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Dendritic Cells pp 115–136Cite as

Dendritic Cells in Rhinitis

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 188))

Abstract

Dendritic cells (DCs) play an important role in all kind of rhinitis and sinusitis. One of the most important upper airway diseases is allergic rhinitis. DCs are the professional antigen presenting cells that have the capacity to present antigen to naive-T cells and T-effector cells. In the context of a broad spectrum of rhinitis, from allergic rhinitis via upper respiratory tract virus infection to chronic sinusitis, DCs have an important role in the immunological outcome of the disease. Studies in humans and animal models that have highlighted the role of DC were evaluated. This article reviews recent information on the involvement of DC in rhinitis, and the mechanisms by which DC could be employed as targets for therapeutic intervention.

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Authors and Affiliations

  1. Department of Pulmonary Medicine, Erasmus M.C. Dr. Molerwaterplein, Rotterdam, GE, 50, 3015, The Netherlands

    Alex KleinJan & Bart N. Lambrecht

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  1. Alex KleinJan
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  2. Bart N. Lambrecht
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Correspondence to Alex KleinJan or Bart N. Lambrecht .

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Editors and Affiliations

  1. DIIID, King's College, London School of Medicine, Guy's Hospital, London, UK

    Giovanna Lombardi (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation) (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation)

  2. 5th Floor Hodgkin Building, School of Biomedical and Health Sciences, King's College London, London, SE1 1UL, United Kingdom

    Yanira Riffo-Vasquez (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division) (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division)

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KleinJan, A., Lambrecht, B.N. (2009). Dendritic Cells in Rhinitis. In: Lombardi, G., Riffo-Vasquez, Y. (eds) Dendritic Cells. Handbook of Experimental Pharmacology, vol 188. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71029-5_6

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