Plant-produced Microbial Vaccines

Volume 332 of the series Current Topics in Microbiology and Immunology pp 1-11

Plant Vaccines: An Immunological Perspective

  • D. C. HooperAffiliated withDepartment of Microbiology and Immunology, Emory University School of MedicineAssociate Professor, Center for Neurovirology, Kimmel Cancer Center, Thomas Jefferson University

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The advent of technologies to express heterologous proteins in planta has led to the proposition that plants may be engineered to be safe, inexpensive vehicles for the production of vaccines and possibly even vectors for their delivery. The immunogenicity of a variety of antigens of relevance to vaccination expressed in different plants has been assessed. The purpose of this article is to examine the utility of plant-expression systems in vaccine development from an immunological perspective.