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Late Toxicity from Hypofractionated Stereotactic Body Radiation

  • Chapter
Cured II ■ LENT Cancer Survivorship Research and Education

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Stereotactic body radiation therapy (SBRT) utilizes a three dimensional coordinate system to achieve more reproducible patient set-up [1, 2]. With SBRT, the margins for set-up uncertainty can be reduced, allowing greater volume sparing of the surrounding normal tissues. Since SBRT yields a reduced volume of normal tissue exposure, SBRT has been used to increase the fractional dose of radiation (hypofractionation) in an attempt to intensify the dose delivery without incrementally increasing the risk of normal tissue damage. This is becoming an important approach to treating discrete tumors, and has yielded impressive local control of treated tumors without significant toxicity. The benefit of SBRT is to achieve improved local control compared to conventional radiation, via improved target localization and more intense doles delivery, without the added toxicity. Arguably, SBRT can achieve similar or even improved outcome over surgical resection. One advantage that SBRT has over a limited resection (i.e. one that does not achieve wide margins) is that the penumbra dose around the target treats microscopic disease [3].

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY, 4642, USA

    Michael T. Milano MD, PhD, Jackie P. Williams PhD (Professor), Louis S. Constine MD (Professor of Radiation Oncology and Pediatrics Vice Chair) & Paul Okunieff MD

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  1. Michael T. Milano MD, PhD
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  2. Jackie P. Williams PhD
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  3. Louis S. Constine MD
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  4. Paul Okunieff MD
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Editors and Affiliations

  1. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Philip Rubin MD (Professor Emeritus, Chair Emeritus) & Paul Okunieff MD (Philip Rubin Professor of Radiation Oncology, Chair) (Professor Emeritus, Chair Emeritus) &  (Philip Rubin Professor of Radiation Oncology, Chair)

  2. Department of Radiation Oncology James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA

    Louis S. Constine MD (Professor of Radiation Oncology and Pediatrics, Vice Chair) (Professor of Radiation Oncology and Pediatrics, Vice Chair)

  3. Department of Radiation Oncology, University of North Carolina at Chapel Hill, Campus Box 7512, Chapel Hill, NC, 27599, USA

    Lawrence B. Marks MD (Professor and Chair) (Professor and Chair)

  4. Duke University Medical Center, P.O. Box 3085, Durham, NC, 27710, USA

    Lawrence B. Marks MD (Professor and Chair) (Professor and Chair)

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Milano, M.T., Williams, J.P., Constine, L.S., Okunieff, P. (2008). Late Toxicity from Hypofractionated Stereotactic Body Radiation. In: Rubin, P., Constine, L.S., Marks, L.B., Okunieff, P. (eds) Cured II ■ LENT Cancer Survivorship Research and Education. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76271-3_12

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