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Genome Mapping and Genomics in Animal-Associated Microbes pp 65–83Cite as

Mycobacterium avium subspecies paratuberculosis

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Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne’s disease in cattle and other domesticated and wild ruminant species. The organism and disease were first described over a century ago, and despite the considerable morbidity and mortality associated with Map infection in animal agriculture, relatively little is known about the molecular mechanisms of virulence and pathogenesis of infection or the population structure and molecular epidemiology of the bacterium. The description of the complete genome sequence of the K-10 strain of Map in 2005 has catalyzed and enabled research in these areas, particularly as relates to methods for strain differentiation and diagnostic test development. In the current chapter, we provide a post-genomics perspective on our current understanding of the bacterium and the disease it causes, and highlight our current understanding of the population structure of Map. Overall, the availability of the genome sequence of Map has provided a strong foundation for the rational development of the next generation of tools and techniques for the prevention and control of this devastating animal pathogen.

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Authors and Affiliations

  1. Department of Veterinary and Biomedical Sciences, Penn State, University Park, PA, USA

    Ling-Ling Li, Sagarika Kanjilal & Vivek Kapur

  2. Biomedical Genomics Center, University of Minnesota, St. Paul, MN, USA

    Sushmita Singh & Vivek Kapur

  3. US Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, IA, USA

    John Bannantine

  4. Department of Pharmacology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Sagarika Kanjilal

  5. Center for Infectious Disease Dynamics, Penn State, University Park, PA, USA

    Vivek Kapur

Authors
  1. Ling-Ling Li
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  2. Sushmita Singh
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  3. John Bannantine
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  4. Sagarika Kanjilal
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  5. Vivek Kapur
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Editor information

Editors and Affiliations

  1. Institute for Genome Sciences and Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21021, USA

    Vishvanath Nene

  2. Department of Genetics & Biochemistry, Clemson University, 111 Jordan Hall, Clemson, SC, 29634, USA

    Chittaranjan Kole

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© 2009 Springer-Verlag Berlin Heidelberg

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Li, LL., Singh, S., Bannantine, J., Kanjilal, S., Kapur, V. (2009). Mycobacterium avium subspecies paratuberculosis. In: Nene, V., Kole, C. (eds) Genome Mapping and Genomics in Animal-Associated Microbes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74042-1_2

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