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Hypoxia-Mediated Chronic Normal Tissue Injury

A New Paradigm and Potential Strategies for Intervention

  • Chapter
Late Effects of Cancer Treatment on Normal Tissues

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The tolerance of normal tissues to irradiation remains the major limitation to the use of ionizing radiation in the treatment of many malignancies. Recent progress in understanding the mechanisms underlying the development of late injury following cancer treatment points toward chronic hypoxia and oxidative stress as an important contributor to this problem. In this chapter, the authors review the evidence to support this new paradigm of late normal tissue injury and discuss potential approaches to the prevention and treatment of this condition.

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Authors and Affiliations

  1. Department of Radiation Oncology, Virginia Commonwealth University Medical Center, Box 980058, 401 College Street, Richmond, VA, 23298-0058, USA

    Mitchell Steven Anscher MD

  2. Department of Radiation Oncology, Duke University Medical Center, Box 3085 DUMC, Durham, NC, 27710, USA

    Zeljko Vujaskovic MD, PhD

Authors
  1. Mitchell Steven Anscher MD
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  2. Zeljko Vujaskovic MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Philip Rubin MD (Professor Emeritus, Chair Emeritus) & Paul Okunieff MD (Philip Rubin Professor of Radiation Oncology, Chair) (Professor Emeritus, Chair Emeritus) &  (Philip Rubin Professor of Radiation Oncology, Chair)

  2. Department of Radiation Oncology, Departments of Radiation Oncology and Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Louis S. Constine MD (Professor of Radiation Oncology and Pediatrics, Vice Chair) (Professor of Radiation Oncology and Pediatrics, Vice Chair)

  3. Department of Radiation Oncology, Duke University Medical Center, P.O. Box 3085, Durham, NC, 27710, USA

    Lawrence B. Marks MD (Professor) (Professor)

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© 2008 Springer-Verlag Berlin Heidelberg

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Anscher, M.S., Vujaskovic, Z. (2008). Hypoxia-Mediated Chronic Normal Tissue Injury. In: Rubin, P., Constine, L.S., Marks, L.B., Okunieff, P. (eds) Late Effects of Cancer Treatment on Normal Tissues. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49070-8_8

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  • DOI: https://doi.org/10.1007/978-3-540-49070-8_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-49069-2

  • Online ISBN: 978-3-540-49070-8

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