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Oropharynx: Epidemiology and Treatment Outcome

  • Chapter
Functional Preservation and Quality of Life in Head and Neck Radiotherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Oropharynx squamous cell carcinoma (OPSCC) has emerged as one of the most common malignancies in the head and neck (HN) sites. Around 123,000 new cases of oropharyngeal (OP) cancers are estimated to occur annually worldwide, resulting in 79,000 annual deaths (Parkin et al. 2001). In the United States, the incidence of OP cancers in 2008 is estimated to be 35,310 new cases, from which 7,590 deaths will occur (Jemal et al. 2008). The oropharynx, which comprises of the soft palate, uvula, tonsillar fossa and pillars, glossotonsillar sulci, lateral and posterior pharyngeal wall, vallecula, and base of tongue, harbors a rich lymphatic network. Therefore, tumors arising from this region are likely to have early nodal involvement and ˜60% of these patients present with stage III—IV tumors at diagnosis (Greene et al. 2002). The treatment of OP cancers has evolved over time. Although either surgery or radiation therapy (RT) remains the main treatment modality for early-stage OP cancers, concurrent chemoradiation therapy (CRT) has largely replaced RT alone for locally advanced neoplasms. Recent advances in RT techniques and molecular technologies have ushered in a new age of novel therapy for OP cancers, which holds promise for a better outcome with potentially less normal tissue toxicity. In this chapter, we will focus on the new developments in epidemiology and treatment approaches for OPSCC.

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Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University Cancer Center, 875 Blake Wilbur Drive, Stanford, CA, 04305-5847, USA

    Edith Filion MD & Quynh-Thu Le MD

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  1. Edith Filion MD
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  2. Quynh-Thu Le MD
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Editors and Affiliations

  1. Department of Human Oncology, University of Wisconsin School of Medicine, 600 Highland Avenue, K4/332, Madison, WI, 53792, USA

    P. M. Harari MD

  2. Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin Medical School, 600 Highland Avenue K4/711, Madison, WI, 53792-7375, USA

    N. P. Connor PhD

  3. Department of Oncology, Aarhus University Hospital, 44 Nøerrebrogade, Building 5, Aarhus C, DK-8000, Denmark

    C. Grau MD

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Filion, E., Le, QT. (2009). Oropharynx: Epidemiology and Treatment Outcome. In: Harari, P.M., Connor, N.P., Grau, C. (eds) Functional Preservation and Quality of Life in Head and Neck Radiotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73232-7_2

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  • DOI: https://doi.org/10.1007/978-3-540-73232-7_2

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