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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

A review of quality of life (QOL) concerning the salivary glands may focus on treatment of a salivary gland tumor, or xerostomia as a side effect of radiotherapy.

Quality of life studies about treatment of salivary gland tumors mainly focus on facial nerve function after surgery with or without postoperative radiotherapy. Prospective longitudinal studies on QOL issues concerning radiotherapy for salivary gland tumors cannot be found in the literature. As an indirect indicator of QOL, treatment resulting in improvement of locoregional control, and risk factors such as comorbidity and treatment-related side effects may be studied. For parotid gland tumors, the main side effects are facial nerve dysfunction, hearing loss, xerostomia, and temporal bone necrosis. Side effects of treatment of the submandibular gland and the minor salivary gland tumors strongly relate to the location of the tumor, and the possible need for elective or curative treatment of the neck nodes.

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References

  • Anteunis LJC, Wanders SL, Hendriks JJT et al. (1994) A prospective longitudinal study on radiation-induced hearing loss. Am J Surg 168:408–411

    Article  PubMed  CAS  Google Scholar 

  • Beal KP, Singh B, Kraus D et al. (2003) Radiation-induced salivary gland tumors: a report of 18 cases and a review of the literature. Cancer J 9:467–471

    Article  PubMed  Google Scholar 

  • Beckhardt RN, Weber RS, Zane R et al. (1995) Minor salivary gland tumors of the palate: clinical and pathologic correlates of outcome. Laryngoscope 105:1155–1160

    Article  PubMed  CAS  Google Scholar 

  • Bhattacharyya N (2004) Survival and prognosis for cancer of the submandibular gland. J Oral Maxillofac Surg 62:427–430

    Article  PubMed  Google Scholar 

  • Bhattacharyya N, Fried MP (2005) Determinants of survival in parotid gland carcinoma: a population-based study. Am J Otolaryngol-Head Neck Med Surg 26:39–44

    Google Scholar 

  • Bhide SA, Harrington KJ, Nutting CM (2006) Otological toxic-ity after postoperative radiotherapy for parotid tumours. Clinical Oncol 19:77–82

    Article  Google Scholar 

  • Borggreven PA, Verdonck@@@de Leeuw IM, Muller MJ et al. (2007) Quality of life and functional status in patients with cancer of the oral cavity and oropharynx: pre@@@treatment values of a prospective study. Eur Arch Otorhinolaryngol 264:651–657

    Article  PubMed  Google Scholar 

  • Braam PM, Terhaard CH, Roesink JM et al. (2006) Intensity@@@modulated radiotherapy signifi cantly reduces xerostomia compared with conventional radiotherapy. Int J Radiat Oncol Biol Phys 66:975–980

    PubMed  Google Scholar 

  • Bragg CM, Conway J, Robinson MH (2002) The role of intensity@@@modulated radiotherapy in the treatment of parotid tumors. Int J Radiat Oncol Biol Phys 52:729–738

    Article  PubMed  Google Scholar 

  • Bron L P, O'Brien CJ (1997) Facial nerve function after parotidectomy. Arch Otolaryngol Head Neck Surg 123(10):1091–1096

    PubMed  CAS  Google Scholar 

  • Brown PD, Eshleman JS, Foote RL et al. (2000) An analysis of facial nerve function in irradiated and unirradiated facial nerve grafts. Int J Radiat Oncol Biol Phys 48(3):737–743

    PubMed  CAS  Google Scholar 

  • Carinci F, Farina A, Pelucchi S et al. (2001) Parotid gland carcinoma: 1987–1997 UICC T classifi cations compared for prognostic accuracy at 5 years. Eur Arch Otorhinolaryngol 258:150–154

    Article  PubMed  CAS  Google Scholar 

  • Carrillo JF, Vazquez R, Ramirez@@@Ortega M et al. (2007) Multivari ate prediction of the probability of recurrence in patients with carcinoma of the parotid gland. Cancer 109:2043–2051

    Article  PubMed  Google Scholar 

  • Chen AM, Bucci MK, Quivey JM et al. (2006) Long@@@term outcome of patients treated by radiation therapy alone for salivary gland carcinomas. Int J Radiation Oncology Biol Phys 67:1044–1050

