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References

  1. Abran D et al (1995) Characterization and ontogeny of PGE2 and PGF2 alpha receptors on the retinal ­vasculature of the pig. Prostaglandins 50:253–267

    PubMed  CAS  Google Scholar 

  2. Abran D et al (1997) Characterization and regulation of prostaglandin E2 receptor and receptor-coupled functions in the choroidal vasculature of the pig during development. Circ Res 80:463–472

    PubMed  CAS  Google Scholar 

  3. Akarsu C et al (2004) Short-term effect of latanoprost on ocular circulation in ocular hypertension. Clin Experiment Ophthalmol 32:373–377

    PubMed  Google Scholar 

  4. Alm A (1972) Effects of norepinephrine, angiotensin, dihydroergotamine, papaverine, isoproterenol, histamine, nicotinic acid, and xanthinol nicotinate on retinal oxygen tension in cats. Acta Ophthalmol (Copenh) 50:707–719

    CAS  Google Scholar 

  5. Altan-Yaycioglu R et al (2001) The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study. Eur J Ophthalmol 11:37–46

    PubMed  CAS  Google Scholar 

  6. Araie M, Muta K (1997) Effect of long-term topical betaxolol on tissue circulation in the iris and optic nerve head. Exp Eye Res 64:167–172

    PubMed  CAS  Google Scholar 

  7. Arend O et al (1998) The acute effect of topical beta-adrenoreceptor blocking agents on retinal and optic nerve head circulation. Acta Ophthalmol Scand 76:43–49

    PubMed  CAS  Google Scholar 

  8. Arend O et al (2003) Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients. Acta Ophthalmol Scand 81:474–479

    PubMed  CAS  Google Scholar 

  9. Astin M et al (1994) Role of nitric oxide in PGF2 alpha-induced ocular hyperemia. Exp Eye Res 59:401–407

    PubMed  CAS  Google Scholar 

  10. Ayajiki K et al (2000) Evidence for nitroxidergic innervation in monkey ophthalmic arteries in vivo and in vitro. Am J Physiol Heart Circ Physiol 279:H2006–H2012

    PubMed  CAS  Google Scholar 

  11. Ayajiki K et al (2001) Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries. Eur J Pharmacol 423:179–183

    PubMed  CAS  Google Scholar 

  12. Barnes GE et al (2000) Increased optic nerve head blood flow after 1 week of twice daily topical brinzolamide treatment in Dutch-belted rabbits. Surv Ophthalmol 44(Suppl 2):S131–S140

    PubMed  Google Scholar 

  13. Baurmann H et al (1986) Simultaneous study of ocular vascular reactions of the anterior and posterior segments following clonidine and propranolol in normotensive and hypertensive experimental animals. Klin Monbl Augenheilkd 189:467–476

    PubMed  CAS  Google Scholar 

  14. Beano F et al (2001) An evaluation of the effect of unoprostone isopropyl 0.15% on ocular hemodynamics in normal-tension glaucoma patients. Graefes Arch Clin Exp Ophthalmol 239:81–86

    PubMed  CAS  Google Scholar 

  15. Becker B (1954) Decrease in intraocular pressure in man by a carbonic anhydrase inhibitor, diamox; a preliminary report. Am J Ophthalmol 37:13–15

    PubMed  CAS  Google Scholar 

  16. Benedito S et al (1991) Role of the endothelium in acetylcholine-induced relaxation and spontaneous tone of bovine isolated retinal small arteries. Exp Eye Res 52:575–579

    PubMed  CAS  Google Scholar 

  17. Bergstrand IC et al (2001) Timolol increased retrobulbar flow velocities in untreated glaucoma eyes but not in ocular hypertension. Acta Ophthalmol Scand 79:455–461

    PubMed  CAS  Google Scholar 

  18. Bergstrand IC et al (2002) Dorzolamide and ocular blood flow in previously untreated glaucoma patients: a controlled double-masked study. Acta Ophthalmol Scand 80:176–182

    PubMed  CAS  Google Scholar 

  19. Bill A (1979) Effects of indomethacin on regional blood flow in conscious rabbits – a microsphere study. Acta Physiol Scand 105:437–442

    PubMed  CAS  Google Scholar 

  20. Bloom AH et al (1997) Effect of one week of levobunolol HCl 0.5% on the human retinal circulation. Curr Eye Res 16:191–196

    PubMed  CAS  Google Scholar 

  21. Boger RH, Bode-Boger SM (2000) Asymmetric dimethylarginine, derangements of the endothelial nitric oxide synthase pathway, and cardiovascular diseases. Semin Thromb Hemost 26:539–545

    PubMed  CAS  Google Scholar 

  22. Bosem ME et al (1992) Short-term effects of levobunolol on ocular pulsatile flow. Am J Ophthalmol 114:280–286

    PubMed  CAS  Google Scholar 

  23. Brazitikos PD et al (1993) Microinjection of L-lactate in the preretinal vitreous induces segmental vasodilation in the inner retina of miniature pigs. Invest Ophthalmol Vis Sci 34:1744–1752

    PubMed  CAS  Google Scholar 

  24. Bruinink A et al (1986) Catecholaminergic binding sites in cat retina, pigment epithelium and choroid. Exp Eye Res 43:147–151

    PubMed  CAS  Google Scholar 

  25. Buerk DG et al (1996) Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvasc Res 52:13–26

    PubMed  CAS  Google Scholar 

  26. Bursell SE et al (1995) The in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci 36:596–607

    PubMed  CAS  Google Scholar 

  27. Carenini AB et al (1994) Differences in the longterm effect of timolol and betaxolol on the pulsatile ocular blood flow. Surv Ophthalmol 38(Suppl):S118–S124

    PubMed  Google Scholar 

  28. Carlsson AM et al (2000) The effect of brimonidine tartrate on retinal blood flow in patients with ocular hypertension. Am J Ophthalmol 129:297–301

    PubMed  CAS  Google Scholar 

  29. Chakravarthy U et al (1992) The effect of endothelin 1 on the retinal microvascular pericyte. Microvasc Res 43:241–254

    PubMed  CAS  Google Scholar 

  30. Chakravarthy U et al (1994) Immunoreactive endothelin distribution in ocular tissues. Invest Ophthalmol Vis Sci 35:2448–2454

    PubMed  CAS  Google Scholar 

  31. Chakravarthy U et al (1995) Nitric oxide synthase activity and expression in retinal capillary endothelial cells and pericytes. Curr Eye Res 14:285–294

    PubMed  CAS  Google Scholar 

  32. Chauhan BC (2008) Endothelin and its potential role in glaucoma. Can J Ophthalmol 43:356–360

    PubMed  Google Scholar 

  33. Chauhan BC et al (2004) Model of endothelin-1-induced chronic optic neuropathy in rat. Invest Ophthalmol Vis Sci 45:144–152

