Abstract
Was bedeutet Toleranz, wie sind die Mechanismen der Transplantatabstoßung, was versteht man unter Allergien und Autoimmunität und welche Mechanismen liegen ihnen zugrunde? Dieses Kapitel gibt mit Bezug zu neuen Erkenntnissen auf dem Gebiet der T-Zell Forschung einen Einblick in grundlegende regulatorische und mechanistische Zusammenhänge, die den Fragen zugrunde liegen. Es werden verschiedene Typen von Allergien vorgestellt und anhand von Beispielen erklärt. Aber auch HIV und AIDS sind in diesem Kapitel hinsichtlich des Aufbaus von HI-Viren, des viralen Lebenszyklus, des klinischen Verlaufs und therapeutischer Aspekte ein Thema.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Spezielle Literatur
Adams TE (1990) Tolerance to self-antigens in transgenic mice. Mol Biol Med 7:341–357
Chiu YL, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, Greene WC (2005) Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature 435:108–114
Cramer DV (2000) Natural antibodies and the host immune responses to xenografts. Xenotransplantation 7:83–92
de Bie P, van de Sluis B, Burstein E, Duran KJ, Berger R, Duckett CS, Wijmenga C, Klomp LW (2006) Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J 398:63–71
Ferry H, Leung JC, Lewis G, Nijnik A, Silver K, Lambe T, Cornall and RJ (2006) B-cell tolerance. Transplantation 81:308–315
Fleming SD (2006) Natural antibodies, autoantibodies and complement activation in tissue injury. Autoimmunity 39:379–386
Ganesh L, Burstein E, Guha-Niyogi A, Louder MK, Mascola JR, Klomp LW, Wijmenga C, Duckett CS, and Nabel GJ (2003) The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. Nature 426:853–857
Goudy KS, Tisch R (2005) Immunotherapy for the prevention and treatment of type 1 diabetes. Int Rev Immunol 24:307–326
Harris RS, Liddament MT (2004) Retroviral restriction by APOBEC proteins. Nat Rev Immunol 4:868–877
Hoglund P (2006) Induced peripheral regulatory T cells: the family grows larger. Eur J Immunol 36:264–266
Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057–1061
Jiang S, Golshayan D, Tsang J, Lombardi G, Lechler RI (2006) In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance. In .Immunopharmacol 20;6:1879–1882
Jordan MS, Boesteanu A, Reed AJ, Petrone AL, Holenbeck AE, Lerman MA, Naji A, Caton AJ (2001) Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2:301–306
Kanwar JR (2005) Anti-inflammatory immunotherapy for multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) disease. Curr Med Chem 12:2947–2962
Lanzavecchia A, Sallusto F (2007) Toll-like receptors and innate immunity in B-cell activation and antibody responses. Curr Opin Immunol 19:268–274
Lechler RI, Sykes M, Thomson AW, Turka LA (2005) Organ transplantation – how much of the promise has been realized? Nat Med 11:605–613
Milland J, Sandrin MS (2006) ABO blood group and related antigens, natural antibodies and transplantation. Tissue Antigen. 68:459–466
Nemazee D (2006) Receptor editing in lymphocyte development and central tolerance. Nat Rev Immunol 6:728–740
O´Shea JJ Immunoregulation. (2001) Nature Encyclopedia of life sciences 1–10
Picca CC, Larkin J, Boesteanu A, Lerman MA, Rankin AL, Caton AJ (2006) Role of TCR specificity in CD4+ CD25+ regulatory T-cell selection. Immunol Rev 212:74–85
Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T (2006) Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Re 212:8–27
Siliciano RF (2001) Acquired immune deficiency syndrome (AIDS). Nature Encyclopedia of life sciences 1–12
Simpson E, Scott D, Chandler P (1997) The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. Annu Rev Immunol 15:39–61.:39–61
Stockinger B, Veldhoen M (2007) Differentiation and function of Th17 T cells. Curr Opin Immunol 19:281–286
Stoll G, Jander S. Microglia (2001) Nature Encyclopedia of life sciences 1–6
Thmas WR Hypersensitivity. Immunological. (2001) Nature Encyclopedia of life sciences 1–9
Verkoczy LK, Martensson AS, Nemazee D (2004) The scope of receptor editing and its association with autoimmunity. Curr Opin Immunol 16:808–814
von Boehmer H, Teh HS, Kisielow P (1989) The thymus selects the useful, neglects the useless and destroys the harmful. Immunol Today 10:57–61
Zou W (2006) Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6:295–307
Zouali M (2001) Immunological tolerance: Mechanisms. Nature Encyclopedia of life sciences 1–9
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
(2008). Toleranz, Transplantatabstoßung, Allergie, Autoimmunität, HIV und AIDS. In: Neumann, J. (eds) Immunbiologie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72569-5_6
Download citation
DOI: https://doi.org/10.1007/978-3-540-72569-5_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-72568-8
Online ISBN: 978-3-540-72569-5
eBook Packages: Life Science and Basic Disciplines (German Language)