    Google Scholar 

  • Chen AM, Granchi PJ, Garcia J et al. (2007) Local@@@regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy. Int J Radiat Oncol Biol Phys 67:982–987

    PubMed  Google Scholar 

  • Chen WC, Jackson A, Budnick AS et al. (2006) Sensorineural hearing loss in combined modality treatment of nasopha@@@ryngeal carcinoma. Cancer 106:820–829

    Article  PubMed  Google Scholar 

  • Chen WQQQC, Liao CQQQT, Tsai HQQQC et al. (1999) RadiationQQQinduced hearing impairment in patients treated for malignant parotid tumor. Ann Rhinol Laryngol 108:1159–1164

    CAS  Google Scholar 

  • Coulson S, O'Dwyer NJ, Adams RG et al. (2002) Expression of emotion and quality of life after facial nerve paralysis. Otol Neurotol 25:1014–1019

    Article  Google Scholar 

  • de Graeff A, Leeuw JRJ de, Ros, WJG et al. (2000) Pretreatment factors predicting quality of life after treatment for head and neck cancer. Head Neck 22:398–407

    Article  PubMed  Google Scholar 

  • Derks W, de Leeuw JR, Hordijk GJ et al. (2005) Reasons for nonQQQstandard treatment in elderly patients with advanced head and neck cancer. Eur Arch Otorhinolaryngol 262(1):21–26

    Article  PubMed  CAS  Google Scholar 

  • Dirix P, Nuyts S, Van den Bogaert W (2006) RadiationQQQinduced xerostomia in patients with head and neck cancer. Cancer 107:2525–2534

    Article  PubMed  Google Scholar 

  • Douglas JG, Silbergeld DL, Laramore GE (2004) Gamma Knife stereotactic radiosurgical boost for patients treated primarily with neutron radiotherapy for salivary gland neoplasms. Stereotact Funct Neurosurg 82:84–89

    Article  PubMed  Google Scholar 

  • Eisbruch A, Ten Haken RK, Kim HM et al. (1999) Dose, volume, and function relationships in parotid salivary glands following conformal and intensityQQQmodulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys 45:577–587

    PubMed  CAS  Google Scholar 

  • Ferrier MB, Spuesens EB, Le Cessie S et al. (2005) Comorbidity as a major risk factor for mortality and complications in head and neck surgery. Arch Otolaryngol Head Neck Surg 131:27–32

    Article  PubMed  Google Scholar 

  • Gallo O, Franchi A, Bianchi S et al. (1995) P53 oncoprotein expression in parotid gland carcinoma is associated with clinical outcome. Cancer 75:2037–2044

    Article  PubMed  CAS  Google Scholar 

  • Garden AS, elQQQNaggar AK, Morrison WH et al. (1997) Postoperative radiotherapy for malignant tumors of the parotid gland. Int J Radiat Oncol Biol Phys 37:79–85

    PubMed  CAS  Google Scholar 

  • Garden AS, Weber RS, Ang KK et al. (1994) Postoperative radiation therapy for malignant tumors of minor salivary glands. Outcome and patterns of failure. Cancer 73:2563–2569

    Article  PubMed  CAS  Google Scholar 

  • Garden AS, Weber RS, Morrison WH et al. (1995) The infl uQQQence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation. Int J Radiat Oncol Biol Phys 32:619–626

    Article  PubMed  CAS  Google Scholar 

  • Guida RA, Finn DG, Buchalter IH et al. (1990) Radiation injury to the temporal bone. Am J Otol 11:6–11

    PubMed  CAS  Google Scholar 

  • GuntinasQQQLichius O, Straesser A, Streppel M (2007) Quality of life after facial nerve repair. Laryngoscope 117:421–426

    Article  Google Scholar 

  • Honoré HB, Bentzen SM, Moller K et al (2002) SensoriQQQneural hearing loss after radiotherapy for nasopharyngeal carcinoma individualized risk estimation Radioth Oncol 65:9–16

    Article  Google Scholar 

  • Huber PE, Debus J, Latz D et al. (2001) Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam? Radiother Oncol 59:161–167