    PubMed  Google Scholar 

  34. Chemtob S et al (1991) Differences in the effects in the newborn piglet of various nonsteroidal antiinflammatory drugs on cerebral blood flow but not on cerebrovascular prostaglandins. Pediatr Res 30:106–111

    PubMed  CAS  Google Scholar 

  35. Chen Z et al (1998) Histochemical mapping of NADPH-diaphorase in monkey and human eyes. Curr Eye Res 17:370–379

    PubMed  CAS  Google Scholar 

  36. Chiou GC, Chen YJ (1993) Effects of antiglaucoma drugs on ocular blood flow in ocular hypertensive rabbits. J Ocul Pharmacol 9:13–24

    PubMed  CAS  Google Scholar 

  37. Chun MH et al (1999) Light and electron microscopical analysis of nitric oxide synthase-like immuno­reactive neurons in the rat retina. Vis Neurosci 16:379–389

    PubMed  CAS  Google Scholar 

  38. Cioffi GA et al (1995) An in vivo model of chronic optic nerve ischemia: the dose-dependent effects of endothelin-1 on the optic nerve microvasculature. Curr Eye Res 14:1147–1153

    PubMed  CAS  Google Scholar 

  39. Costagliola C et al (2007) Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol. Br J Clin Pharmacol 63:376–379

    PubMed  CAS  Google Scholar 

  40. Dallinger S et al (1998) Effects of acetazolamide on choroidal blood flow. Stroke 29:997–1001

    PubMed  CAS  Google Scholar 

  41. Dallinger S et al (2000) Endothelin-1 contributes to hyperoxia-induced vasoconstriction in the human retina. Invest Ophthalmol Vis Sci 41:864–869

    PubMed  CAS  Google Scholar 

  42. Dallinger S et al (2003) Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans. Am J Physiol Endocrinol Metab 284:1106–1111

    Google Scholar 

  43. Dawson TM et al (1991) Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 88:7797–7801

    PubMed  CAS  Google Scholar 

  44. de Juan JA et al (1995) Identification of endothelin receptor subtypes in rat retina using subtype-selective ligands. Brain Res 690:25–33

    PubMed  Google Scholar 

  45. Delles C et al (2004) Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke 35:1289–1293

    PubMed  CAS  Google Scholar 

  46. DeSantis L (2000) Preclinical overview of brinzolamide. Surv Ophthalmol 44(Suppl 2):S119–S129

    PubMed  Google Scholar 

  47. Deussen A et al (1993) L-arginine-derived nitric oxide: a major determinant of uveal blood flow. Exp Eye Res 57:129–134

    PubMed  CAS  Google Scholar 

  48. Dollery CT et al (1963) The response of normal retinal blood vessels to angiotensin and noradrenaline. J Physiol 165:500–507

    PubMed  CAS  Google Scholar 

  49. Donati G et al (1995) Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci 36:2228–2237

    PubMed  CAS  Google Scholar 

  50. Donati G et al (1997) Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion. Invest Ophthalmol Vis Sci 38:1450–1457

    PubMed  CAS  Google Scholar 

  51. Dorner GT et al (2003) Hyperglycemia affects flicker-induced vasodilation in the retina of healthy subjects. Vision Res 43:1495–1500

    PubMed  Google Scholar 

  52. Dorner GT et al (2003) Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol 285:H631–H636

    PubMed  CAS  Google Scholar 

  53. Dorner GT et al (2007) Effects of pentoxifylline and alprostadil on ocular hemodynamics in healthy humans. Invest Ophthalmol Vis Sci 48:815–819

    PubMed  Google Scholar 

  54. Eichhorn M, Lutjen-Drecoll E (1993) Distribution of endothelin-like immunoreactivity in the human ciliary epithelium. Curr Eye Res 12:753–757

    PubMed  CAS  Google Scholar 

  55. Evans DW et al (1999) Primary open-angle glaucoma patients characterized by ocular vasospasm demonstrate a different ocular vascular response to timolol versus betaxolol. J Ocul Pharmacol Ther 15:479–487

    PubMed  CAS  Google Scholar 

  56. Faingold D et al (2004) Assessment of retinal hemodynamics with the Canon laser blood flowmeter after a single dose of 2% dorzolamide hydrochloride eyedrops. Can J Ophthalmol 39:506–510

    PubMed  Google Scholar 

  57. Faraci FM et al (1989) Atherosclerosis potentiates constrictor responses of cerebral and ocular blood vessels to thromboxane in monkeys. Stroke 20:242–247

    PubMed  CAS  Google Scholar 

  58. Faraci FM et al (1991) Dietary treatment of atherosclerosis abolishes hyperresponsiveness of retinal blood vessels to serotonin in monkeys. Stroke 22:1405–1408

    PubMed  CAS  Google Scholar 

  59. Feke GT et al (1996) Retinal blood flow increases following short-term aspirin usage in type I diabetics with no or minimal retinopathy. Ophthalmic Res 28:108–116

    PubMed  CAS  Google Scholar 

  60. Fitzgerald ME et al (1996) Central neural circuits for the light-mediated reflexive control of choroidal blood flow in the pigeon eye: a laser Doppler study. Vis Neurosci 13:655–669

    PubMed  CAS  Google Scholar 

  61. Flugel C et al (1994) Species differences in choroidal vasodilative innervation: evidence for specific intrinsic nitrergic and VIP-positive neurons in the human eye. Invest Ophthalmol Vis Sci 35:592–599

    PubMed  CAS  Google Scholar 

  62. Foss RH (1955) Local application of diamox; an experimental study of its effect on the intraocular pressure. Am J Ophthalmol 39:336–337

    PubMed  CAS  Google Scholar 

  63. Fuchsjager-Mayrl G et al (2003) Role of endothelin-1 in choroidal blood flow regulation during isometric exercise in healthy humans. Invest Ophthalmol Vis Sci 44:728–733

    PubMed  Google Scholar 

  64. Fuchsjager-Mayrl G et al (2005) Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension. Br J Ophthalmol 89:1293–1297

    PubMed  CAS  Google Scholar 

  65. Fuchsjäger-Mayrl G et al (2001) Unilateral light–dark transitions affect choroidal blood flow in both eyes. Vision Res 41(22):2919–2924

    PubMed  Google Scholar 

  66. Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373–376

    PubMed  CAS  Google Scholar 

  67. Garhofer G et al (2005) Intravenous administration of L-arginine increases retinal and choroidal blood flow. Am J Ophthalmol 140:69–76

    PubMed  Google Scholar 

  68. Georgopoulos GT et al (2002) The short-term effect of latanoprost on intraocular pressure and pulsatile ocular blood flow. Acta Ophthalmol Scand 80:54–58

    PubMed  CAS  Google Scholar 

  69. Gherezghiher T et al (1991) Choroidal and ciliary body blood flow analysis: application of laser Doppler flowmetry in experimental animals. Exp Eye Res 53:151–156

