Abstract
Type I interferons (IFN-I) orchestrate numerous biological and cellular processes and are essential elements during host antiviral defense. After recognition of highly conserved virus signatures, a complex network of signaling events is rapidly initiated and leads to IFN-I synthesis. These cytokines directly induce a strong antiviral state and exert several immune-regulatory actions aimed at preventing virus spread. On the other hand, viruses evolved to evade or subvert the IFN-I system for their own benefit. In the present article, we review selective aspects of IFN-I induction and functions during several viral infections and discuss the beneficial and detrimental roles of IFN-I illustrated during lymphocytic choriomeningitis virus (LCMV) infection in its natural host, the mouse.
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© 2007 Springer-Verlag Berlin Heidelberg
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Zuniga, E.I., Hahm, B., Oldstone, M. (2007). Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator. In: Pitha, P.M. (eds) Interferon: The 50th Anniversary. Current Topics in Microbiology and Immunology, vol 316. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71329-6_16
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DOI: https://doi.org/10.1007/978-3-540-71329-6_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-71328-9
Online ISBN: 978-3-540-71329-6
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