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Natural History of Prostatic Carcinoma: The Pathologist’s Perspective

  • Chapter
Prostate Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 175))

Abstract

The stem (basal) cells of prostate acini are considered the origin of prostate cancer. Between these cells and the final secretory cells, different intermediate or transit cells can be observed, and every one of them can evolve into malignant cells, explaining the biological variability of prostatic cancer. The exact changes between normal gland and prostatic intraepithelial neoplasia (PIN) are not yet known, but a post-inflammatory atrophy lesion is being studied in this respect. The PIN lesion is considered the pre-invasive change of prostatic cancer and its presence in needle biopsy is clinically used for follow-up of the patient. The progressive knowledge of the stromal invasion in prostate cancer (loss of some cell-cell adhesion molecules and expression of others) can be correlated with the Gleason grading system, and the molecular changes in the progression to androgen-independent carcinoma can be used as a prognostic marker in conjunction with the classical pathological markers.

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Author information

Authors and Affiliations

  1. Department of Morphologic Sciences Faculty of Medicine, Universitat Autónoma de Barcelona (UAB), Cartagena 340-350, 08025, Barcelona, Spain

    Dr. Ferran Algaba (Head of the Department of Pathology Fundacion Puigvert)

  2. Clínica Plató Fundació Privada, c/Plató 21, 08006, Barcelona, Spain

    Dr. Isabel Trias (Director of the Department of Pathology)

  3. Pathology Section, Fundacion Puigvert — Barcelona, Calle Cartagena 340-350, 08025, Barcelona, Spain

    Dr. Yolanda Arce

Authors
  1. Dr. Ferran Algaba
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  2. Dr. Isabel Trias
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  3. Dr. Yolanda Arce
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Editor information

Editors and Affiliations

  1. The Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, 52621, Israel

    Jacob Ramon MD

  2. Lange Gasthuisstraat 35-37, 2000, Antwerp, Belgium

    Louis J. Denis MD, FACS (Director Oncology Centre Antwerp Secretary Europa Uomo) (Director Oncology Centre Antwerp Secretary Europa Uomo)

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Algaba, F., Trias, I., Arce, Y. (2007). Natural History of Prostatic Carcinoma: The Pathologist’s Perspective. In: Ramon, J., Denis, L.J. (eds) Prostate Cancer. Recent Results in Cancer Research, vol 175. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-40901-4_2

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  • DOI: https://doi.org/10.1007/978-3-540-40901-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40897-0

  • Online ISBN: 978-3-540-40901-4

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