    PubMed  CAS  Google Scholar 

  70. Goureau O et al (1993) Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation. Proc Natl Acad Sci USA 90:4276–4280

    PubMed  CAS  Google Scholar 

  71. Goureau O et al (1994) Human retinal pigmented epithelial cells produce nitric oxide in response to cytokines. Biochem Biophys Res Commun 198:120–126

    PubMed  CAS  Google Scholar 

  72. Grajewski AL et al (1991) Beta-adrenergic responsiveness of choroidal vasculature. Ophthalmology 98:989–995

    PubMed  CAS  Google Scholar 

  73. Granstam E, Granstam SO (1999) Regulation of uveal and retinal blood flow in STZ-diabetic and non-­diabetic rats; involvement of nitric oxide. Curr Eye Res 19:330–337

    PubMed  CAS  Google Scholar 

  74. Granstam E et al (1992) Ocular effects of ­endothelin-1 in the cat. Curr Eye Res 11:325–332

    PubMed  CAS  Google Scholar 

  75. Grant WM, Trotter RR (1954) Diamox (acetazoleamide) in treatment of glaucoma. AMA Arch Ophthalmol 51:735–739

    PubMed  CAS  Google Scholar 

  76. Green K et al (1985) Ocular blood flow after experimental alkali burns and prostaglandin administration. Arch Ophthalmol 103:569–571

    PubMed  CAS  Google Scholar 

  77. Grunwald JE (1990) Effect of timolol maleate on the retinal circulation of human eyes with ocular hypertension. Invest Ophthalmol Vis Sci 31:521–526

    PubMed  CAS  Google Scholar 

  78. Grunwald JE (1991) Effect of two weeks of timolol maleate treatment on the normal retinal circulation. Invest Ophthalmol Vis Sci 32:39–45

    PubMed  CAS  Google Scholar 

  79. Grunwald JE, Delehanty J (1992) Effect of topical carteolol on the normal human retinal circulation. Invest Ophthalmol Vis Sci 33:1853–1856

    PubMed  CAS  Google Scholar 

  80. Grunwald JE, Zinn H (1992) The acute effect of oral acetazolamide on macular blood flow. Invest Ophthalmol Vis Sci 33:504–507

    PubMed  CAS  Google Scholar 

  81. Grunwald JE et al (1997) Effect of chronic nitrate treatment on retinal vessel caliber in open-angle glaucoma. Am J Ophthalmol 123:753–758

    PubMed  CAS  Google Scholar 

  82. Grunwald JE et al (1997) Effects of dorzolamide hydrochloride 2% on the retinal circulation. Acta Ophthalmol Scand 75:236–238

    PubMed  CAS  Google Scholar 

  83. Haefliger IO et al (1992) Nitric oxide and endothelin-1 are important regulators of human ophthalmic artery. Invest Ophthalmol Vis Sci 33:2340–2343

    PubMed  CAS  Google Scholar 

  84. Haefliger IO et al (1993) Heterogeneity of endothelium-dependent regulation in ophthalmic and ciliary arteries. Invest Ophthalmol Vis Sci 34:1722–1730

    PubMed  CAS  Google Scholar 

  85. Haefliger IO et al (1994) Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest Ophthalmol Vis Sci 35:991–997

    PubMed  CAS  Google Scholar 

  86. Haefliger IO et al (1997) Effect of oxygen on relaxation of retinal pericytes by sodium nitroprusside. Graefes Arch Clin Exp Ophthalmol 235:388–392

    PubMed  CAS  Google Scholar 

  87. Haefliger IO et al (1999) Modulation of Heidelberg Retinal Flowmeter parameter flow at the papilla of healthy subjects: effect of carbogen, oxygen, high intraocular pressure, and beta-blockers. Surv Ophthalmol 43(Suppl 1):S59–S65

    PubMed  Google Scholar 

  88. Hardy P et al (1994) Free radicals in retinal and choroidal blood flow autoregulation in the piglet: interaction with prostaglandins. Invest Ophthalmol Vis Sci 35:580–591

    PubMed  CAS  Google Scholar 

  89. Hardy P et al (1996) Nitric oxide in retinal and choroidal blood flow autoregulation in newborn pigs: interactions with prostaglandins. Pediatr Res 39:487–493

    PubMed  CAS  Google Scholar 

  90. Hardy P et al (1998) A major role for prostacyclin in nitric oxide-induced ocular vasorelaxation in the piglet. Circ Res 83:721–729

    PubMed  CAS  Google Scholar 

  91. Hardy P et al (2000) Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy. Cardiovasc Res 47:489–509

    PubMed  CAS  Google Scholar 

  92. Harris A et al (1995) Acute effect of topical (beta-adrenergic antagonists on normal perimacular hemodynamics. J Glaucoma 4:36–40

    PubMed  CAS  Google Scholar 

  93. Harris A et al (1995) Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. Am J Ophthalmol 120:168–175

    PubMed  CAS  Google Scholar 

  94. Harris A et al (1996) Effects of topical dorzolamide on retinal and retrobulbar hemodynamics. Acta Ophthalmol Scand 74:569–572

    PubMed  CAS  Google Scholar 

  95. Harris A et al (1996) Acetazolamide and CO2: acute effects on cerebral and retrobulbar hemodynamics. J Glaucoma 5:39–45

    PubMed  CAS  Google Scholar 

  96. Harris A et al (1999) Dorzolamide, visual function and ocular hemodynamics in normal-tension glaucoma. J Ocul Pharmacol Ther 15:189–197

    PubMed  CAS  Google Scholar 

  97. Hashitani H et al (1998) Neuroeffector transmission in arterioles of the guinea-pig choroid. J Physiol 510(Pt 1):209–223

    PubMed  CAS  Google Scholar 

  98. Hata Y et al (2000) Retinal expression, regulation, and functional bioactivity of prostacyclin-­stimulating factor. J Clin Invest 106:541–550

    PubMed  CAS  Google Scholar 

  99. Haynes WG et al (1993) Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens 11:1375–1380

    PubMed  CAS  Google Scholar 

  100. Hayreh SS (1999) Retinal and optic nerve head ischemic disorders and atherosclerosis: role of serotonin. Prog Retin Eye Res 18:191–221

    PubMed  CAS  Google Scholar 

  101. Hayreh SS et al (1997) Serotonin-induced constriction of ocular arteries in atherosclerotic monkeys. Implications for ischemic disorders of the retina and optic nerve head. Arch Ophthalmol 115:220–228

    PubMed  CAS  Google Scholar 

  102. Hessemer V, Schmidt KG (1996) Effect of the vasodilator isosorbide dinitrate on ocular circulation. Klin Monbl Augenheilkd 208:188–195

    PubMed  CAS  Google Scholar 

  103. Huemer KH et al (2007) Role of nitric oxide in choroidal blood flow regulation during light/dark transitions. Invest Ophthalmol Vis Sci 48:4215–4219

