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Acute Leukemias pp 229–236Cite as

The Role of Autologous Stem Cell Transplantation in the Management of Acute Lymphoblastic Leukemia in Adults

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Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

Abstract

Recent treatment strategies for adult acute lymphoblastic leukemia (ALL) have resulted in improved complete remission (CR) rates of 80–90% [1–3]. However, longterm disease-free survival (DFS) rates have remained disappointingly low at 30–40%. Current research efforts are focused on an improved understanding of the biology of the disease, and innovative postremission strategies that will prolong disease-free duration. Stem cell transplantation (SCT) is one strategy that may improve disease outcome. Allogeneic SCT has been demonstrated to improve DFS in high-risk ALL patients in multiple large series. High risk is defined by specific biologic and clinical features that have been noted to consistently influence the outcome of adult ALL (Table 18.1). Age greater than 60 years, an elevated white blood cell count at presentation, failure to achieve clinical remission within the first 4 weeks of treatment, and specific recurring cytogenetic abnormalities are all considered adverse clinical features. In a multivariate analysis of risk factors in adult ALL, karyotype was identified as the most important factor for DFS [4].

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Authors and Affiliations

  1. Section of Blood and Marrow Transplantation, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Partow Kebriaei & Sergio Giralt

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  1. Partow Kebriaei
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  2. Sergio Giralt
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© 2008 Springer Berlin Heidelberg

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Kebriaei, P., Giralt, S. (2008). The Role of Autologous Stem Cell Transplantation in the Management of Acute Lymphoblastic Leukemia in Adults. In: Acute Leukemias. Hematologic Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72304-2_18

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  • DOI: https://doi.org/10.1007/978-3-540-72304-2_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-72302-8

  • Online ISBN: 978-3-540-72304-2

  • eBook Packages: MedicineMedicine (R0)

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