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References
Kredich, N.M.; Becker, M.A.: Cysteine biosynthesis: serine transacetylase and O-acetylserine sulfhydrylase. Methods Enzymol., 17 B, 459–470 (1971)
Thompson, J.F.; Moore, D.P.: Enzymatic synthesis of cysteine and S-methylcysteine in plant extracts. Biochem. Biophys. Res. Commun., 31, 281–287 (1968)
Becker, M.A.; Kredich, N.M.; Tomkins, G.M.: The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium. J. Biol. Chem., 244, 2418–2427 (1969)
Yamagata, S.; Takeshima, K.; Naiki, N.: Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast. J. Biochem., 75, 1221–1229 (1974)
Tamura, G.; Iwasawa, T.; Masada, M.; Fukushima, K.: Some properties of cysteine synthase from radish roots. Agric. Biol. Chem., 40, 637–638 (1976)
Yamagata, S.; Takeshima, K.: O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Further purification and characterization as a pyridoxal enzyme. J. Biochem., 80, 777–785 (1976)
Yamagata, S.: O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Subunit structure. J. Biochem., 80, 787–797 (1976)
Burnell, J.N.; Whatley, F.R.: Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of serine transacetylase, O-acetylserine sulphydrylase and β-cystathionase. Biochim. Biophys. Acta, 481, 246–265 (1977)
Ascano, A.; Nicholas, D.J.D.: Purification and properties of O-acetyl-l-serine sulphhydrolase from wheat leaves. Phytochemistry, 16, 889–893 (1977)
Hock Ng, B.; Anderson, J.W.: Chloroplast cysteine synthases of Trifolium repens and Pisum sativum. Biochemistry, 17, 879–885 (1978)
Cook, P.F.; Wedding, R.T.: Cysteine synthetase from Salmonella typhimurium LT-2. Aggregation, kinetic behavior, and effect of modifiers. J. Biol. Chem., 253, 7874–7879 (1978)
Fankhauser, H.; Brunold, C.: Localization of O-acetyl-l-serine sulphydrylase in Spinacia oleracea L. Plant Sci. Lett., 14, 185–192 (1979)
Yamagata, S.: Occurrence of low molecular weight O-acetylserine sulfhydrylase in the yeast Saccharomyces cerevisiae. J. Biochem., 88, 1419–1423 (1980)
Diessner, W.; Schmidt, A.: Isoenzymes of cysteine synthase in the cyanobacterium Synechococcus 6301. Z. Pflanzenphysiol., 102, 57–68 (1981)
Yamagata, S.: Low-molecular-weight O-acetylserine sulfhydrylase and serine sulfhydrylase of Saccharomyces cerevisiae are the same protein. J. Bacteriol., 147, 688–690 (1981)
Hensel, G.; Trueper, H.G.: O-acetylserine sulfhydrylase and S-sulfocysteine synthase activities of Chromatium vinosum. Arch. Microbiol., 130, 228–233 (1981)
Yanase, H.; Sakai, T.; Tonumura, K.: Purification and crystallization of a β-cyanoalanine-forming enzyme from Enterobacter sp. 10-1. Agric. Biol. Chem., 46, 355–361 (1982)
Yanase, H.; Sakai, T.; Tonomura, K.: Some properties of a β-cyanoalanine-forming enzyme of Enterobacter sp. 10-1. Agric. Biol. Chem., 46, 363–369 (1982)
Yamagata, S.; Kawai, T.; Takeshima, K.: Partial purification and comparison of some properties of l-serine sulfhydro-lyase of Saccharomyces cerevisiae. Biochim. Biophys. Acta, 701, 334–338 (1982)
Hensel, G.; Trueper, H.G.: O-Acetylserine sulfhydrylase and S-sulfocysteine synthase activities of Rhodospirillum tenue. Arch. Microbiol., 134, 227–232 (1983)
Rosichan, J.L.; Blake, N.; Stallard, R.; Owais, W.M.; Kleinhofs, A.; Nilan, R.A.: O-acetylserine (thiol)-lyase from barley converts sodium azide to a mutagenic metabolite. Biochim. Biophys. Acta, 748, 367–373 (1983)
Nakamura, T.; Iwahashi, A.; Eguchi, Y.: Enzymatic proof for the identity of the S-sulfocysteine synthase and cysteine synthase B of Salmonella typhimurium. J. Bacteriol., 158, 1122–1127 (1984)
Burnell, J.N.: Sulfate assimilation in C4 plants. Plant Physiol., 75, 873–875 (1984)
Nagasawa, T.; Dhillon, G.S.; Ishii, T.; Yamada, H.: Enzymatic synthesis of l-cysteine by O-acetylserine sulfhydrylase of 3-chloro-l-alanine resistant Bacillus sphaericus l-118. J. Bacteriol., 2, 365–367 (1985)
Murakoshi, I.; Ikegami, F.; Kaneko, M.: Purification and properties of cysteine synthase from Spinacia oleracea. Phytochemistry, 24, 1907–1911 (1985)
Byrne, C.R.; Monroe, R.S.; Ward, K.A.; Kredich, N.M.: DNA sequences of the cysK regions of Salmonella typhimurium and Escherichia coli and linkage of the cysK regions to ptsH. J. Bacteriol., 170, 3150–3157 (1988)