    PubMed  Google Scholar 

  104. Iester M et al (2004) Retinal peripapillary blood flow before and after topical brinzolamide. Ophthalmolo­gica 218:390–396

    PubMed  CAS  Google Scholar 

  105. Ignarro LJ et al (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84:9265–9269

    PubMed  CAS  Google Scholar 

  106. Inan UU et al (2003) The effects of latanoprost and brimonidine on blood flow velocity of the retrobulbar vessels: a 3-month clinical trial. Acta Ophthalmol Scand 81:155–160

    PubMed  CAS  Google Scholar 

  107. Ingram CJ, Brubaker RF (1999) Effect of brinzolamide and dorzolamide on aqueous humor flow in human eyes. Am J Ophthalmol 128:292–296

    PubMed  CAS  Google Scholar 

  108. Ishii K et al (2001) Effects of topical latanoprost on optic nerve head circulation in rabbits, monkeys, and humans. Invest Ophthalmol Vis Sci 42:2957–2963

    PubMed  CAS  Google Scholar 

  109. Jacot JL et al (1998) Nitric oxide modulation of retinal, choroidal, and anterior uveal blood flow in newborn piglets. J Ocul Pharmacol Ther 14:473–489

    PubMed  CAS  Google Scholar 

  110. Jandrasits K et al (2002) Effect of noradrenaline on retinal blood flow in healthy subjects. Ophthalmology 109:291–295

    PubMed  Google Scholar 

  111. Januleviciene I et al (2004) A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients. Acta Ophthalmol Scand 82:730–737

    PubMed  CAS  Google Scholar 

  112. Jay WM et al (1984) Effect of topical epinephrine and timolol on ocular and optic nerve blood flow in phakic and aphakic rabbit eyes. Curr Eye Res 3:1199–1202

    PubMed  CAS  Google Scholar 

  113. Jonescu-Cuypers CP et al (2001) Effect of brimonidine tartrate on ocular hemodynamics in healthy ­volunteers. J Ocul Pharmacol Ther 17:199–205

    PubMed  CAS  Google Scholar 

  114. Kass MA, Holmberg NJ (1979) Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues. Invest Ophthalmol Vis Sci 18:166–171

    PubMed  CAS  Google Scholar 

  115. Kaup M et al (2004) Effects of brinzolamide on ocular haemodynamics in healthy volunteers. Br J Ophthalmol 88:257–262

    PubMed  CAS  Google Scholar 

  116. Kawamura H et al (2002) Endothelin-induced changes in the physiology of retinal pericytes. Invest Ophthalmol Vis Sci 43:882–888

    PubMed  Google Scholar 

  117. Kelly PA et al (1998) Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat. Br J Ophthalmol 82:1199–1202

    PubMed  CAS  Google Scholar 

  118. Kiel JW (1999) Modulation of choroidal autoregulation in the rabbit. Exp Eye Res 69:413–429

    PubMed  CAS  Google Scholar 

  119. Kiel JW (2000) Endothelin modulation of choroidal blood flow in the rabbit. Exp Eye Res 71:543–550

    PubMed  CAS  Google Scholar 

  120. Kiel JW, Patel P (1998) Effects of timolol and betaxolol on choroidal blood flow in the rabbit. Exp Eye Res 67:501–507

    PubMed  CAS  Google Scholar 

  121. Kimura I et al (2005) Effect of topical unoprostone isopropyl on optic nerve head circulation in controls and in normal-tension glaucoma patients. Jpn J Ophthalmol 49:287–293

    PubMed  CAS  Google Scholar 

  122. Kiss B et al (1999) Acetazolamide-induced cerebral and ocular vasodilation in humans is independent of nitric oxide. Am J Physiol 276:R1661–R1667

    PubMed  CAS  Google Scholar 

  123. Kitamura Y et al (1993) Nitric oxide-mediated retinal arteriolar and arterial dilatation induced by substance P. Invest Ophthalmol Vis Sci 34:2859–2865

    PubMed  CAS  Google Scholar 

  124. Kitanishi K et al (1997) Optic nerve head and choroidal circulation measured by laser Doppler flowmetry in response to intravenous administration of noradrenaline. Nippon Ganka Gakkai Zasshi 101:215–219

    PubMed  CAS  Google Scholar 

  125. Kitanishi K et al (2001) Liposomal prostaglandin E1 enhances optic nerve head blood flow in cats. J Ocul Pharmacol Ther 17:115–122

    PubMed  CAS  Google Scholar 

  126. Kitaya N et al (1997) Effect of timolol and UF-021 (a prostaglandin-related compound) on pulsatile ocular blood flow in normal volunteers. Ophthalmic Res 29:139–144

    PubMed  CAS  Google Scholar 

  127. Kobayashi M et al (2000) Nitric oxide synthase expression in ischemic rat retinas. Jpn J Ophthalmol 44:235–244

    PubMed  CAS  Google Scholar 

  128. Koistinaho J et al (1993) NADPH-diaphorase (nitric oxide synthase)-reactive amacrine cells of rabbit retina: putative target cells and stimulation by light. Neuroscience 57:587–597

    PubMed  CAS  Google Scholar 

  129. Kojima S et al (1997) Effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus evaluated with a laser speckle microcirculation analyser. Nippon Ganka Gakkai Zasshi 101:605–610

    PubMed  CAS  Google Scholar 

  130. Kondo M et al (1997) The role of nitric oxide in hyperaemic response to flicker in the retina and optic nerve in cats. Acta Ophthalmol Scand 75:232–235

    PubMed  CAS  Google Scholar 

  131. Koss MC (1994) Adrenoceptor mechanisms in epinephrine-induced anterior choroidal vasoconstriction in cats. Exp Eye Res 59:715–722

    PubMed  CAS  Google Scholar 

  132. Koss MC (1998) Role of nitric oxide in maintenance of basal anterior choroidal blood flow in rats. Invest Ophthalmol Vis Sci 39:559–564

    PubMed  CAS  Google Scholar 

  133. Koss MC (1999) Functional role of nitric oxide in regulation of ocular blood flow. Eur J Pharmacol 374:161–174

    PubMed  CAS  Google Scholar 

  134. Kothy P, Hollo G (2001) Does glaucoma medication influence the diameter of the retinal arteriole in the human eye? (A pilot study using the retinal vessel analyser). Acta Physiol Hung 88:281–292

    PubMed  CAS  Google Scholar 

  135. Koz OG et al (2007) Comparison of the effects of travoprost, latanoprost and bimatoprost on ocular circulation: a 6-month clinical trial. Acta Ophthalmol Scand 85:838–843

    PubMed  CAS  Google Scholar 

  136. Lamping KG et al (1989) Nonuniform vasomotor responses of the coronary microcirculation to serotonin and vasopressin. Circ Res 65:343–351

    PubMed  CAS  Google Scholar 

  137. Lepple-Wienhues A et al (1992) Endothelin-like immunoreactivity in the aqueous humour and in conditioned medium from cultured ciliary epithelial cells. Curr Eye Res 11:1041–1046

