Abstract
Sentinel lymph node (SLN) localisation and biopsy represent one of the most important developments in surgery and have already produced important changes in the management of patients affected by early infiltrating breast carcinoma. Sentinel lymph node biopsy (SLNB) was first applied in melanoma patients by Morton and colleagues (Morton et al. 1992); they intra-operatively injected the patent with vital blue dye close to the primary lesion, and the blue-stained SLN was later found by dissection, following tracer diffusion.
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References
Alazraki NP, Styblo T, Grant SF et al (2000) Sentinel node staging of early breast cancer using lymphoscintigraphy and the intraoperative gamma-detecting probe. Semin Nucl Med 30:56–64
Albo D, Ames FC, Hunt KK et al (2003) Evaluation of lymph node status in male breast cancer patients: a role for sentinel lymph node biopsy. Breast Cancer Res Treat 77:9–14
Andea AA, Wallis T, Newman LA et al (2002) Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma. Cancer 94:1383–1390
Anderson BO (2003) Sentinel lymphadenectomy in breast cancer: an update on the NCCN Clinical Practice Guidelines. J Natl Compr Cancer Network 1:S64–S70
Bedrosian I, Reynolds C, Mick R et al (2000) Accuracy of sentinel lymph node biopsy in patients with large primary breast tumors. Cancer 88:2540–2545
Berry D, Theriault R, Holmes F et al (1999) Management of breast cancer during pregnancy using a standardized protocol. J Clin Oncol 17:855–861
Borgstein PJ, Meijr S, Pijpers R (1997) Intradermal blue dye to identify sentinel lymph node in breast cancer. Lancet 349:1668–1669
Borgstein P, Meijier S (1998) Historical perspective of lymphatic tumour spread and the emergence of the sentinel node concept. Eur J Surg Oncol 24:85–89
Borgstein PJ, Pijpers R, Comans EF et al (1998) Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe detection. J Am Coll Surg 186:275–283
Borgstein PJ, Meijer S, Pijpers RJ et al (2000) Functional lymphatic anatomy in breast cancer: echoes from the past and the periareolar blue method. Ann Surg 232:81–89
Bostick PJ, Huynh KT, Sarantou T et al (1998) Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple-marker RT-PCR. Int J Cancer 79:645–651
Bostick PJ, Chatteriee S, Chi DD et al (1998) Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients. J Clin Oncol 16:2632–2640
Brady EW (2002) Sentinel lymph node mapping following neoadjuvant chemotherapy for breast cancer. Breast J 8:97–100
Brady Breast Study announcements. Durham, N.C.: American College of Surgeons Oncology Group, 2003. (Accessed July 18, 2003 at www.asocog.org/studies/organ_site/breast/.)
Breslin TM, Cohen L, Sahin A et al (2000) Sentinel lymph node biopsy is accurate after neoadjuvant chemotherapy for breast cancer. J Clin Oncol 18:3480–3486
Carter BA, Jensesn RA, Simpson JF et al (2000) Benign transport of breast epithelium into axillary lymph nodes after biopsy. Am J Pathol 113:259–265
Chilosi M, Lestani M, Pedron S et al (1994) A rapid immunostaining method for frozen sections. Biotech Histochem 69:235–239
Chu KU, Turner RR, Hansen NM et al (1999) Do all patients with sentinel node metastasis from breast carcinoma need complete axillary node dissection? Ann Surg 229:536–541
Cimmino VM, Degnim YC, Sabel HS et al (2004) Efficacy of sentinel lymph node biopsy in male breast cancer. J Surg Oncol 86:74–77
Clarke D, Khonji NI, Mansel ER (2001) Sentinel node biopsy in breast cancer: ALMANAC trial. World J Surg 25:819–822
Cody HS 3rd, Borgen PI (1999) State-of-the-art approaches to sentinel node biopsy for breast cancer: study design, patient selection, technique, and quality control at Memorial Sloan-Kettering Cancer Center. Surg Oncol 8:85–91
Cody HS 3rd (2003) Sentinel lymph node biopsy for breast cancer: does anybody not need one? Ann Surg Oncol 10(10):1131–1132
Cohen LF, Breslin TM, Kuerer HM et al (2000) Identification and evaluation of axillary sentinel lymph nodes in patients with breast carcinoma treated with neoadjuvant chemotherapy. Am J Surg Pathol 24:1266–1272
Cote RJ, Peterson HF, Chaiwun B et al (1999) Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. Lancet 354:896–900
Cox CE, Bass SS, Reintgen DS (1999) Techniques for lymphatic mapping in breast carcinoma. Surg Oncol Clin North Am 8:447–468