Ikegami, F.; Kaneko, M.; Kobori, M.; Murakoshi, I.: Purification and characterization of cysteine synthase from Brassica juncea. Phytochemistry, 27, 3379–3383 (1988)
Ikegami, F.; Kaneko, M.; Kamiyama, H.; Murakoshi, I.: Purification and characterization of cysteine synthases from Citrullus vulgaris. Phytochemistry, 27, 697–701 (1988)
Ikegami, F.; Kaneko, M.; Lambein, F.; Kuo, Y.-H.; Murakoshi, I.: Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum. Phytochemistry, 26, 2699–2704 (1987)
Leon, J.; Romero, L.C.; Galvan, F.; Vega, J.M.: Purification and physicochemical characterization of O-acetyl-l-serine sulfhydrylase from Chlamydomonas reinhardtii. Plant Sci., 53, 93–99 (1953)
Krauss, F.; Schmidt, A.: Sulfur sources for growth of Chlorella fusca and their influence on key enzymes of sulfur metabolism. J. Gen. Microbiol., 133, 1209–1319 (1987)
Ostergaard, S.; Theilgaard, H.B.A.; Nielsen, J.: Identification and purification of O-acetyl-l-serine sulphhydrylase in Penicillium chrysogenum. Appl. Microbiol. Biotechnol., 50, 663–668 (1998)
Yamaguchi, T.; Masada, M.: Comparative studies on cysteine synthase isozymes from spinach leaves. Biochim. Biophys. Acta, 1251, 91–98 (1995)
Ikegami, F.; Itagaki, S.; Murakoshi, I.: Purification and characterization of two forms of cysteine synthase from Allium tuberosum. Phytochemistry, 32, 31–34 (1993)
Leon, J.; Vega, J.M.: Separation and regulatory properties of O-acetyl-l-serine sulfhydrylase isoenzymes from Chlamydomonas reinhardtii. Plant Physiol. Biochem., 29, 595–599 (1991)
Maruyama, A.; Ishizawa, K.; Takagi, T.; Esashi, Y.: Cytosolic β-cyanoalanine synthase activity attributed to cysteine synthases in cocklebur seeds. Purification and characterization of cytosolic cysteine synthases. Plant Cell Physiol., 39, 671–680 (1998)
Leon, J.; Vega, J.M.: Effect of immobilization on the kinetic ans stability properties of o-acetyl-l-serine sulfhydrylase from Chlamydomonas reinhardtii. Biocatalysis, 7, 29–35 (1992)
Roemer, S.; d’Harlingue, A.; Camara, B.; Schantz, R.; Kuntz, M.: Cysteine synthase from Capsicum annuum chromoplasts. Characterization and cDNA cloning of an up-regulated enzyme during fruit development. J. Biol. Chem., 267, 17966–17970 (1992)
Hell, R.; Bork, C.; Bogdanova, N.; Frolov, I.; Hauschild, R.: Isolation and characterization of two cDNAs encoding for compartment specific isoforms of O-acetylserine (thiol) lyase from Arabidopsis thaliana. FEBS Lett., 351, 257–262 (1994)
Kuske, C.R.; Ticknor, L.O.; Guzman, E.; Gurley, L.R.; Valdez, J.G.; Thompson, M.E.; Jackson, P.J.: Purification and characterization of O-acetylserine sulfhydrylase isoenzymes from Datura innoxia. J. Biol. Chem., 269, 6223–6232 (1994)
Droux, M.; Ruffet, M.-L.; Douce, R.; Job, D.: Interactions between serine acetyltransferase and O-acetylserine (thiol) lyase in higher plants-structural and kinetic properties of the free and bound enzymes. Eur. J. Biochem., 255, 235–245 (1998)
Rolland, N.; Ruffet, M.-L.; Job, D.; Douce, R.; Droux, M.: Spinach chloroplast 0-acetylserine (thiol)-lyase exhibits two catalytically non-equivalent pyridoxal-5-phosphate-containing active sites. Eur. J. Biochem., 236, 272–282 (1996)
Flint, D.H.; Tuminello, J.F.; Miller, T.J.: Studies on the synthesis of the Fe-S cluster of dihydroxy-acid dehydratase in Escherichia coli crude extract. Isolation of O-acetylserine sulfhydrylases A and B and β-cystathionase based on their ability to mobilize sulfur from cysteine and to participate. J. Biol. Chem., 271, 16053–16067 (1996)
Burkhard, P.; Rao, G.S.J.; Hohenester, E.; Schnackerz, K.D.; Cook, P.F.; Jansonius, J.N.: Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium. J. Mol. Biol., 283, 121–133 (1998)
Yamaguchi, T.; Zhu, X.; Masada, M.: Purification and characterization of a novel cysteine synthase isozyme from spinach hydrated seeds. Biosci. Biotechnol. Biochem., 62, 501–507 (1998)
Zhu, X.; Yamaguchi, T.; Masada, M.: Complexes of serine acetyltransferase and isoenzymes of cysteine synthase in spinach leaves. Biosci. Biotechnol. Biochem., 62, 947–952 (1997)