    PubMed  CAS  Google Scholar 

  138. Leung M, Grunwald JE (1997) Short-term effects of topical levobunolol on the human retinal circulation. Eye (Lond) 11(Pt 3):371–376

    Google Scholar 

  139. Liu CJ et al (2002) Effect of latanoprost 0.005% and brimonidine tartrate 0.2% on pulsatile ocular blood flow in normal tension glaucoma. Br J Ophthalmol 86:1236–1239

    PubMed  Google Scholar 

  140. Liu JH et al (2007) Resistance to blood flow in the rabbit ophthalmic artery after topical treatment with timolol. J Ocul Pharmacol Ther 23:103–109

    PubMed  Google Scholar 

  141. Lubeck P et al (2001) Effect of timolol on anterior optic nerve blood flow in patients with primary open-angle glaucoma as assessed by the Heidelberg retina flowmeter. J Glaucoma 10:13–17

    PubMed  CAS  Google Scholar 

  142. Luksch A et al (2000) Effect of systemic NO synthase inhibition on choroidal and optic nerve head blood flow in healthy subjects. Invest Ophthalmol Vis Sci 41:3080–3084

    PubMed  CAS  Google Scholar 

  143. Luksch A et al (2003) Role of NO in choroidal blood flow regulation during isometric exercise in healthy humans. Invest Ophthalmol Vis Sci 44:734–739

    PubMed  Google Scholar 

  144. Luksch A et al (2006) ETa-receptor blockade, but not ACE inhibition, blunts retinal vessel response during isometric exercise. Am J Physiol Heart Circ Physiol 290:H1693–H1698

    PubMed  CAS  Google Scholar 

  145. MacCumber MW, D’Anna SA (1994) Endothelin receptor-binding subtypes in the human retina and choroid. Arch Ophthalmol 112:1231–1235

    PubMed  CAS  Google Scholar 

  146. MacCumber MW et al (1991) Ocular effects of the endothelins. Abundant peptides in the eye. Arch Ophthalmol 109:705–709

    PubMed  CAS  Google Scholar 

  147. Makimoto Y et al (2002) Long-term effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus. Jpn J Ophthalmol 46:31–35

    PubMed  CAS  Google Scholar 

  148. Mann RM et al (1995) Nitric oxide and choroidal blood flow regulation. Invest Ophthalmol Vis Sci 36:925–930

    PubMed  CAS  Google Scholar 

  149. Martinez A, Sanchez-Salorio M (2009) A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5%, on retrobulbar hemodynamics and intraocular pressure in open-angle glaucoma patients. J Ocul Pharmacol Ther 25:239–248

    PubMed  CAS  Google Scholar 

  150. Martinez A et al (1999) Dorzolamide effect on ocular blood flow. Invest Ophthalmol Vis Sci 40:1270–1275

    PubMed  CAS  Google Scholar 

  151. Matsuo T, Cynader MS (1992) Localization of alpha-2 adrenergic receptors in the human eye. Ophthalmic Res 24:213–219

    PubMed  CAS  Google Scholar 

  152. Meyer P et al (1993) Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: role of nitric oxide and endothelins. Invest Ophthalmol Vis Sci 34:3614–3621

    PubMed  CAS  Google Scholar 

  153. Meyer P et al (1995) Effects of calcium channel blockers on the response to endothelin-1, bradykinin and sodium nitroprusside in porcine ciliary arteries. Exp Eye Res 60:505–510

    PubMed  CAS  Google Scholar 

  154. Meyer P et al (1996) Effect of dipyridamole on ­vascular responses of porcine ciliary arteries. Curr Eye Res 15:387–393

    PubMed  CAS  Google Scholar 

  155. Meyer P et al (1999) Localization of nitric oxide synthase isoforms in porcine ocular tissues. Curr Eye Res 18:375–380

    PubMed  CAS  Google Scholar 

  156. Michel MC et al (1995) Classification of alpha 1-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol 352:1–10

    PubMed  CAS  Google Scholar 

  157. Millar JC et al (1995) Drug effects on intraocular pressure and vascular flow in the bovine perfused eye using radiolabelled microspheres. J Ocul Pharmacol Ther 11:11–23

    PubMed  CAS  Google Scholar 

  158. Mittag TW, Tormay A (1985) Adrenergic receptor subtypes in rabbit iris-ciliary body membranes: classification by radioligand studies. Exp Eye Res 40:239–249

    PubMed  CAS  Google Scholar 

  159. Mori A et al (2007) Intravenously administered vasodilatory prostaglandins increase retinal and choroidal blood flow in rats. J Pharmacol Sci 103:103–112

    PubMed  CAS  Google Scholar 

  160. Mori A et al (2007) Stimulation of prostanoid IP and EP(2) receptors dilates retinal arterioles and increases retinal and choroidal blood flow in rats. Eur J Pharmacol 570:135–141

    PubMed  CAS  Google Scholar 

  161. Morsman CD et al (1995) The effect of topical beta-adrenoceptor blocking agents on pulsatile ocular blood flow. Eye (Lond) 9(Pt 3):344–347

    Google Scholar 

  162. Nagaoka T et al (2002) The effect of nitric oxide on retinal blood flow during hypoxia in cats. Invest Ophthalmol Vis Sci 43:3037–3044

    PubMed  Google Scholar 

  163. Nagel E et al (2005) Dorzolamide influences the autoregulation of major retinal vessels caused by artificial intraocular pressure elevation in patients with POAG: a clinical study. Curr Eye Res 30:129–137

    PubMed  CAS  Google Scholar 

  164. Narayan S et al (2003) Endothelin-1 synthesis and secretion in human retinal pigment epithelial cells (ARPE-19): differential regulation by cholinergics and TNF-alpha. Invest Ophthalmol Vis Sci 44:4885–4894

    PubMed  Google Scholar 

  165. Neufeld AH et al (1997) Nitric oxide synthase in the human glaucomatous optic nerve head. Arch Ophthalmol 115:497–503

    PubMed  CAS  Google Scholar 

  166. Nichols DE, Nichols CD (2008) Serotonin receptors. Chem Rev 108:1614–1641

    PubMed  CAS  Google Scholar 

  167. Nicolela MT et al (1996) A comparative study of the effects of timolol and latanoprost on blood flow velocity of the retrobulbar vessels. Am J Ophthalmol 122:784–789

    PubMed  CAS  Google Scholar 

  168. Nielsen PJ, Nyborg NC (1989) Calcium antagonist-induced relaxation of the prostaglandin-F2 alpha response of isolated calf retinal resistance arteries. Exp Eye Res 48:329–335

    PubMed  CAS  Google Scholar 

  169. Nilsson SF (2000) The significance of nitric oxide for parasympathetic vasodilation in the eye and other orbital tissues in the cat. Exp Eye Res 70:61–72