Cox CE, Nguyen K, Gray RJ et al (2001) Importance of lymphatic mapping in ductal carcinoma in situ (DCIS): why map DCIS? Am J Surg 67:513–519
De Cicco C, Cremonesi M, Luini A et al (1998) Lymphoscintigraphy and radioguided biopsy of the sentinel axillary node in breast cancer. J Nucl Med 39:2080–2084
De Cicco C, Baio SM, Veronesi P et al (2004) Sentinel node biopsy in male breast cancer. Nucl Med Commun 25:139–143
Dowlatshahi K, Fan M, Snider HC et al (1997) Lymph node micrometastases from breast carcinoma. Reviewing the dilemma. Cancer 80:1188–1197
Fenaroli P, Tondini C, Motta T et al (2000) Axillary sentinel node biopsy under local anesthesia in early breast cancer. Ann Oncol 11:1617–1618
Fisher B, Brown A, Mamounas E et al (1997) Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol 15:2483–2493
Fisher B, Jeong JH, Anderson S et al (2002) Twenty-five-year follow up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med 22:567–575
Gennari R, Renne G, Travaini L et al (2001) Sentinel node biopsy in male breast cancer: future standard treatment? Eur J Surg 167:461–462
Gentilini O, Cremonesi M, Trifirò G et al (2004) Safety of sentinel node biopsy in pregnant patients with breast cancer. Ann Oncol 15:1348–1351
Gentilini O, Trifirò G, Soteldo J et al (2006) Sentinel lymph node biopsy in multicentric breast cancer. The experience of the European Institute of Oncology. Eur J Surg Oncol 32(5):507–510
Giuliano AE, Kirgan DM, Guenther JM et al (1994) Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 220:391–401
Giuliano AE, Jones RC, Brennan M et al (1997) Sentinel lymphadenectomy and breast cancer. J Clin Oncol 15:2345–2350
Goyal A, Mansel RE (2004) Multifocality and sentinel node biopsy in breast cancer. Eur J Surg Oncol 30:3–4
Gradishar WJ (2000) Male breast cancer. In: Harris JR, Lippman ME, Morrow M, Osborne CK (eds) Diseases of the breast. Lippincott Williams & Wilkins, Philadelphia, pp 661–667
Grant RN, Tabah EJ, Adair FE (1959) The surgical significance of the subareolar plexus in cancer of the breast. Surgery 33:71–78
Greenlee RT, Murray T, Bolden S et al (2000) Cancer statistics 2000. CA Cancer J Clin 50:7–33
Grube BJ, Giuliano AE (2001) Observation of the breast cancer patient with a tumor-positive sentinel node: implications of the ASOCOG Z0011 trial. Semin Surg Oncol 20:230–237
Halakivi-Clarke L, Cho E, Onojafe I et al (2000) Maternal exposure to tamoxifen during pregnancy increases carcinogen-induced mammary tumorigenesis among female rat offspring. Clin Cancer Res 6:305–308
Handley RS, Trackray AC (1954) Invasion of internal mammary lymph nodes in carcinoma of the breast. Br Med J 1:61–63
Hermanek P, Hutter RVP, Sobin LH et al (1999) International Union Against Cancer. Classification of isolated tumour cells and micrometastasis. Cancer 86:2668–2673
Hill AD, Tran KN, Yeung H et al (1999) Sentinel lymph node biopsy in breast cancer: unfiltered radioisotope is superior to filtered. J Am Coll Surg 188:377–381
Hurkmans CW, Borger JH, Rutgers EJ et al (2003) Quality assurance of axillary radiotherapy in the EORTC AMAROS trial 10981/22023. Radiother Oncol 68:233–240
International (Ludwig) Breast Cancer Study Group (1990) Prognostic importance of occult axillary lymph node micrometastases from breast cancer. Lancet 335:1565–1568
Joshi MG, Lee AK, Loda M et al (1996) Male breast carcinoma: an evaluation of prognostic factors contributing to a poorer outcome. Cancer 77: 490
Kataoka A, Mori M, Sadanaga N et al (2000) RT-PCR detection of breast cancer cells in sentinel lymph nodes. Int J Oncol 16:1147–1152
Keleher A, Wendt III R, Delpassand E et al (2004) The safety of lymphatic mapping in pregnant breast cancer patients using Tc-99m sulphur colloid. Breast J 10:492–495
Keshtgar MRS, Ell PJ (1999) Sentinel lymph node detection and imaging. Eur J Nucl Med 1999 26:57–67
Kim HJ, Heerdt AS et al (2002) Sentinel node drainage in multicentric breast cancers. Breast J 8:356–361
Klauber-DeMore N, Tan LK, Liberman L et al (2000) Sentinel lymph node biopsy: is it indicated in patients with highrisk ductal carcinoma-in-situ and ductal carcinoma-insitu with microinvasion? Ann Surg Oncol 7:636–642
Klimberg VS, Rubio IT, Henry R et al (1999) Subareolar versus peritumoural injection for location of the sentinel lymph node. Ann Surg 229:860–864