    Article  PubMed  CAS  Google Scholar 

  • Jaehne M, Roeser K, Jaekel T et al. (2005) Clinical and immunoQQQhistologic typing of salivary duct carcinoma. A report of 50 cases. Cancer 103:2526–2533

    Article  PubMed  Google Scholar 

  • JereczekQQQFossa BA, Zarowski A, Milani F et al. (2003) RadiotherapyQQQinduced ear toxicity. Cancer Treat Rev 29:417–430

    Article  Google Scholar 

  • Jones AS, Beasley NJP, Houghton DJ et al. (1998) Tumours of the minor salivary glands. Clin Otolaryngol 23:27–33

    Article  PubMed  CAS  Google Scholar 

  • Kam MK, Leung SF, Zee B et al. (2007) Prospective randomized study of intensityQQQmodulated radiotherapy on salivary gland function in earlyQQQstage nasopharyngeal carcinoma patients. J Clin Oncol 25:4873–4879

    Article  PubMed  Google Scholar 

  • Kaplan MH, Feinstein AR (1974) The importance of classifying initial coQQQmorbidity in evaluating the outcome of diabetes mellitus. J Chronic Dis 27(7–8):387–404

    Article  PubMed  CAS  Google Scholar 

  • Kerrebijn JD, Freeman JL (1988) Facial nerve reconstruction: outcome and failures. J Otolaryngol 27(4):183–186

    Google Scholar 

  • Kirkbride P, Liu FF, O'Sullivan B et al. (2001) Outcome of curative management of malignant tumors of the parotid gland. J Otolaryngol 30:271–279

    Article  PubMed  CAS  Google Scholar 

  • Koul R, Dubey A, Butler J et al. (2007) Prognostic factors depic ting diseaseQQQspecifi c survival in parotidQQQgland tumors. Int J Radiat Oncol Biol Phys 68:714–718

    PubMed  Google Scholar 

  • Kwok HCK, Morton R, Chaplin JM et al. (2002) Quality of life after parotid and temporal bone surgery for cancer. Laryngoscope 112:820–833

    Article  PubMed  Google Scholar 

  • LamersQQQKuijper E, Schwarz M, Rasch C et al. (2007) IntensityQQQmodulated vs. conventional radiotherapy of parotid gland tumors: potential impact on hearing loss. Med Dosim 32:237–245

    Article  Google Scholar 

  • Laramore GE, Krall JM, Griffi n TW et al. (1993) Neutron versus photon irradiation for unresectable salivary gland tumors: fi nal report of an RTOGQQQMRC randomized clinical trial. Int J Radiat Oncol Biol Phys 235–240

    Google Scholar 

  • Lee TK, Rosen II, Gibbons JP et al. (2008) Helical tomotherapy for parotid gland tumors. Int J Radiat Oncol Biol Phys 70:883–891

    PubMed  Google Scholar 

  • Lim JJ, Kang S, Lee MR et al. (2003) Expression of vascular endothelial growth factor in salivary gland carcinomas and its relation to p53, KiQQQ67 and prognosis. J Oral Pathol Med 32:552–561

    Article  PubMed  Google Scholar 

  • Lopes MA, Santos GC, Kowalski LP (1998) Multivariate survival analysis of 128 cases of oral cavity minor salivary gland carcinomas. Head Neck 20:699–706

    Article  PubMed  CAS  Google Scholar 

  • Low WK, Toh ST, Wee J et al. (2006) Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study. J Clin Oncol 24:1904–1909

    Article  PubMed  Google Scholar 

  • Luukkaa H, Klemi P, Hirsimali P et al. (2008) Matrix metalloQQQproteinase (MMP)QQQ1, QQQ9, and QQQ13 as prognostic factors in salivary gland cancer. Acta OtoQQQLaryngologica 128:482–490

    Article  CAS  Google Scholar 

  • Magnano M, Gervasio CF, Cravero L et al. (1999) Treatment of malignant neoplasms of the parotid gland. Otolaryngol Head Neck Surg 121(5):627–632

    Article  PubMed  CAS  Google Scholar 

  • Mendenhall WM, Morris CG, Amdur RJ et al. (2005) Radiotherapy alone or combined with surgery for salivary gland carcinoma. Cancer 103:2544–2550

