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Neuroimmunology of the Skin pp 113–123Cite as

Effects of Psychological Stress on Skin Immune Function: Implications for Immunoprotection Versus Immunopathology

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References

  1. Ackerman KD, Heyman R, Rabin BS, Anderson BP, Houck PR, Frank E, Baum A (2002) Stressful life events precede exacerbations of multiple sclerosis. Psychosom Med 64(6):916–920

    Article  PubMed  Google Scholar 

  2. Ader R (2006) Psychoneuroimmunology IV. 4th ed, Academic Press, San Diego, p 1583

    Google Scholar 

  3. Akiyama H, Amano H, Bienenstock J (2005) Rat tracheal epithelial responses to water avoidance stress. J Allergy Clin Immunol 116(2):318–324

    Article  PubMed  Google Scholar 

  4. Al’Abadie MS, Kent GG, Gawkrodger DJ (1994) The relationship between stress and the onset and exacerbation of psoriasis and other skin conditions. Brit J Dermatol 130:199–203

    Article  CAS  Google Scholar 

  5. Altemus M, Rao B, Dhabhar FS, Ding W, Granstein R (2001) Stress-induced changes in skin barrier function in healthy women. J Invest Dermatol 117:309–317

    Article  PubMed  CAS  Google Scholar 

  6. Amkraut AA, Solomon CF, Kraemer HC (1971) Stress, early experience and adjuvant-induced arthritis in the rat. Psychosom Med 33:203–214

    PubMed  CAS  Google Scholar 

  7. Benschop RJ, Oostveen FG, Heijnen CJ, Ballieux RE (1993) Beta 2-adrenergic stimulation causes detachment of natural killer cells from cultured endothelium. Eur J Immunol 23(12):3242–3247

    Article  PubMed  CAS  Google Scholar 

  8. Benschop RJ, Rodriguez-Feuerhahn M, Schedlowski M (1996) Catecholamine-induced leukocytosis: early observations, current research, and future directions. Brain Behav Immun 10(2):77–91

    Article  PubMed  CAS  Google Scholar 

  9. Bilbo SD, Dhabhar FS, Viswanathan K, Saul A, Yellon SM, Nelson RJ (2002) Short day lengths augment stressinduced leukocyte trafficking and stress-induced enhancement of skin immune function. Proc Natl Acad Sci USA 99(6):4067–4072

    Article  PubMed  CAS  Google Scholar 

  10. Bilbo SD, Hotchkiss AK, Chiavegatto S, Nelson RJ (2003) Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. J Neuroimmunol 140(1–2):41–48

    Article  PubMed  CAS  Google Scholar 

  11. Black PH (1994) Immune system-central nervous system interactions: effect and immunomodulatory consequences of immune system mediators on the brain. Antimicrobial Agents Chemother 38(1):7–12

    CAS  Google Scholar 

  12. Blecha F, Barry RA, Kelley KW (1982) Stress-induced alterations in delayed-type hypersensitivity to SRBC and contact sensitivity to DNFB in mice. Proc Soc Exp Biol Med 169:239–246

    PubMed  CAS  Google Scholar 

  13. Borysenko M, Borysenko J (1982) Stress, behavior, and immunity: animal models and mediating mechanisms. General Hospital Psychiatr 4:59–67

    Article  CAS  Google Scholar 

  14. Bosch JA, Berntson GG, Cacioppo JT, Dhabhar FS, Marucha PT (2003) Acute stress evokes selective mobilization of T cells that differ in chemokine receptor expression: a potential pathway linking immunologic reactivity to cardiovascular disease. Brain Behav Immun 17:251–259

    Article  PubMed  CAS  Google Scholar 

  15. Brosschot JF, Benschop RJ, Godaert GL, Olff M, De Smet M, Heijnen CJ, Ballieux RE (1994) Influence of life stress on immunological reactivity to mild psychological stress. Psychosom Med 56(3):216–224

    PubMed  CAS  Google Scholar 

  16. Buske-Kirschbaum A, Geiben A, Hellhammer D (2001) Psychobiological aspects of atopic dermatitis: an overview. Psychother Psychosom 70(1):6–16

    Article  PubMed  CAS  Google Scholar 

  17. Carlson SL, Fox S, Abell KM (1997) Catecholamine modulation of lymphocyte homing to lymphoid tissues. Brain Behav Immun 11(4):307–320