    PubMed  CAS  Google Scholar 

  170. Nishimura K et al (1996) Effects of endothelin-1 on optic nerve head blood flow in cats. J Ocul Pharmacol Ther 12:75–83

    PubMed  CAS  Google Scholar 

  171. Noergaard MH et al (2008) Indomethacin decreases optic nerve oxygen tension by a mechanism other than cyclo-oxygenase inhibition. Br J Ophthalmol 92:126–130

    PubMed  Google Scholar 

  172. Ohashi M et al (2007) Effects of topical travoprost and unoprostone on optic nerve head circulation in normal rabbits. Curr Eye Res 32:743–749

    PubMed  CAS  Google Scholar 

  173. Ohkubo H, Chiba S (1987) Pharmacological analysis of vasoconstriction of isolated canine ophthalmic and ciliary arteries to alpha-adrenoceptor agonists. Exp Eye Res 45:263–270

    PubMed  CAS  Google Scholar 

  174. Ohkubo H, Chiba S (1987) Responses of isolated canine ophthalmic and ciliary arteries to vasoactive substances. Jpn J Ophthalmol 31:627–634

    PubMed  CAS  Google Scholar 

  175. Okamura T et al (1997) Receptor subtypes involved in relaxation and contraction by arginine vasopressin in canine isolated short posterior ciliary arteries. J Vasc Res 34:464–472

    PubMed  CAS  Google Scholar 

  176. Oku H et al (1999) Experimental optic cup enlargement caused by endothelin-1-induced chronic optic nerve head ischemia. Surv Ophthalmol 44(Suppl 1):S74–S84

    PubMed  Google Scholar 

  177. Okuno T et al (2002) Evidence that nitric oxide is involved in autoregulation in optic nerve head of rabbits. Invest Ophthalmol Vis Sci 43:784–789

    PubMed  Google Scholar 

  178. Orgul S et al (1995) Optic nerve vasomotor effects of topical beta-adrenergic antagonists in rabbits. Am J Ophthalmol 120:441–447

    PubMed  CAS  Google Scholar 

  179. Orgul S et al (1996) An endothelin-1 induced model of optic nerve ischemia in the rabbit. Invest Ophthalmol Vis Sci 37:1860–1869

    PubMed  CAS  Google Scholar 

  180. Osborne NN (1993) Neuromediators and their receptors (adrenergic and endothelin types) in the eye. Therapie 48:549–558

    PubMed  CAS  Google Scholar 

  181. Osborne NN et al (1993) Endothelin receptors in the cornea, iris and ciliary processes. Evidence from binding, secondary messenger and PCR studies. Exp Eye Res 56:721–728

    PubMed  CAS  Google Scholar 

  182. Ostwald P et al (1995) Effect of nitric oxide synthase inhibition on blood flow after retinal ischemia in cats. Invest Ophthalmol Vis Sci 36:2396–2403

    PubMed  CAS  Google Scholar 

  183. Ostwald P et al (1997) Adenosine receptor blockade and nitric oxide synthase inhibition in the retina: impact upon post-ischemic hyperemia and the electroretinogram. Vision Res 37:3453–3461

    PubMed  CAS  Google Scholar 

  184. Palmer RM et al (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526

    PubMed  CAS  Google Scholar 

  185. Palmer RM et al (1988) L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153:1251–1256

    PubMed  CAS  Google Scholar 

  186. Parys-Van Ginderdeuren R et al (1992) Dissociation between prostaglandin levels and blood flow to the retina and choroid in the newborn pig after nonsteroidal antiinflammatory drugs. Invest Ophthalmol Vis Sci 33:3378–3384

    PubMed  CAS  Google Scholar 

  187. Pedersen DB et al (2004) Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing. Br J Ophthalmol 88:1088–1091

    PubMed  CAS  Google Scholar 

  188. Pfeiffer N (1997) Dorzolamide: development and clinical application of a topical carbonic anhydrase inhibitor. Surv Ophthalmol 42:137–151

    PubMed  CAS  Google Scholar 

  189. Pillunat LE et al (1999) Effect of topical dorzolamide on optic nerve head blood flow. Graefes Arch Clin Exp Ophthalmol 237:495–500

    PubMed  CAS  Google Scholar 

  190. Polak K et al (2000) Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol 84:1285–1290

    PubMed  CAS  Google Scholar 

  191. Polak K et al (2001) Effect of endothelin and BQ123 on ocular blood flow parameters in healthy subjects. Invest Ophthalmol Vis Sci 42:2949–2956

    PubMed  CAS  Google Scholar 

  192. Polak K et al (2003) Regulation of human retinal blood flow by endothelin-1. Exp Eye Res 76:633–640

    PubMed  CAS  Google Scholar 

  193. Polak K et al (2007) Altered nitric oxide system in patients with open-angle glaucoma. Arch Ophthalmol 125:494–498

    PubMed  CAS  Google Scholar 

  194. Polska E et al (2002) Partial antagonism of endothelin 1-induced vasoconstriction in the human choroid by topical unoprostone isopropyl. Arch Ophthalmol 120:348–352

    PubMed  CAS  Google Scholar 

  195. Pournaras C et al (1978) Studies on the role of prostaglandins in the regulation of retinal blood flow. Exp Eye Res 26:687–697

    PubMed  CAS  Google Scholar 

  196. Prasanna G et al (1998) Regulation of endothelin-1 in human non-pigmented ciliary epithelial cells by tumor necrosis factor-alpha. Exp Eye Res 66:9–18

    PubMed  CAS  Google Scholar 

  197. Ramachandran E et al (1993) Effects of endothelin on cultured bovine retinal microvascular pericytes. Invest Ophthalmol Vis Sci 34:586–595

    PubMed  CAS  Google Scholar 

  198. Rapoport RM et al (1983) Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 306:174–176

    PubMed  CAS  Google Scholar 

  199. Rassam SM et al (1993) The effect of acetazolamide on the retinal circulation. Eye (Lond) 7(Pt 5):697–702

    Google Scholar 

  200. Rubanyi GM, Polokoff MA (1994) Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 46:325–415

    PubMed  CAS  Google Scholar 

  201. Sampaolesi J et al (2001) Antiglaucomatous drugs effects on optic nerve head flow: design, baseline and preliminary report. Int Ophthalmol 23:359–367

    PubMed  CAS  Google Scholar 

  202. Sato T et al (2001) Short-term effect of beta-adrenoreceptor blocking agents on ocular blood flow. Curr Eye Res 23:298–306

    PubMed  Google Scholar 

  203. Sato E et al (2003) Role of nitric oxide in regulation of retinal blood flow during hypercapnia in cats. Invest Ophthalmol Vis Sci 44:4947–4953

    PubMed  Google Scholar 

  204. Schmetterer L, Polak K (2001) Role of nitric oxide in the control of ocular blood flow. Prog Retin Eye Res 20:823–847

