Abstract
The recognition of viral nucleic acids with pattern recognition receptors (PRRs) is the first step in inducing the innate immune system. Type I interferons (IFNs), central mediators in antiviral innate immunity, along with other cytokines and chemokines, disrupt virus replication. Recent studies indicated at least two distinct pathways for the induction of type I IFN by viral infection. Toll-like receptors (TLRs) are extracellular or endosomal PRRs for microbial pathogens, whereas retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are novel intracellular PRRs for the viral dsRNA. In this review, we describe the distinct mechanisms inducing type I IFNs through TLRs and RIG-I/MDA5 pathways.
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© 2007 Springer-Verlag Berlin Heidelberg
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Onomoto, K., Yoneyama, M., Fujita, T. (2007). Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases. In: Pitha, P.M. (eds) Interferon: The 50th Anniversary. Current Topics in Microbiology and Immunology, vol 316. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71329-6_10
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DOI: https://doi.org/10.1007/978-3-540-71329-6_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-71328-9
Online ISBN: 978-3-540-71329-6
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