    Article  PubMed  CAS  Google Scholar 

  18. Coe CL, Lubach G, Ershler WB (1989) Immunological consequences of maternal separation in infant primates, in Infant stress and coping, In: Lewis M, Worobey J (ed) Jossey-Bass Inc., New York, NY

    Google Scholar 

  19. Colavincenzo ML, Granstein RD (2006) Stress and the skin: a meeting report of the Weill Cornell symposium on the science of dermatology. J Invest Dermatol 126(12):2560–2561

    Article  PubMed  CAS  Google Scholar 

  20. Cunnick JE, Lysle DT, Kucinski BJ, Rabin BS (1990) Evidence that shock-induced immune suppression is mediated by adrenal hormones and peripheral beta-adrenergic receptors. Pharmacol Biochem Behav 36:645–651

    Article  PubMed  CAS  Google Scholar 

  21. Delgado M, Gonzalez-Rey E, Ganea D (2006) Vasoactive intestinal peptide: the dendritic cell → regulatory T cell axis. Ann NY Acad Sci 1070:233–238

    Article  PubMed  CAS  Google Scholar 

  22. Denda M, Tsuchiya T, Hosoi J, Koyama J (1998) Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin. Br J Dermatol 138(5):780–785

    Article  PubMed  CAS  Google Scholar 

  23. Dhabhar FS (1998) Stress-induced enhancement of cell-mediated immunity. Ann NY Acad Sci 840:359–372

    Article  PubMed  CAS  Google Scholar 

  24. Dhabhar FS, McEwen BS (1996) Stress-induced enhancement of antigen-specific cell-mediated immunity. J Immunol 156:2608–2615

    PubMed  CAS  Google Scholar 

  25. Dhabhar FS, McEwen BS (1997) Acute stress enhances while chronic stress suppresses immune function in vivo: a potential role for leukocyte trafficking. Brain Behav Immun 11(4):286–306

    Article  PubMed  CAS  Google Scholar 

  26. Dhabhar FS, McEwen BS (1999) Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci U S A 96:1059–1064

    Article  PubMed  CAS  Google Scholar 

  27. Dhabhar FS, McEwen BS (2001) Bidirectional effects of stress and glucocorticoid hormones on immune function: possible explanations for paradoxical observations, In: Ader R, Feiten DL, Cohen N (ed) Psychoneuroimmunology, 3rd ed, Academic Press, San Diego, pp 301–338

    Google Scholar 

  28. Dhabhar FS, McEwen BS (2006) Bidirectional effects of stress on immune function: possible explanations for salubrious as well as harmful effects, In: Ader R (ed) Psychoneuroimmunology IV, Elsevier, San Diego, pp 723–760

    Google Scholar 

  29. Dhabhar FS, Viswanathan K (2005) Short-term stress experienced at the time of immunization induces a long-lasting increase in immunological memory. Am J Physiol Regul Integr Comp Physiol 289(3):R738–744

    PubMed  CAS  Google Scholar 

  30. Dhabhar FS, Miller AH, Stein M, McEwen BS, Spencer RL (1994) Diurnal and stress-induced changes in distribution of peripheral blood leukocyte subpopulations. Brain Behav Immun 8:66–79

    Article  PubMed  CAS  Google Scholar 

  31. Dhabhar FS, Miller AH, McEwen BS, Spencer RL (1995) Effects of stress on immune cell distribution — dynamics and hormonal mechanisms. J Immunol 154:5511–5527

    PubMed  CAS  Google Scholar 

  32. Dhabhar FS, Miller AH, McEwen BS, Spencer RL (1996) Stress-induced changes in blood leukocyte distribution — role of adrenal steroid hormones. J Immunol 157:1638–1644

    PubMed  CAS  Google Scholar 

  33. Dhabhar FS, Satoskar AR, Bluethmann H, David JR, McEwen BS (2000) Stress-Induced Enhancement of Skin Immune Function: A Role For IFNγ. Proc Natl Acad Sci USA 97:2846–2851

    Article  PubMed  CAS  Google Scholar 

  34. Donelan J, Boucher W, Papadopoulou N, Lytinas M, Papaliodis D, Dobner P, Theoharides TC (2006) Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependen process. Proc Natl Acad Sci USA 103(20):7759–7764

    Article  PubMed  CAS  Google Scholar 

  35. Fauci AS, Dale DC (1974) The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. J Clin Invest 53:240–246

    Article  PubMed  CAS  Google Scholar 

  36. Fauci AS, Dale DC (1975) The effect of hydrocortisone on the kinetics of normal human lymphocytes. Blood 46:235–243

    PubMed  CAS  Google Scholar 

  37. Flint MS, Miller DB, Tinkle SS (2000) Restraint-induced modulation of allergic and irritant contact dermatitis in male and female B6.129 mice. Brain Behav Immun 14(4):256–269

