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Oculoplastics and Orbit pp 123–141Cite as

Thyroid-related Orbitopathy: New Immunologic Concepts and Future Implications

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Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

Abstract

Graves’ disease (GD) is a systemic autoimmune disease that targets the thyroid, orbit, and skin. Thyroid-associated orbitopathy (TAO) describes the orbital and periorbital manifestations of the disease [33, 34, 159]. Several important concepts have emerged in the pathogenesis of TAO that potentially explain the manifestations of the disease. Immune recognition of “foreign” and “self ” is predicated upon molecular recognition of target structures. The mechanisms of immune recognition and discrimination of self and nonself is beyond the scope of this chapter, but several important epitopes or molecular targets have emerged that may prove relevant to the pathogenesis of TAO and GD. It is increasingly clear that a single target may not fully explain the diverse systemic- and anatomic-specific disease manifestations.

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(2007). Thyroid-related Orbitopathy: New Immunologic Concepts and Future Implications. In: Guthoff, R., Katowitz, J. (eds) Oculoplastics and Orbit. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33677-8_8

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