    Article  PubMed  Google Scholar 

  • MurdochQQQKinch CA, Kim HM, Vineberg KA et al. (2008) DoseQQQeffect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 72(2):373–82

    Google Scholar 

  • Nishimura R, Baba Y, Murakimi R et al. (1997) MR evaluation of radiation otomastoiditis. Int J Radiat Oncol Biol Phys 39:155–160

    PubMed  CAS  Google Scholar 

  • North CA, Lee DJ, Piantadosi S et al. (1990) Carcinoma of the major salivary glands treated by surgery or surgery plus postoperative radiotherapy. Int J Radiat Oncol Biol Phys 18:1319–1326

    PubMed  CAS  Google Scholar 

  • Nutting CM, Rowbottom CG, Cosgrove VP et al. (2001) Optimisation of radiotherapy for carcinoma of the parotid gland: a comparison of conventional, threeQQQdimensional conformal, and intensityQQQmodulated techniques. Radiother Oncol 60:163–172

    Article  PubMed  CAS  Google Scholar 

  • Pan CC, Eisbruch A, Lee SJ et al. (2005) Prospective study of inner ear radiation dose and hearing loss in headQQQandQQQneck cancer patients. Int J Radiat Oncol Biol Phys 61:1393–1402

    PubMed  Google Scholar 

  • Parsons JT, Mendenhall WM, Stringer SP et al. (1996) Management of minor salivary gland carcinomas. Int J Radiat Oncol Biol Phys 35:443–454

    Article  PubMed  CAS  Google Scholar 

  • Pathak I, Bryce G (2000) Temporal bone necrosis: diagnosis, classifi cation, and management. Otolaryngol Head Neck Surg 123:252–257

    Article  PubMed  CAS  Google Scholar 

  • Piccirillo JF, Costas I (2004) The impact of comorbidity on outcomes. ORL 66:180–185

    Article  PubMed  Google Scholar 

  • Pohar S, Gay H, Rosenbaum P et al. (2005) Malignant parotid tumors: presentation, clinical/pathologic prognostic factors, and treatment outcomes. Int J Radiat Oncol Biol Phys 61:112–118

    PubMed  Google Scholar 

  • Pommier P, Liebsch NJ, Deschler DG et al. (2006) Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 132:1242–1249

    Article  PubMed  Google Scholar 

  • Poulsen MG, Pratt GR, Kynaston B et al. (1992) Prognostic variables in malignant epithelial tumors of the parotid. Int J Radiat Oncol Biol Phys 23:327–330

    PubMed  CAS  Google Scholar 

  • Press MF, Pike MC, Hung G et al. (1994) Amplifi cation and overexpression of HERQQQ2/neu in carcinomas of the salivary gland: correlation with poor prognosis. Cancer Res 54:5675–5682

    PubMed  CAS  Google Scholar 

  • Raaijmakers E, Engelen AM (2002) Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation? A systematic review of the literature. Radioth Oncol 65:1–7

    Article  Google Scholar 

  • Reddy PG, Arden RL, Mathog RH (1999) Facial nerve rehabilitation after radical parotidectomy. Laryngoscope 109(6):894–899

    Article  PubMed  CAS  Google Scholar 

  • Régis de Brito Santos I, Kowalski L P, Cavalcante de Araujo V et al. (2001) Multivariate analysis of risk factors for neck metastases in surgically treated parotid carcinoma. Arch Otolaryngol Head Neck Surg 127:46–60

    Google Scholar 

  • Roesink J, Moerland M, Battermann J et al. (2001) Quantative doseQQQvolume response analysis of changes in parotid gland function after radiotherapy in the headQQQandQQQneck region. Int J Radiat Oncol Biol Phys 51:938–946

    PubMed  CAS  Google Scholar 

  • Rogers SN, Aziz A, Lowe D et al. (2006) Feasibility study of the retrospective use of the Adult Comorbidity Evaluation index (ACEQQQ27) in patients with cancer of the head and neck who had radiotherapy. Br J Oral Maxillofac Surg 44(4):283–8