    PubMed  CAS  Google Scholar 

  205. Schmetterer L et al (1997) Nitric oxide and ocular blood flow in patients with IDDM. Diabetes 46:653–658

    PubMed  CAS  Google Scholar 

  206. Schmetterer L et al (1997) Role of NO in the O2 and CO2 responsiveness of cerebral and ocular circulation in humans. Am J Physiol 273:R2005–R2012

    PubMed  CAS  Google Scholar 

  207. Schmetterer L et al (1997) Effects of endothelin-1 (ET-1) on ocular hemodynamics. Curr Eye Res 16:687–692

    PubMed  CAS  Google Scholar 

  208. Schmetterer L et al (1997) The effect of systemic nitric oxide-synthase inhibition on ocular fundus pulsations in man. Exp Eye Res 64:305–312

    PubMed  CAS  Google Scholar 

  209. Schmetterer L et al (1997) Effects of antiglaucoma drugs on ocular hemodynamics in healthy volunteers. Clin Pharmacol Ther 61:583–595

    PubMed  CAS  Google Scholar 

  210. Schmidt KG et al (1998) Topical carbonic anhydrase inhibition increases ocular pulse amplitude in high tension primary open angle glaucoma. Br J Ophthalmol 82:758–762

    PubMed  CAS  Google Scholar 

  211. Seligsohn EE, Bill A (1993) Effects of NG-nitro-L-arginine methyl ester on the cardiovascular system of the anaesthetized rabbit and on the cardiovascular response to thyrotropin-releasing hormone. Br J Pharmacol 109:1219–1225

    PubMed  CAS  Google Scholar 

  212. Seong GJ et al (1999) Effects of 0.005% latanoprost on optic nerve head and peripapillary retinal blood flow. Ophthalmologica 213:355–359

    PubMed  CAS  Google Scholar 

  213. Siesky B et al (2008) A comparative study of the effects of brinzolamide and dorzolamide on retinal oxygen saturation and ocular microcirculation in patients with primary open-angle glaucoma. Br J Ophthalmol 92:500–504

    PubMed  CAS  Google Scholar 

  214. Siesky B et al (2009) Literature review and meta-analysis of topical carbonic anhydrase inhibitors and ocular blood flow. Surv Ophthalmol 54:33–46

    PubMed  Google Scholar 

  215. Silver LH (2000) Dose–response evaluation of the ocular hypotensive effect of brinzolamide ophthalmic suspension (Azopt). Brinzolamide Dose–response Study Group. Surv Ophthalmol 44(Suppl 2):S147–S153

    PubMed  Google Scholar 

  216. Simsek T et al (2006) Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma. J Ocul Pharmacol Ther 22:79–85

    PubMed  CAS  Google Scholar 

  217. Spada CS et al (2002) Vascular activities of prostaglandins and selective prostanoid receptor agonists in human retinal microvessels. Exp Eye Res 75:155–163

    PubMed  CAS  Google Scholar 

  218. Sponsel WE et al (2002) Comparative effects of latanoprost (Xalatan) and unoprostone (Rescula) in patients with open-angle glaucoma and suspected glaucoma. Am J Ophthalmol 134:552–559

    PubMed  CAS  Google Scholar 

  219. Steigerwalt RD Jr et al (2001) Ocular and orbital blood flow velocity in patients with peripheral vascular disease and diabetes treated with intravenous prostaglandin E1. J Ocul Pharmacol Ther 17:529–535

    PubMed  CAS  Google Scholar 

  220. Steigerwalt RD Jr et al (2001) Ocular and retrobulbar blood flow in ocular hypertensives treated with topical timolol, betaxolol and carteolol. J Ocul Pharmacol Ther 17:537–544

    PubMed  CAS  Google Scholar 

  221. Stjernschantz J et al (1989) Vasodynamic and angiogenic effects of eicosanoids in the eye. Prog Clin Biol Res 312:155–170

    PubMed  CAS  Google Scholar 

  222. Stjernschantz J et al (1999) Effect of latanoprost on regional blood flow and capillary permeability in the monkey eye. Arch Ophthalmol 117:1363–1367

    PubMed  CAS  Google Scholar 

  223. Stjernschantz J et al (2000) Microvascular effects of selective prostaglandin analogues in the eye with special reference to latanoprost and glaucoma treatment. Prog Retin Eye Res 19:459–496

    PubMed  CAS  Google Scholar 

  224. Strenn K et al (1998) Reversal of endothelin-1-induced ocular hemodynamic effects by low-dose nifedipine in humans. Clin Pharmacol Ther 63:54–63

    PubMed  CAS  Google Scholar 

  225. Su EN et al (1994) Adrenergic and nitrergic neurotransmitters are released by the autonomic system of the pig long posterior ciliary artery. Curr Eye Res 13:907–917

    PubMed  CAS  Google Scholar 

  226. Su EN et al (1994) Effects of extracellular pH on ­agonist-induced vascular tone of the cat ophthalmociliary artery. Invest Ophthalmol Vis Sci 35:998–1007

    PubMed  CAS  Google Scholar 

  227. Su EN et al (1995) Altered vasoactivity in the early diabetic eye: measured in the isolated perfused rat eye. Exp Eye Res 61:699–711

    PubMed  CAS  Google Scholar 

  228. Sugiyama T, Azuma I (1995) Effect of UF-021 on optic nerve head circulation in rabbits. Jpn J Ophthalmol 39:124–129

    PubMed  CAS  Google Scholar 

  229. Sugiyama T et al (1993) Effect of endothelin-1 on ocular circulation. Nippon Ganka Gakkai Zasshi 97:678–682

    PubMed  CAS  Google Scholar 

  230. Sugiyama K et al (1996) The effects of intravitreally injected endothelin-1 on the iris-ciliary body microvasculature in rabbits. Curr Eye Res 15:633–637

    PubMed  CAS  Google Scholar 

  231. Sugiyama T et al (1998) The effect of continuous and intravenous application of carteolol chloride on tissue blood flow in the rabbit optic nerve head. Nippon Ganka Gakkai Zasshi 102:662–666

    PubMed  CAS  Google Scholar 

  232. Sugiyama T et al (2000) Effect of nitric oxide synthase inhibitor on optic nerve head circulation in conscious rabbits. Invest Ophthalmol Vis Sci 41:1149–1152

    PubMed  CAS  Google Scholar 

  233. Takagi C et al (1996) Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. Invest Ophthalmol Vis Sci 37:2099–2109

    PubMed  CAS  Google Scholar 

  234. Takahashi K et al (1989) Production of endothelin 1 by cultured bovine retinal endothelial cells and ­presence of endothelin receptors on associated pericytes. Diabetes 38:1200–1202

    PubMed  CAS  Google Scholar 

  235. Tamaki Y et al (1999) Effect of topical betaxolol on tissue circulation in the human optic nerve head. J Ocul Pharmacol Ther 15:313–321