    Article  PubMed  CAS  Google Scholar 

  38. Flint MS, Valosen JM, Johnson EA, Miller DB, Tinkle SS (2001) Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge. J Neuroimmunol 113(1):72–80

    Article  PubMed  CAS  Google Scholar 

  39. Garg A, Chren MM, Sands LP, Matsui MS, Marenus KD, Feingold KR, Elias PM (2001) Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch Dermatol 137(1):53–59

    PubMed  CAS  Google Scholar 

  40. Glaser R, Kiecolt-Glaser JK (2005) Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 5(3):243–251

    Article  PubMed  CAS  Google Scholar 

  41. Goldstein DS, McEwen B (2002) Allostasis, homeostats, and the nature of stress. Stress 5(1):55–58

    Article  PubMed  Google Scholar 

  42. Granstein RD, Matsui MS (2004) UV radiation-induced immunosuppression and skin cancer. Cutis 74(5 Suppl):4–9

    PubMed  Google Scholar 

  43. Herbert TB, Cohen S (1993) Stress and immunity in humans: a meta-analytic review. Psychosom Med 55:364–379

    PubMed  CAS  Google Scholar 

  44. Hoagland H, Elmadjian F, Pincus G (1946) Stressful psychomotor performance and adrenal cortical function as indicated by the lymphocyte reponse. J Clin Endocrinol 6:301–311

    Article  Google Scholar 

  45. Hosoi J, Tsuchiya T, Denda M, Ashida Y, Takashima A, Granstein RD, Koyama J (1998) Modification of LC phenotype and suppression of contact hypersensitivity response by stress. J Cutan Med Surg 3(2):79–84

    PubMed  CAS  Google Scholar 

  46. Irwin M (1994) Stress-induced immune suppression: role of brain corticotropin releasing hormone and autonomic nervous system mechanisms. Adv Neuroimmunol 4:29–47

    Article  PubMed  CAS  Google Scholar 

  47. Irwin M, Patterson T, Smith TL, Caldwell C, Brown SA, Gillin CJ, Grant I (1990) Reduction of immune function in life stress and depression. Biol Psychiatr. 27:22–30

    Article  CAS  Google Scholar 

  48. Jensen MM (1969) Changes in leukocyte counts associated with various Stressors. J Reticuloendothelial Soc 8:457–465

    Google Scholar 

  49. Khansari DN, Murgo AJ, Faith RE (1990) Effects of stress on the immune system. Immunol Today 11(5):170–175

    Article  PubMed  CAS  Google Scholar 

  50. Kort WJ (1994) The effect of chronic stress on the immune system. Adv Neuroimmunol 4:1–11

    Article  PubMed  CAS  Google Scholar 

  51. Kripke ML (1994) Ultraviolet radiation and immunology: something new under the sun — presidential address. Cancer Res 54(23):6102–6105

    PubMed  CAS  Google Scholar 

  52. Manuck SB, Cohen S, Rabin BS, Muldoon MF, Bachen EA (1991) Individual differences in cellular immune response to stress. Psychol Sci 2(2):111–115

    Article  Google Scholar 

  53. McEwen BS (1998) Protective and damaging effects of stress mediators: allostasis and allostatic load. NEJM 338(3):171–179

    Article  PubMed  CAS  Google Scholar 

  54. McEwen BS (2002) The End of Stress As We Know It. Dana Press, Washington, DC, p 239

    Google Scholar 

  55. Miller AH, Spencer RL, Hasset J, Kim C, Rhee R, Cira D, Dhabhar FS, McEwen BS, Stein M (1994) Effects of selective Type I and Type II adrenal steroid receptor agonists on immune cell distribution. Endocrinology 135(5):1934–1944

    Article  PubMed  CAS  Google Scholar 

  56. Mills PJ, Berry CC, Dimsdale JE, Ziegler MG, Nelesen RA, Kennedy BP (1995) Lymphocyte subset redistribution in response to acute experimental stress: effects of gender, ethnicity, hypertension, and the sympathetic nervous system. Brain Behav Immun 9:61–69

    Article  PubMed  CAS  Google Scholar 

  57. Mills PJ, Ziegler MG, Rehman J, Maisel AS (1998) Catecholamines, catecholamine receptors, cell adhesion molecules, and acute stressor-related changes in cellular immunity. Adv Pharmacol 42:587–590

    Article  PubMed  CAS  Google Scholar 

  58. Mills PJ, Meck JV, Waters WW, D’Aunno D, Ziegler MG (2001) Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Psychosom Med 63(6):886–890

    PubMed  CAS  Google Scholar 

  59. Monjan AA, Collector MI (1977) Stress-induced modulation of the immune response. Science 196:307–308

    Article  PubMed  CAS  Google Scholar 

  60. Morrow-Tesch JL, McGlone JJ, Norman RL (1993) Consequences of restraint stress on natural killer cell activity, behavior, and hormone levels in Rhesus Macaques (Macaca mulatto). Psychoneuroendocrinol 18:383–395

    Article  CAS  Google Scholar 

  61. Naliboff BD, Benton D, Solomon GF, Morley JE, Fahey JL, Bloom ET, Makinodan T, Gilmore SL (1991) Immunological changes in young and old adults during brief laboratory stress. Psychosom Med 53:121–132

    PubMed  CAS  Google Scholar 

  62. Paus R, Botchkarev VA, Botchkareva NV, Mecklenburg L, Luger T, Slominski A (1999) The skin POMC system (SPS). Leads and lessons from the hair follicle. Ann NY Acad Sci 885:350–363

    Article  PubMed  CAS  Google Scholar 

  63. Pickford GE, Srivastava AK, Slicher AM, Pang PKT (1971) The stress response in the abundance of circulating leukocytes in the Killifish, Fundulus heteroclitus. I. The cold-shock sequence and the effects of hypophysectomy. J Exp Zool 177:89–96

    Article  PubMed  CAS  Google Scholar 

  64. Pruett SB (2001) Quantitative aspects of stress-induced immunomodulation. Int Immunopharmacol 1(3):507–520

    Article  PubMed  CAS  Google Scholar 

  65. Redwine L, Snow S, Mills P, Irwin M (2003) Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression. Psychosom Med 65(4):598–603

    Article  PubMed  CAS  Google Scholar 

  66. Redwine L, Mills PJ, Sada M, Dimsdale J, Patterson T, Grant I (2004) Differential immune cell chemotaxis responses to acute psychological stress in Alzheimer caregivers compared to non-caregiver controls. Psychosom Med 66(5):770–775

    Article  PubMed  Google Scholar 

  67. Rinder CS, Mathew JP, Rinder HM, Tracey JB, Davis E, Smith BR (1997) Lymphocyte and monocyte subset changes during cardiopulmonary bypass: effects of aging and gender [see comments]. J Lab Clin Med 129(6):592–602

    Article  PubMed  CAS  Google Scholar 

  68. Rinner I, Schauenstein K, Mangge H, Porta S, Kvetnansky R (1992) Opposite effects of mild and severe stress on in vitro activation of rat peripheral blood lymphocytes. Brain Behav Immun 6:130–140

    Article  PubMed  CAS  Google Scholar 

  69. Saint-Mezard P, Chavagnac C, Bosset S, Ionescu M, Peyron E, Kaiserlian D, Nicolas JF, Berard F (2003) Psychological stress exerts an adjuvant effect on skin dendritic cell functions in vivo. J Immunol 171(8):4073–4080

    PubMed  CAS  Google Scholar 

  70. Sapolsky RM (2004) Why Zebras Don’t Get Ulcers, 3rd ed. W.H. Freeman and Company, San Fransisco, CA, p 560

    Google Scholar 

  71. Sapolsky RM (2005) The influence of social hierarchy on primate health. Science 308:648–652

    Article  PubMed  CAS  Google Scholar 

  72. Saul AN, Oberyszyn TM, Daugherty C, Kusewitt D, Jones S, Jewell S, Malarkey WB, Lehman A, Lemeshow S, Dhabhar FS (2005) Chronic stress and susceptibility to skin cancer. J Nat Cancer Institute 97:1760–1767

    CAS  Google Scholar 

  73. Schedlowski M, Jacobs R, Stratman G, Richter S, Hädike A, Tewes U, Wagner TOF, Schmidt RE (1993) Changes of natural killer cells during acute psychological stress. J Clin Immunol 13(2):119–126

    Article  PubMed  CAS  Google Scholar 

  74. Schwab CL, Fan R, Zheng Q, Myers LP, Hebert P, Pruett SB (2005) Modeling and predicting stress-induced immunosuppression in mice using blood parameters. Toxicol Sci 83(1):101–113