    Article  PubMed  Google Scholar 

  • Sanabria A, Carvalho AL, Vartanian JG et al. (2007) Comorbidity is a prognostic factor in elderly patients with head and neck cancer. Ann Surg Oncol 14(4):1449–1457

    Article  PubMed  Google Scholar 

  • Schramm VL, Imola MJ (2001) Management of nasophaQQQryngeal salivary gland malignancy. Laryngoscope 111:1533–1544

    Article  PubMed  Google Scholar 

  • SchulzQQQErtner D, Nikoghosyan A, Jäkel et al. (2003) Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas. Int J Radiat Oncol Biol Phys 56:391–398

    Article  Google Scholar 

  • Schwarz S, Ettl T, Kleinsasser N et al. (2008) Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors. Oral Oncol 44:563–570

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH (1986) Salivary neoplasms: overview of a 35QQQyear experience with 2,807 patients. Head Neck Surg 8:177–184

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH, Armstrong J, Harrison L et al. (1989) Carcinoma of major salivary glands. Arch Otolaryngol Head Neck Surg 115:316–321

    PubMed  CAS  Google Scholar 

  • Spiro JD, Spiro RH (2003) Cancer of the parotid gland: role of the 7th nerve preservation. World J Surg 27(7):863–867

    Article  PubMed  Google Scholar 

  • Storey MR, Garden AS, Morrison WH et al. (2001) Postoperative radiotherapy for malignant tumors of the submandibular gland. Int J Radiat Oncol Biol Phys 51:952–958

    PubMed  CAS  Google Scholar 

  • Sun EC, Curtis R, Melbye M et al. (1999) Salivary gland cancer in the United States. Cancer Epidemiol Biomark Prev 8:1095–1100

    CAS  Google Scholar 

  • Swanson GM, Burns PB (1997) Cancers of the salivary gland: workplace risk among women and men. Ann Epidemiol 7:639–374

    Article  Google Scholar 

  • Terell JE, Ronis DL, Fowler KE et al. (2004) Clinical predictors of quality of life in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 130:401–408

    Article  Google Scholar 

  • Terhaard C, Lubsen H, Tan B et al. (2006) Facial nerve function in carcinoma of the parotid gland. Eur J Cancer 42(16): 2744–2750

    Article  PubMed  Google Scholar 

  • Terhaard CHJ, Lubsen H, Rasch CRN et al. (2005) The role of radiotherapy in the treatment of malignant salivary gland tumours. Int J Radiat Oncol Biol Phys 61(1):103–111

    PubMed  Google Scholar 

  • Terhaard CHJ, Lubsen H, Van der Tweel et al. (2004) Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch Head and Neck Oncology Cooperative Group. Head Neck 26:681–693

    Article  PubMed  Google Scholar 

  • Terhaard CHJ, van der Schroeff MP, Schie K van et al. (2008) Prognostic role of comorbidity in salivary gland carcinoma. Cancer 113:1572–1576

    Article  PubMed  Google Scholar 

  • Therkildsen MH, Christensen M, Andersen LJ et al. (1998) Salivary gland carcinomas—prognostic factors. Acta Oncol 37:701–713

    Article  PubMed  CAS  Google Scholar 

  • Vander Poorten V, Balm AJ, Hilgers FJ et al. (1999) The development of a prognostic score for patients with parotid carcinoma. Cancer 85(9):2057–2067

    Google Scholar 

  • Vander Poorten VLM, Hart AAM, Van der Laan BFAM et al. (2003) Prognostic index for patients with parotid carcinoma. External validation using the nationwide 1985–1994 Dutch Head and Neck Oncology Cooperative Group Database. Cancer 97:1453–1463

    Article  Google Scholar 

  • Yaparpalvi R, Fontenla D P, Tyerech SK et al. (1998) Parotid gland tumors: a comparison of postoperative radiotherapy techniques using three dimensional (3D) dose distributions and doseQQQvolume histograms (DVHS). Int J Radiat Oncol Biol Phys 40:43–49

    Article  PubMed  CAS  Google Scholar 

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Terhaard, C. (2009). Salivary Glands and Quality of Life. In: Harari, P.M., Connor, N.P., Grau, C. (eds) Functional Preservation and Quality of Life in Head and Neck Radiotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73232-7_7

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