Knauer M, Konstantiniuk P, Haid A et al (2006) Multicentric breast cancer: a new indication for sentinel node biopsy — a multi-institutional validation study. J Clin Oncol 24:3374–3380
Krag DN, Weaver DL, Alex JC et al (1993) Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma-probe. Surg Oncol 2:335–340
Krag DN, Weaver D, Ashikaga T et al (1998) The sentinel node in breast cancer — a multicenter validation study. N Engl J Med 339:941–946
Krag DN, Julian T (2002) Expert perspectives: update on NSABP B-32, a randomized phase III clinical trial to compare sentinel node resection to conventional axillary dissection for clinically node-negative breast cancer. Breast Dis Year Book Q 13:113–114
Kumar R, Jana S, Heiba SI et al (2003) Retrospective analysis of sentinel node localization in multifocal, multicentric, palpable, or nonpalpable breast cancer. J Nucl Med 44:7–10
Luini A, Gatti G, Frasson A et al (2002) Sentinel lymph node biopsy performed with local anesthesia in patients with early-stage breast carcinoma. Arch Surg 137:1157–1160
Luini A, Galimberti V, Gatti G et al (2005) The sentinel node biopsy after previous breast surgery: preliminary results on 543 patients treated at the European Institute of Oncology. Breast Cancer Res Treat 89(2):159–163
Mamounas EP (2003) Sentinel lymph node biopsy after neoadjuvant systemic therapy [review]. Surg Clin North Am 83:931–942
Manzotti M, Dell’Orto P, Maisonneuve P et al (2001) Reverse transcription-polymerase chain reaction assay for multiple mRNA markers in the detection of breast cancer metastases in sentinel lymph nodes. Int J Cancer 95:307–312
Mariani G, Moresco L, Viale G et al (2001) Radioguided sentinel lymph node biopsy in breast cancer surgery. J Nucl Med 42:1198–1215
Masuda N, Tamaki Y, Sakita I et al (2000) Clinical significance of micrometastases in axillary lymph nodes assessed by reverse transcription-polymerase chain reaction in breast cancer patients. Clin Cancer Res 6:4176–4185
McMaster KM, Giuliano AE, Ross MI et al (1998) Sentinellymph-node biopsy for breast cancer — not yet the standard of care. N Engl J Med 339:990–995
Miner TJ, Shriver CD, Jaques DP et al (1999) Sentinel lymph node biopsy for breast cancer: the role of previous biopsy on patients eligibility. Am Surg 65:493–499
Morton DL, Wen DR, Wong JH et al (1992) Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 127:392–399
Morton DL, Chan AD (2000) The concept of sentinel node localization: how it started. Semin Nucl Med 30:4–10
Mullan MH, Kissin MW (2001) Positive sentinel node biopsy in male breast carcinoma. ANZ J Surg 71:438–440
Nason KS, Anderson BO, Byrd DR et al (2000) Increased false negative sentinel node biopsy rates after preoperative chemotherapy for invasive breast carcinoma. Cancer 89:2187–2194
Noguchi M, Tsugawa K, Miwa K (2000) Internal mammary chain sentinel lymph node identification in breast cancer patient. J Surg Oncol 73:75–80
Ollila DW, Giuliano AE (1998) Intraoperative lymphatic mapping and sentinel lymphadenectomy using isosulfan blue dye. Breast Dis 8:297–300
Ozmen V, Muslumanoglu M, Cabioglu N et al (2002) Increased false negative rates in sentinel lymph node biopsies in patients with multifocal breast cancer. Breast Cancer Res Treat 76:237–244
Paganelli G, De Cicco C, Cremonesi M et al (1998) Optimized sentinel node scintigraphy in breast cancer. Q J Nucl Med 42:49–53
Paganelli G, Galimberti V, Trifirò G et al (2002) Internal mammary node lymphoscintigraphy and biopsy in breast cancer. Q J Nucl Med 46:138–144
Pendas S, Dauway E, Giuliano R et al (2000) Sentinel node biopsy in DCIS patients. Ann Surg Oncol 7:15–20
Port ER, Fey JV, Cody III HS et al (2001) Sentinel lymph node biopsy in patients with male breast carcinoma. Cancer 91:319–323
Port ER, Fey J, Gemignani ML et al (2002) Reoperative sentinel lymph node biopsy: a new option for patients with primary or locally recurrent breast carcinoma. J Am Coll Surg 195:167–172
Reintgen D, Giuliano R, Cox G (2002) Lymphatic mapping and sentinel lymph node biopsy for breast cancer. Cancer J 8:S15–S21
Reynolds C, Mick R, Donohue JH et al (1999) Sentinel lymph node biopsy with metastasis: can AD be avoided in some patients with breast cancer? J Clin Oncol 17:1720–1726
