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Measles pp 13–30Cite as

Measles Virus Receptors

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 329))

Measles virus (MV) has two envelope glycoproteins, the hemagglutinin (H) and fusion protein, which are responsible for attachment and membrane fusion, respectively. Signaling lymphocyte activation molecule (SLAM, also called CD150), a membrane glycoprotein expressed on immune cells, acts as the principal cellular receptor for MV, accounting for its lymphotropism and immunosuppressive nature. MV also infects polarized epithelial cells via an as yet unknown receptor molecule, thereby presumably facilitating transmission via aerosol droplets. Vaccine and laboratory-adapted strains of MV use ubiquitously expressed CD46 as an alternate receptor through amino acid substitutions in the H protein. The crystal structure of the H protein indicates that the putative binding sites for SLAM, CD46, and the epithelial cell receptor are strategically located in different positions of the H protein. Other molecules have also been implicated in MV infection, although their relevance remains to be determined. The identification of MV receptors has advanced our understanding of MV tropism and pathogenesis.

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Authors and Affiliations

  1. Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, 812-8582, Japan

    Y. Yanagi, M. Takeda, S. Ohno & T. Hashiguchi

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  1. Y. Yanagi
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  2. M. Takeda
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  3. S. Ohno
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  4. T. Hashiguchi
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Correspondence to Y. Yanagi .

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  1. Department of Molecular Microbiology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA

    Diane E. Griffin

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Yanagi, Y., Takeda, M., Ohno, S., Hashiguchi, T. (2009). Measles Virus Receptors. In: Griffin, D.E., Oldstone, M.B.A. (eds) Measles. Current Topics in Microbiology and Immunology, vol 329. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70523-9_2

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