis of disease at an early stage to enable effective treatment and prevent irreversible damage. Direct visualization of cross-sectional tissue anatomy and physiology provides important information for the diagnosis, staging, and management of disease. Optical coherence tomography (OCT) is a promising noninvasive, noncontact imaging modality that uses coherence gating to obtain cross-sectional images of tissue microstructure with micrometer spatial resolution [1]. OCT was first used clinically in ophthalmology for the imaging and diagnosis of retinal disease [2]. Recently, it has been applied to image subsurface structure in skin, vessels, oral cavities, as well as respiratory, urogenital, and gastrointestinal tracts.

In this chapter, we describe a combined MPM/OCT system that allows studies of OCT scattering contrast with the sub-cellular resolution [7–12]. In addition, we present an SH-OCT system that combines the nonlinear optical effect of SHG and coherence gating of OCT to produce highly contrasting cross-sectional images of biological tissues [13–18].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, J.G. Fujimoto, Science 254, 1178 (1991).

    Article  CAS  PubMed  Google Scholar 

  2. M.R. Lee, J.A. Izatt, E.A. Swanson, D. Huang, J.S. Schumun, C.P. Lin, C.A. Puliafito, J.G. Fujimoto, IEEE Eng. Med. Biol. Mag. 14, 67 (1995).

    Article  Google Scholar 

  3. W. Denk, J.H. Strickler, W.W. Webb, Science 248, 73 (1990).

    Article  CAS  PubMed  Google Scholar 

  4. W.R. Zipfel, R.M. Williams, W.W. Webb, Nat. Biotechnol. 21, 1369 (2003).

    Article  CAS  PubMed  Google Scholar 

  5. W.R. Zipfel, R.M. Williams, R.A. Christie, Y. Nikitin, B.T. Hyman, Proc. Nat. Acad. Sci. USA 100, 7075 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. C.K. Sun, C.C. Chen, S.W. Chu, T.H. Tsai, Y.C. Chen, B.L. Lin, Opt. Lett. 28,2488 (2003).

    Article  PubMed  Google Scholar 

  7. E. Beaurepaire, L. Moreaux, F. Amblard, J. Mertz, Opt. Lett. 24, 969 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. S. Tang, T.B. Krasieva, Z. Chen, B. Tromberg, J. Biomed. Opt. 11, 020502 (2006)

    Google Scholar 

  9. S. Tang, C.H. Sun, T.B. Krasieva, Z. Chen, B. Tromberg, Opt. Lett. 32, 503 (2007).

    Article  PubMed  Google Scholar 

  10. C. Vinegoni, T.S. Ralston, W. Tan, W. Luo, D.L. Marks, S.A. Boppart, Appl. Phys. Lett. 88, 053901 (2006).

    Google Scholar 

  11. C. Joo, K.H. Kim, J.F. de Boer, Opt. Lett. 32, 623 (2007).

    Article  PubMed  Google Scholar 

  12. S. Yazdanfar, Y.Y. Chen, P.T.C. So, L.H. Laiho, Microsc. Res. Tech. 70, 503 (2007).

    Article  Google Scholar 

  13. Y. Jiang, I. Tomov, Y. Wang, Z. Chen, Opt. Lett. 29, 1090 (2004).

    Article  PubMed  Google Scholar 

  14. Y. Jiang, I. Tomov, Y. Wang, Z. Chen, Appl. Phys. Lett. 86, 133901 (2005).

    Google Scholar 

  15. S. Yazdanfar, L.H. Laiho, P.T.C. So, Opt. Express 12, 2739 (2004).

    Article  PubMed  Google Scholar 

  16. B.E. Applegate, C. Yang, A.M. Rollins, J.A. Izatt, Opt. Lett. 29, 2252 (2004).

    Article  PubMed  Google Scholar 

  17. M.V. Sarunic, B.E. Applegate, J.A. Izatt, Opt. Lett. 30, 2391 (2005).

    Article  PubMed  Google Scholar 

  18. J. Su, I.V. Tomov, Y. Jiang, Z. Chen, Appl. Opt. 46, 1770 (2007).

    Article  PubMed  Google Scholar 

  19. J.P. Dunkers, M.T. Cicerone, N.R. Washburn, Opt. Express 11, 3074 (2003).

    CAS  PubMed  Google Scholar 

  20. G.M. Dobre, A.G. Podoleanu, R.B. Rosen, Opt. Lett. 30, 58 (2005).

    Article  CAS  PubMed  Google Scholar 

  21. C. Xu, W.R. Zipfel, J.B. Shear, R.M. Williams, W.W. Webb, Proc. Natl. Acad. Sci. USA 93, 10763 (1996).

    Article  CAS  PubMed  Google Scholar 

  22. K. Konig, J. Microsc. 200, 83 (2000).

    Article  CAS  PubMed  Google Scholar 

  23. A. Zoumi, A. Yeh, B.J. Tromberg, Proc. Nat. Acad. Sci. 99, 11014 (2002).

    Article  CAS  PubMed  Google Scholar 

  24. P.J. Campagnola, M.D. Wei, A. Lewis, L.M. Loew, Biophys. J. 77, 3341 (1999).

    Article  CAS  PubMed  Google Scholar 

  25. A.T. Yeh, S. Kao, W.G. Jung, Z. Chen, J.S. Nelson, B. Tromberg, J. Biomed. Opt. 9, 248 (2004).

    Article  PubMed  Google Scholar 

  26. P. Wilder-Smith, T. Krasieva, W.G. Jung, J. Zhang, Z. Chen, K. Osann, B. Tromberg, J. Biomed. Opt. 10, 051601 (2005).