Droux, M.; Martin, J.; Sajus, P.; Douce, R.: Purification and characterization of O-acetylserine (thiol) lyase from spinach chloroplasts. Arch. Biochem. Biophys., 295, 379–390 (1992)
Rolland, N.; Droux, M.; Lebrun, M.; Douce, R.: O-acetylserine(thiol)lyase from spinach (Spinacia oleracea L.) leaf: cDNA cloning, characterization, and overexpression in Escherichia coli of the chloroplast isoform. Arch. Biochem. Biophys., 300, 213–222 (1993)
Tai, C.-H.; Nalabolu, S.R.; Jacobson, T.M.; Minter, D.E.; Cook, P.F.: Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants. Biochemistry, 32, 6433–6442 (1993)
Schnackerz, K.D.; Tai, C.-H.; Simmons, J.W.; Jacobson, T.M.; Rao, G.S.J.; Cook, P.F.: Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction. Biochemistry, 34, 12152–12160 (1995)
Owais, W.M.; Gharaibeh, R.: Cloning of the E. coli O-acetylserine sulfhydrylase gene: ability of the clone to produce a mutagenic product from azide and O-acetylserine. Mut. Res., 245, 151–155 (1990)
Ikegami, F.; Kamiya, M.; Kuo, Y.-H.; Lambein, F.; Murakoshi, I.: Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species. Biol. Pharm. Bull., 19, 1214–1215 (1996)
Warrilow, A.G.S.; Hawkesford, M.J.: Cysteine synthase (O-acetylserine (thiol) lyase) substrate specificities classify the mitochondrial isoform as a cyanoalanine synthase. J. Exp. Bot., 51, 985–993 (2000)
Romero, L.C.; Dominguez-Solis, J.R.; Gutierrez-Alcala, G.; Gotor, C.: Salt regulation of O-acetylserine(thiol)lyase in Arabidopsis thaliana and increased tolerance in yeast. Plant Physiol. Biochem., 39, 643–647 (2001)
Noji, M.; Saito, K.: Molecular and biochemical analysis of serine acetyltransferase and cysteine synthase towards sulfur metabolic engineering in plants. Amino Acids, 22, 231–243 (2002)
Tai, C.-H.; Burkhard, P.; Gani, D.; Jenn, T.; Johnson, C; Cook, PR: Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase. Biochemistry, 40, 7446–7452 (2001)
Mino, K.; Yamanoue, T.; Sakiyama, T.; Eisaki, N.; Matsuyama, A.; Nakanishi, K.: Effects of bienzyme complex formation of cysteine synthetase from Escherichia coli on some properties and kinetics. Biosci. Biotechnol. Biochem., 64, 1628–1640 (2000)
Mizuno, Y.; Miyashita, Y.; Yamagata, S.; Iwama, T.; Akamatsu, T.: Cysteine synthase of an extremely thermophilic bacterium, Thermus thermophilus HB8. Biosci. Biotechnol. Biochem., 66, 549–557 (2002)
Borup, B.; Ferry, J.G.: Cysteine biosynthesis in the Archaea: Methanosarcina thermophila utilizes O-acetylserine sulfhydrylase. FEMS Microbiol. Lett., 189, 205–210 (2000)
Mino, K.; Ishikawa, K.: Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1. J. Bacteriol., 185, 2277–2284 (2003)
Borup, B.; Ferry, J.G.: O-Acetylserine sulfhydrylase from Methanosarcina thermophila. J. Bacteriol., 182, 45–50 (2000)
Burandt, P.; Schmidt, A.; Papenbrock, J.: Three O-acetyl-l-serine(thiol)lyase isoenzymes from Arabidopsis catalyse cysteine synthesis and cysteine desulfuration at different pH values. J. Plant Physiol., 159, 111–119 (2002)
Maruyama, A.; Saito, K.; Ishizawa, K.: β-Cyanoalanine synthase and cysteine synthase from potato: molecular cloning, biochemical characterization, and spatial and hormonal regulation. Plant Mol. Biol., 46, 749–760 (2001)
Mino, K.; Ishikawa, K.: Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1. J. Bacteriol., 185, 2277–2284 (2003)
Bettati, S.; Benci, S.; Campanini, B.; Raboni, S.; Chirico, G.; Beretta, S.; Schnackerz, K.D.; Hazlett, T.L.; Gratton, E.; Mozzarelli, A.: Role of pyridoxal 5′-phosphate in the structural stabilization of O-acetylserine sulfhydrylase. J. Biol. Chem., 275, 40244–40251 (2000)
Daum, S.; Tai, C.-H.; Cook, P.F.: Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the α,β-elimination reaction. Biochemistry, 42, 106–113 (2003)
Burkhard, P.; Tai, C.H.; Jansonius, J.N.; Cook, P.F.: Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound. J. Mol. Biol., 303, 279–286 (2000)
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(2007). Cysteine synthase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 · Transferases VI. Springer Handbook of Enzymes, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49755-4_17
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