Abstract
Delivery of nicotine in the most desirable form is critical in maintaining people's use of tobacco products. Interpretation of results by tobacco industry scientists, studies that measure free-base nicotine directly in tobacco smoke, and the variability of free-base nicotine in smokeless tobacco products all indicate that the form of nicotine delivered to the tobacco user, in addition to the total amount, is an important factor in whether people continue to use the product following their initial exposure. The physiological impact of nicotine varies with the fraction that is in the free-base form and this leads to continued exposure to other toxic tobacco contents and emissions. In addition to evaluating the total nicotine delivered to the user, measuring the fraction of nicotine in the free-base form is critical in understanding and controlling the influence of nicotine on tobacco use.
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References
Anonymous (1980) Key issues. Available from: http://tobaccodocuments.org/productdesign/511367302-7326.html. Accessed 2 April 2007
Anonymous (1985) Technology: ammoniation. Available from: http://legacy.library.ucsf.edu/tid/kik83d00/pdf. Accessed 20 Dec 2007
Anonymous (1994) The effects of cigarette smoke “pH” on nicotine delivery and subjective evaluations. Available from: http://legacy.library.ucsf.edu/cgi/getdoc?tid=snz74e00&fmt=pdf&ref=results. Accessed 24 Nov 2004
Armitage AK, Turner DM (1970) Absorption of nicotine in cigarette and cigar smoke through the oral mucosa. Nature 226:1231–1233
Ayo-Yusuf OA, Swart TJP, Pickworth WB (2004) Nicotine delivery capabilities of smokeless tobacco products and implications for control of tobacco dependence in South Africa. Tobacco Control 13:186–189
Backhurst JD (1965) A relation between the “strength” of a cigarette and the “extractable nicotine” in the smoke. Available from: http://ltdlimages.library.ucsf.edu/imagesg/g/u/m/gum51f00/Sgum51f00.pdf. Accessed 1 Aug 2007
Blevins RA Jr (1973) Letter to Mr. W.S. Smith, Jr. Available from: http://ltdlimages.library.ucsf.edu/imagese/e/b/n/ebn49d00/Sebn49d00.pdf. Accessed 18 July 2007
Borgerding M, Klus KJ (2005) Analysis of complex mixtures – cigarette smoke. Exp Toxicol Pathol 57:43–73
CDC (Centers for Disease Control and Prevention) (1999a) Annual submission of the quantity of nicotine contained in smokeless tobacco products manufactured, imported, or packaged in the United States requirement; notice. Federal Register 64:14086–14096
CDC (Centers for Disease Control and Prevention) (1999b) Determination of nicotine, pH, and moisture content of six commercial moist snuff products – Florida, January–February 1999. Morb Mortal Wkly Rep 48:398–401
Chen L (1976) pH of smoke: a review. Available from: http://ltdlimages.library.ucsf.edu/imagesp/p/h/i/phi98c00/Sphi98c00.pdf. Accessed 17 July 2007
Christopher FH Jr (1973) Correlation of pH with share performance. Available from: http://legacy.library.ucsf.edu/tid/fbn49d00/pdf. Accessed on 20 Dec 2007
Creighton DE (1988) The significance of pH in tobacco and tobacco smoke. Available from: http://ltdlimages.library.ucsf.edu/imagest/t/r/h/trh97c00/Strh97c00.pdf. Accessed 1 Aug 2007
Crellin RA (1985) Project SHIP (Examination of branded and experimental products from the USA) Report no. RD.2027-C Restricted. Available from: http://legacy.library.ucsf.edu/tid/gue51f00/pdf. Accessed 20 Dec 2007
Dickerson JP (1977) Historical trends in “tar”, nicotine and smoke pH for Winston and Marlboro. Available from: http://tobaccodocuments.org/rjr/509308839-8849.html. Accessed 2 April 2007
Djordjevic MV, Hoffmann D, Glynn T, Connolly GN (1995) US commercial brands of moist snuff, 1994. I. Assessment of nicotine, moisture, and pH. Tobacco Control 4:62–66
Evelyn SR (1967) The transfer of nicotine from smoke into blood using a perfused canine lung. Report. British American Tobacco Co. Available from: http://legacy.library.ucsf.edu/tid/zed72d00/pdf. Accessed 20 Dec 2007
Fant RV, Henningfield JE, Nelson RA, Pickworth WB (1999) Pharmacokinetics and pharmacody-namics of moist snuff in humans. Tobacco Control 8:387–392
Gordon DL (1992) PM's global strategy: Marlboro product technology. Available from: http://ltdlimages.library.ucsf.edu/imagesu/u/f/t/uft21f00/Suft21f00.pdf. Accessed 31 July 2007
Gregory CF (1980) Observation of free nicotine changes in tobacco smoke/#528. Available from: http://ltdlimages.library.ucsf.edu/imagesz/z/d/s/zds24f00/Szds24f00.pdf. Accessed 23 July 2007
Gullotta FP, Hayes CS, Martin BR (1990) The electrophysiological and subjective consequences of tobacco filler pH modifications: a proposal. Available from: http://ltdlimages.library.ucsf.edu/imagesx/x/x/x/xxx74e00/Sxxx74e00.pdf. Accessed 23 July 2007
Henningfield JE, Keenan RM (1993) Nicotine delivery kinetics and abuse liability. J Consult Clin Psychol 61:743–750
Henningfield JE, Radzius A, Cone EJ (1995) Estimation of available nicotine content of six smokeless tobacco products. Tobacco Control 4:57–61
Henningfield JE, Fant RV, Tomar SL (1997) Smokeless tobacco: An addicting drug. Adv Dent Res 11:330–335
Henningfield JE, Pankow JF, Garrett BE (2003) Ammonia and other chemical base tobacco additives and cigarette nicotine delivery: issues and research needs. Nicotine Tobacco Res 6:199–205
Hinds W, First MW, Huber GL, Shea JW (1983) A method for measuring the deposition of cigarette smoke during smoking. Am Ind Hyg Assoc J 44:113–118
Ingebrethsen BJ (2006) Numerical simulation of the effects of dilution level, depth of inhalation, and smoke composition on nicotine vapor phase deposition during cigarette smoking. Inhal Toxicol 18:1071–1076
Ingebrethsen BJ, Lyman CS, Coleman WM III, Nelson PR (1991) Smoke nicotine “volatility” measurement methods. Available from: http://ltdlimages.library.ucsf.edu/imagest/t/n/y/tny93d00/Stny93d00.pdf. Accessed 19 July 2007
Ingebrethsen BJ, Lyman C, Risner CH, Partom P, Gordon BM (2001) Particle-gas equilibria of ammonia and nicotine in mainstream cigarette smoke. Aerosol Sci Technol 35:874–886
Larson TM, Morgan JP (1976) Application of free nicotine to cigarette tobacco and the delivery of that nicotine in the cigarette smoke. Available from: http://ltdlimages.library.ucsf.edu/imagesx/x/f/o/xfo99d00/Sxfo99d00.pdf. Accessed 3 Aug 2007
Lewis DA, Colbeck I, Mariner DC (1995) Diffusion of mainstream tobacco smoke and its effect upon the evaporation and diffusion of nicotine. J Aerosol Sci 26:841–846
Liang C, Pankow JF (1996) Gas/particle partitioning of organic compounds to environmental tobacco smoke: partition coefficient measurements by desorption and comparison to urban par-ticulate material. Environ Sci Technol 30:2800–2805
Lin OC, Honeycutt RH (1984) Chemical characterization of US cigarette brands. Available from: http://legacy.library.ucsf.edu/cgi/getdoc?tid=ejj23f00&fmt=pdf&ref=results. Accessed 2 April 2007
Maynor HW, Rosene CJ (1981) A comparison of the extractable nicotine content of smoke from Barclay and Cambridge cigarettes. Available from: http://ltdlimages.library.ucsf.edu/imagesk/k/q/s/kqs40f00/Skqs40f00.pdf. Accessed 19 July 2007
Minnemeyer HJ (1976) Research proposal – Development of assay for free nicotine. Available from: http://ltdlimages.library.ucsf.edu/imagesv/v/d/t/vdt13c00/Svdt13c00.pdf. Accessed 23 July 2007
Mosser LO (1984) Effects of varying smoke pH on Kool KS/244. Available from: http://ltdlimages.library.ucsf.edu/imagess/s/y/d/syd60f00/Ssyd60f00.pdf. Accessed 20 July 2007