    Google Scholar 

  27. P.J. Campagnola, L.M. Loew, Nat. Biotechnol. 21, 1356 (2003).

    Article  CAS  PubMed  Google Scholar 

  28. Y.R. Shen, The Principles of Nonlinear Optics (Wiley, New York, 1984).

    Google Scholar 

  29. A.F. Fercher, W. Drexler, C.K. Hizenberger, Rep. Prog. Phys. 66, 239 (2003).

    Article  Google Scholar 

  30. M. Müller, J. Squier, G.J. Brakenhoff, Opt. Lett. 20, 1038 (1995).

    Article  PubMed  Google Scholar 

  31. M. Müller, J. Squier, R. Wolleschensky, U. Simon, G.J. Brakenhoff, J. Microsc. 191,141-50 (1998).

    Article  PubMed  Google Scholar 

  32. B. Beauvoit, T. Kitai, B. Chance, Biophys. J. 67, 2501 (1994).

    Article  CAS  PubMed  Google Scholar 

  33. I. Freund, M. Deutsch, Opt. Lett. 11, 94 (1986).

    Article  CAS  PubMed  Google Scholar 

  34. J. Mertz, L. Moreausx, Opt. Commun. 196, 325 (2001).

    Article  CAS  Google Scholar 

  35. L. Moreaux, O. Sandre, L. Mertz, J. Opt. Soc. Am. B 17, 1685 (2000).

    Article  CAS  Google Scholar 

  36. P.J.A. Campagnola, C. Millard, M. Terasaki, P.E. Hoppe, J.C. Malone, W.A. Mohler, Biophys. J. 82, 493 (2002).

    Article  CAS  PubMed  Google Scholar 

  37. D.A. Dombeck, K.A. Kasischke, H.D. Vishwasrao, M. Ingelsson, B.T. Hyman, and W.W. Webb, Proc. Nat. Acad. Sci. USA 100, 7081 (2003).

    Article  CAS  PubMed  Google Scholar 

  38. G. Cox, E. Kable, A. Jones, I.K. Fraser, F. Manconi, M.D. Gorrell, J. Struct. Biol. 141, 53 (2003).

    Article  CAS  PubMed  Google Scholar 

  39. H.K. Aghajan, B.H. Khalaj, T. Kailath, Image and Video Processing II, San Jose, CA, USA, vol. 2182, pp. 78-89 (1994).

    Google Scholar 

  40. Y.C. Guo, H.E. Savage, F. Liu, S.P. Schantz, P.P. Ho, R.R. Alfano, Proc. Nat. Acad. Sci. USA 96, 10854 (1999).

    Article  CAS  PubMed  Google Scholar 

  41. E. Brown, T. McKee, E. diTomaso, A. Pluen, B. Seed, Y. Boucher, R.K. Jain, Nat. Med. 9, 796 (2003).

    Article  CAS  PubMed  Google Scholar 

  42. P. Wilder-Smith, K. Osann, N. Hanna, N. El Abbadi, M. Brenner, D.D.V. Messadi, T. Krasieva, Lasers Surg. Med. 35, 96 (2004).

    Article  PubMed  Google Scholar 

  43. D.A. Dombeck, M. Blanchard-Desce, W.W. Webb, J. Neurosci. 24, 999 (2004)

    Article  CAS  PubMed  Google Scholar 

  44. R. Leitgeb, C.K. Hitzenberger, A.F. Fercher, M. Kulhavy, Opt. Express 11, 889 (2003).

    Article  CAS  PubMed  Google Scholar 

  45. K. Konig, T.W. Becker, P. Fisher, I. Riemann, K.J. Halbhuber, Opt. Lett. 24, 113 (1999).

    Article  CAS  PubMed  Google Scholar 

  46. B.M. Kim, J. Eichler, K.M. Reiser, A.M. Rubenchik, L.B. Dasilva, Lasers Surg. Med. 27, 329 (2000).

    Article  CAS  PubMed  Google Scholar 

Download references

Authors
  1. Z. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4LU, UK

    Wolfgang Drexler

  2. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139-4307, USA

    James G. Fujimoto

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Chen, Z., Tang, S. (2008). Combined MPM/OCT System and Second Harmonic OCT. In: Drexler, W., Fujimoto, J.G. (eds) Optical Coherence Tomography. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77550-8_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-77550-8_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77549-2

  • Online ISBN: 978-3-540-77550-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation