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Protein-Protein Interactions as New Drug Targets pp 3–14Cite as

A-Kinase Anchoring Proteins as the Basis for cAMP Signaling

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 186))

Abstract

Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly. Subcellular targeting through the association with adaptor and scaffolding proteins has emerged as a key mechanism by which cells maintain signaling specificity. Compartmentation of cAMP signaling is maintained by the clustering of cAMP signaling enzymes in discrete units by the scaffolding protein A-kinase anchoring proteins (AKAP). In doing so, AKAPs provide the molecular architecture for the cAMP micordomains that underlie the spacial-temporal control of cAMP signaling.

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Abbreviations

PKA:

cAMP-dependent protein kinase

C:

PKA catalytic subunit

RI:

PKA regulatory subunit type I

RII:

PKA regulatory subunit type II

AKAP:

A-kinase anchoring protein

PDE:

Phosphodiesterase

RyR:

Ryanodine receptor

PP2A:

Protein phosphatase 2A

Epac:

Exchange protein activated by cAMP

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Author information

Authors and Affiliations

  1. Pat and Jim Calhoun Center for Cardiology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farminton, CT, 06030, USA

    K. L. Dodge-Kafka

  2. Department of Cell and Developmental Biology, Heart Research Center, Oregon Health & Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA

    A. Bauman & M. S. Kapiloff

Authors
  1. K. L. Dodge-Kafka
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  2. A. Bauman
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  3. M. S. Kapiloff
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Editor information

Editors and Affiliations

  1. Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany

    Enno Klussmann

  2. The Vollum Institute, Oregon Health & Science University, Medical Research Bldg, Rm 322D 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    John Scott Ph.D.

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Dodge-Kafka, K.L., Bauman, A., Kapiloff, M.S. (2008). A-Kinase Anchoring Proteins as the Basis for cAMP Signaling. In: Klussmann, E., Scott, J. (eds) Protein-Protein Interactions as New Drug Targets. Handbook of Experimental Pharmacology, vol 186. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72843-6_1

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