    PubMed  CAS  Google Scholar 

  236. Tamaki Y et al (2001) Effect of topical unoprostone on circulation of human optic nerve head and retina. J Ocul Pharmacol Ther 17:517–527

    PubMed  CAS  Google Scholar 

  237. Thorig L, Bill A (1986) Effects of B-HT 920 in the eye and on regional blood flows in anaesthetized and conscious rabbits. Curr Eye Res 5:565–573

    PubMed  CAS  Google Scholar 

  238. Tilton RG et al (1999) Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Invest Ophthalmol Vis Sci 40:689–696

    PubMed  CAS  Google Scholar 

  239. Toda N et al (1995) Functional role of nerve-derived nitric oxide in isolated dog ophthalmic arteries. Invest Ophthalmol Vis Sci 36:563–570

    PubMed  CAS  Google Scholar 

  240. Toda N et al (1995) Mechanisms underlying endothelium-independent relaxation by acetylcholine in canine retinal and cerebral arteries. J Pharmacol Exp Ther 274:1507–1512

    PubMed  CAS  Google Scholar 

  241. Toda M et al (1998) Desmopressin-induced dog ­ciliary artery relaxation. Eur J Pharmacol 344:197–201

    PubMed  CAS  Google Scholar 

  242. Tomidokoro A et al (1998) In vivo measurement of iridial circulation using laser speckle phenomenon. Invest Ophthalmol Vis Sci 39:364–371

    PubMed  CAS  Google Scholar 

  243. Tomidokoro A et al (1999) Effects of topical carteolol and timolol on tissue circulation in the iris and choroid. Curr Eye Res 18:381–390

    PubMed  CAS  Google Scholar 

  244. Toriu N et al (2001) Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits. J Ocul Pharmacol Ther 17:131–149

    PubMed  CAS  Google Scholar 

  245. Trew DR, Smith SE (1991) Postural studies in ­pulsatile ocular blood flow: II. Chronic open angle glaucoma. Br J Ophthalmol 75:71–75

    PubMed  CAS  Google Scholar 

  246. Vallance P et al (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2:997–1000

    PubMed  CAS  Google Scholar 

  247. Van Buskirk EM et al (1990) Ciliary vasoconstriction after topical adrenergic drugs. Am J Ophthalmol 109:511–517

    PubMed  Google Scholar 

  248. Wang Y et al (1993) Mechanisms of acetylcholine-induced relaxation in dog external and internal ­ophthalmic arteries. Exp Eye Res 57:275–281

    PubMed  CAS  Google Scholar 

  249. Watanabe K, Chiou GC (1983) Action mechanism of timolol to lower the intraocular pressure in rabbits. Ophthalmic Res 15:160–167

    PubMed  CAS  Google Scholar 

  250. Weigert G et al (2007) Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting. Invest Ophthalmol Vis Sci 48:4220–4225

    PubMed  Google Scholar 

  251. Weigert G et al (2007) Intravenous administration of clonidine reduces intraocular pressure and alters ocular blood flow. Br J Ophthalmol 91:1354–1358

    PubMed  Google Scholar 

  252. Weigert G et al (2008) Effect of unspecific inhibition of cyclooxygenase by indomethacin on retinal and choroidal blood flow. Invest Ophthalmol Vis Sci 49:1065–1070

    PubMed  Google Scholar 

  253. Wiencke AK et al (1994) Nonadrenergic noncholinergic vasodilation in bovine ciliary artery involves CGRP and neurogenic nitric oxide. Invest Ophthalmol Vis Sci 35:3268–3277

    PubMed  CAS  Google Scholar 

  254. Wikberg-Matsson A et al (1996) Characterization of alpha 2-adrenoceptor subtypes in the porcine eye: identification of alpha 2A-adrenoceptors in the choroid, ciliary body and iris, and alpha 2A- and alpha 2C-adrenoceptors in the retina. Exp Eye Res 63:57–66

    PubMed  CAS  Google Scholar 

  255. Wikberg-Matsson A et al (2000) Characterization of alpha(1)-adrenoceptor subtypes in the eye. Exp Eye Res 70:51–60

    PubMed  CAS  Google Scholar 

  256. Yamamoto R et al (1993) The localization of nitric oxide synthase in the rat eye and related cranial ­ganglia. Neuroscience 54:189–200

    PubMed  CAS  Google Scholar 

  257. Yamazaki S, Baba H (1993) Acute effect of topical carteolol on ocular pulsatile volume change. Acta Ophthalmol (Copenh) 71:760–764

    CAS  Google Scholar 

  258. Yan HY, Chiou GC (1987) Effects of L-timolol, D-timolol, haloperidol and domperidone on rabbit retinal blood flow measured with laser Doppler method. Ophthalmic Res 19:45–48

    PubMed  CAS  Google Scholar 

  259. Yanagisawa M et al (1988) A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels. J Hypertens Suppl 6:S188–S191

    PubMed  CAS  Google Scholar 

  260. Yao K et al (1991) Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery. Invest Ophthalmol Vis Sci 32:1791–1798

    PubMed  CAS  Google Scholar 

  261. Yorio T et al (2002) Endothelin: is it a contributor to glaucoma pathophysiology? J Glaucoma 11:259–270

    PubMed  Google Scholar 

  262. Yoshida A et al (1991) Effect of timolol on human retinal, choroidal and optic nerve head circulation. Ophthalmic Res 23:162–170

    PubMed  CAS  Google Scholar 

  263. Zagvazdin YS et al (1996) Neural nitric oxide mediates Edinger-Westphal nucleus evoked increase in choroidal blood flow in the pigeon. Invest Ophthalmol Vis Sci 37:666–672

    PubMed  CAS  Google Scholar 

  264. Zeitz O et al (2005) Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428]. BMC Ophthalmol 5:6

    PubMed  Google Scholar 

  265. Zeitz O et al (2006) Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients? Eye (Lond) 20:668–673

    CAS  Google Scholar 

  266. Zhu P et al (1997) Relaxation by bradykinin in porcine ciliary artery. Role of nitric oxide and K(+)-channels. Invest Ophthalmol Vis Sci 38:1761–1767

    PubMed  CAS  Google Scholar 

  267. Zhu Y et al (1998) Mechanisms of hyperoxia-induced reductions in retinal blood flow in newborn pig. Exp Eye Res 67:357–369

    PubMed  CAS  Google Scholar 

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  1. Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria

    Gerhard Garhöfer M.D.

  2. Department of Clinical Pharmacology, Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria

    Leopold Schmetterer Ph.D.

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    Leopold Schmetterer

  2. Health Science Center, Deptartment of Ophthalmology, University of Texas, Floyd Curl Drive 7703, San Antonio, 78229-3900, Texas, USA

    Jeffrey Kiel

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Garhöfer, G., Ph.D., L.S. (2012). Endothelial and Adrenergic Control. In: Schmetterer, L., Kiel, J. (eds) Ocular Blood Flow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69469-4_13

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