Ross MI (2001) Sentinel lymph node dissection in early-stage breast cancer: ongoing prospective randomized trials in the USA. Ann Surg Oncol 8:778–818
Roumen RM, Geuskens LM, Valkenburg JG (1999) In search of the true sentinel node by different injection techniques in breast cancer patients. Eur J Surg Oncol 25:347–351
Roumen RM, Geuskens LM, Valkenburg JG (1999) In search of the true sentinel node by different injection techniques in breast cancer patients. Eur J Surg Oncol 25:347–351
Sabel MS, Schott AF, Kleer CG et al (2003) Sentinel node biopsy prior to neoadjuvant chemotherapy. Am J Surg 186:102–105
Schnitt SJ, Silen W, Sadowsky NL et al (1988) Ductal carcinoma in situ. N Engl J Med 318:898–902
Schrenk P, Wayand W (2001) Sentinel-node biopsy in axillary lymph-node staging for patients with multicentric breast cancer. Lancet 357:122
Schwartz GF, Giuliano AE, Veronesi U (2002) Consensus Conference Committee. Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19–22, 2001, Philadelphia, Pennsylvania. Cancer 94:2542–2551
Schwartz GF, Meltzer AJ (2003) Accuracy of axillary sentinel lymph node biopsy following neoadjuvant (induction) chemotherapy for carcinoma of the breast. Breast J 9:374–379
Specht MC, Fey JV, Borgen PI et al (2005) Is the clinically positive axilla in breast cancer really a contraindication to sentinel lymph node biopsy? J Am Coll Surg. 200(1):10–14
Spratt JS, Schieber W, Dillard B (1965) Anatomy and surgical technique of groin dissection. St. Louis: CV Mosby
Stearns V, Ewing CA, Slack R et al (2002) Sentinel lymphadenectomy after neoadjuvant chemotherapy for breast cancer may reliably represent the axilla except for inflamatory breast cancer. Ann Surg Oncol 9:235–242
Tanis PJ, Valdes Olmos RA, Muller SH et al (2003) Lymphatic mapping in patients with breast carcinoma: reproducibility and lymphoscintigraphic results. Radiology 228:313–315
Tousimis E, Van Zee KJ, Fey JV et al (2003) The accuracy of sentinel lymph node biopsy in multicentric and multifocal invasive breast cancers. J Am Coll Surg 197:529–535
Turner RR, Chu KU, Qi K et al (2000) Pathologic features associated with nonsentinel lymph node metastases in patients with metastatic breast carcinoma in a sentinel lymph node. Cancer 89:574–581
Veronesi P, Intra M, Vento AR et al (2005) Sentinel lymph node for localized ductal carcinoma in situ. Breast 14:520–522
Veronesi U, Luini A, Galimberti V et al (1990) Extent of axillary involvement in 1446 cases of breast cancer. Eur J Surg Oncol 16:127–133
Veronesi U, Paganelli G, Galimberti V et al (1997) Sentinelnode biopsy to avoid AD in breast cancer with clinically negative lymph-nodes. Lancet 349:1864–1867
Veronesi U, Paganelli G, Viale G et al (2003) A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med 349:546–553
Viale G, Bosari S, Mazzarol G et al (1999) Intraoperative examination of axillary sentinel lymph nodes in breast carcinoma patients. Cancer 85:2433–2438
Viale G, Maiorano E, Mazzarol G et al (2001) Histologic detection and clinical implications of micrometastases in axillary sentinel lymph nodes for patients with breast carcinoma. Cancer 92:1378–1384
Wilhelm AJ, Mijnhout GS, Franssen EJF (1999) Radiopharmaceuticals in sentinel lymph-node detection — an overview. Eur J Nucl Med 26:S36–S42
Wilke LG, Giuliano AE (2003) Sentinel lymph node biopsy in patients with early-stage breast cancer: status of the National Clinical Trials. Surg Clin North Am 83:901–910
Wong SL, Edwards MJ, Chao C et al (2002) The effect of prior breast biopsy method and concurrent definitive breast procedure on success and accuracy of sentinel lymph node biopsy. Ann Surg Oncol 9:272–277
Woo JC, Yu T, Hurd TC (2003) Breast cancer in pregnancy: a literature review. Arch Surg 138:91–99
Zurrida S, Morabito A, Galimberti V et al (1999) Importance of the level of axillary involvement in relation to traditional variables in the prognosis of breast cancer. Int J Oncol 15:475–480
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Paganelli, G., Trifirò, G., Gentilini, O., Intra, M., Viale, G., Veronesi, U. (2008). Sentinel Node Detection in Pre-Operative Axillary Staging. In: Bombardieri, E., Gianni, L., Bonadonna, G. (eds) Breast Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36781-9_8
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