Pankow JF (2001) A consideration of the role of gas/particle partitioning in the deposition of nicotine and other tobacco smoke compounds in the respiratory tract. Chem Res Toxicol 14:1465–1481
Pankow JF, Mader BT, Isabelle LM, Luo W, Pavlick A, Liang C (1997) Conversion of nicotine in tobacco smoke to its volatile and available unprotonated form through the action of gaseous ammonia. Environ Sci Technol 31:2428–2433
Pankow JF, Tavakoli AD, Lu W, Isabelle LM (2003) Percent free base nicotine in the tobacco smoke particulate matter of selected commercial and reference cigarettes. Chem Res Toxicol 16:1014–1018
Piehl DH (1973) Basic study – smoke balance and control. Available from: http://tobaccodocuments.org/productdesign/500997469-7475.html. Accessed 2 April 2007
Reininghaus W (1994) Bioavailability of nicotine. Available from: http://ltdlimages.library.ucsf.edu/imagesd/d/e/a/dea84e00/Sdea84e00.pdf. Accessed 3 Aug 2007
Renner CC, Enoch C, Patten CA, Ebbert JO, Hurt RD, Moyer TP, Provost EM (2005) Iqmik: a form of smokeless tobacco used among Alaska natives. Am J Health Behav 29:588–594
Richter P, Spierto FW (2003) Surveillance of smokeless tobacco nicotine, pH, moisture, and un-protonated nicotine content. Nicotine Tobacco Res 5:885–889
Schievelbein H, Eberhardt R, Loschenkohl K, Rahlfs V, Bedall FK (1973) Absorption of nicotine through the oral mucosa: I. Measurement on nicotine concentration in the blood after application of nicotine and total particulate matter. Agents Actions 3/4:254–258
Schori TR (1979) Free nicotine: Its implications on smoke impact. Available from: http://ltdlimages.library.ucsf.edu/imagesm/m/z/h/mzh24f00/Smzh24f00.pdf. Accessed 18 July 2007
Seeman JI, Fournier JA, Paine JB, Waymack BE (1999) The form of nicotine in tobacco. Thermal transfer of nicotine and nicotine acid salts to nicotine in the gas phase. J Agric Food Chem 47:5133–5145
Teague CE (1973) Implications and activities arising from correlation of smoke pH with nicotine impact, other smoke qualities, and cigarette sales. Available from: http://legacy.library.ucsf.edu/cgi/getdoc?tid=fcb59d00&fmt=pdf&ref=results. Accessed 12 July 2005
Tomar SL, Giovino GA, Eriksen MP (1995) Smokeless tobacco brand preference and brand switching and U.S. adolescents and young adults. Tobacco Control 4:67–72
Watson DC (1991) Gas phase nicotine – status. Available from: http://ltdlimages.library.ucsf.edu/imagesm/m/r/i/mri24e00/Smri24e00.pdf. Accessed 19 July 2007
Watson CH, Trommel JS, Ashley DL (2004) A solid-phase microextraction-based approach to determine free-base nicotine in trapped mainstream cigarette smoke total particulate matter. J Agric Food Chem 352:7240–7245
Wayne GF, Connolly GN, Henningfield JE (2006) Brand differences of free-base nicotine delivery in cigarette smoke: the view of the tobacco industry document. Tobacco Control 15:189–198
Wilbert J (1987) Tobacco and shamanism in South America. Yale University Press, New Haven, Connecticut, p 294
Wilson JB (1970) Adjustment in the smoke pH of Winston cigarettes. Available from: http://ltdlimages.library.ucsf.edu/imagesm/m/e/z/mez65d00/Smez65d00.pdf. Accessed 17 July 2007
Zhang Z, Pawliszyn J (1993) Headspace solid phase microextraction. Anal Chem 65:1843–1852
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Ashley, D.L., Pankow, J.F., Tavakoli, A.D., Watson, C.H. (2009). Approaches, Challenges, and Experience in Assessing Free Nicotine. In: Henningfield, J.E., London, E.D., Pogun, S. (eds) Nicotine Psychopharmacology. Handbook of Experimental Pharmacology, vol 192. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69248-5_15
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DOI: https://doi.org/10.1007/978-3-540-69248-5_15
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