    Article  PubMed  CAS  Google Scholar 

  75. Seiffert K, Granstein RD (2006) Neuroendocrine regulation of skin dendritic cells. Ann N Y Acad Sci 1088:195–206

    Article  PubMed  CAS  Google Scholar 

  76. Sklar LS, Anisman H (1981) Stress and cancer. Psychol Bull 89(3):369–406

    Article  PubMed  CAS  Google Scholar 

  77. Slominski A, Wortsman J, Luger T, Paus R, Solomon S (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80(3):979–1020

    PubMed  CAS  Google Scholar 

  78. Smith A, Vollmer-Conna U, Bennett B, Wakefield D, Hickie I, Lloyd A (2004) The relationship between distress and the development of a primary immune response to a novel antigen. Brain Behav Immun 18(1):65–75

    Article  PubMed  CAS  Google Scholar 

  79. Snow DH, Ricketts SW, Mason DK (1983) Hematological responses to racing and training exercise in Thoroughbred horses, with particular reference to the leukocyte response. Equine Vet J 15(2):149–154

    Article  PubMed  CAS  Google Scholar 

  80. Sprent J, Tough DF (1994) Lymphocyte life-span and memory. Science 265:1395–1400

    Article  PubMed  CAS  Google Scholar 

  81. Stein M, Ronzoni E, Gildea EF (1951) Physiological responses to heat stress and ACTH of normal and schizophrenic subjects. Am J Psychiatr 6:450–455

    Google Scholar 

  82. Steinhoff M, Stander S, Seeliger S, Ansel JC, Schmelz M, Luger T (2003) Modern aspects of cutaneous neurogenic inflammation. Arch Dermatol 139(11):1479–1488

    Article  PubMed  Google Scholar 

  83. Theoharides TC, Kalogeromitros D (2006) The critical role of mast cells in allergy and inflammation. Ann NY Acad Sci 1088:78–99

    Article  PubMed  CAS  Google Scholar 

  84. Toft P, Svendsen P, Tonnesen E, Rasmussen JW, Christensen NJ (1993) Redistribution of lymphocytes after major surgical stress. Acta Anesthesiol Scand 37:245–249

    Article  CAS  Google Scholar 

  85. Viswanathan K, Dhabhar FS (2005) Stress-induced enhancement of leukocyte trafficking into sites of surgery or immune activation. Proc Natl Acad Sci USA 102(16):5808–5813

    Article  PubMed  CAS  Google Scholar 

  86. Viswanathan K, Daugherty C, Dhabhar FS (2005) Stress as an endogenous adjuvant: augmentation of the immunization phase of cell-mediated immunity. Int Immunol 17(8):1059–1069

    Article  PubMed  CAS  Google Scholar 

  87. Weston WL, Huff JC (1976) Atopic dermatitis: etiology and pathogenesis. Pediatr Ann 5(12):759–762

    PubMed  CAS  Google Scholar 

  88. Wood PG, Karol MH, Kusnecov AW, Rabin BS (1993) Enhancement of antigen-specific humoral and cell-mediated immunity by electric footshock stress in rats. Brain Behav Immun 7:121–134

    Article  PubMed  CAS  Google Scholar 

  89. Zalcman S, Anisman H (1993) Acute and chronic Stressor effects on the antibody response to sheep red blood cells. Pharmacol Biochem Behav 46(2):445–452

    Article  PubMed  CAS  Google Scholar 

  90. Zwilling B (1992) Stress affects disease outcomes. Confronted with infectious disease agents, the nervous and immune systems interact in complex ways. ASM News 58(1):23–25

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry & Behavioral Sciences Immunology Program, Neuroscience Institute, & Cancer Center, Stanford University, 300 Pasteur Drive, MC 5135, Stanford, CA, 94305-5135

    F. S. Dhabhar

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  1. F. S. Dhabhar
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Editors and Affiliations

  1. Weill Cornell Medical College Department of Dermatology, Cornell University, 1300 York Ave., 10021, New York, NY, USA

    Richard D. Granstein MD

  2. Medizinische Einrichtungen Klinik und Poliklinik für, Universitätsklinikum Münster, Von-Esmarch-Str. 56, 48149, Münster, Germany

    Thomas A. Luger MD

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Dhabhar, F.S. (2009). Effects of Psychological Stress on Skin Immune Function: Implications for Immunoprotection Versus Immunopathology. In: Granstein, R.D., Luger, T.A. (eds) Neuroimmunology of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_11

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