Skip to main content
SpringerLink
Log in
Book cover

Management des Mammakarzinoms pp 119–125Cite as

Genetische Veränderungen des sporadischen Mammakarzinoms

  • Chapter

  • 1337 Accesses

Part of the book series: Onkologie aktuell ((ONKAKTUELL))

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Arnold N, Hägele L, Walz L, Schempp W, Pfisterer J, Bauknecht T, Kiechle M (1996) Overrepresentation of 3q and 8q material and loss of 18q material are recurrent findings in advanced human ovarian cancer. Genes Chromosomes Cancer 16: 46–54

    Article  PubMed  CAS  Google Scholar 

  • Caldes T, Perez-Segura P, Tosar A, De La Hoya M, Diaz-Rubio E (2000) Low frequency of microsatellite instability in sporadic breast cancer. Int J Oncol 16: 1235–1242

    PubMed  CAS  Google Scholar 

  • Cheng C-W, Wu P-E, Yu J-C, Huang C-S, Yue C-T, Wu C-W, Shen C-Y (2001) Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 20: 3814–3823

    Article  PubMed  CAS  Google Scholar 

  • Chin K, De Solorzano CO, Knowles D et al. (2004) In situ analyses of genome instability in breast cancer. Nat Genet 36: 984–988

    Article  PubMed  CAS  Google Scholar 

  • De Pinho RA, Polyak K (2004) Cancer chromosomes in crisis. Nat Genet 36: 932–934

    Article  Google Scholar 

  • Esteller M, Silva JM, Dominguez G et al. (2000) Promotor hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 92: 564–569

    Article  PubMed  CAS  Google Scholar 

  • Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759–767

    Article  PubMed  CAS  Google Scholar 

  • Feinberg AP (2001) Cancer epigenetics takes center stage. Proc Natl Acad Sci USA 98: 392–394

    Article  PubMed  CAS  Google Scholar 

  • Forozan F, Mahlamäki EH, Monni O et al. (2000) Comparative Genomic Hybridization analysis of 38 breast cancer cell lines: A basis for interpreting complementary DNA microarray data. Cancer Res 60:4519–4525

    PubMed  CAS  Google Scholar 

  • Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG (2000) Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 275: 2727–2732

    Article  PubMed  CAS  Google Scholar 

  • Jain AN, Chin K, Boerresen-Dale AL, Erikstein BK, Lonning PE, Kaaresen R, Gray JW (2001) Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival. Proc Natl Acad Sci USA 98: 7952–7957

    Article  PubMed  CAS  Google Scholar 

  • Lin NU, Winer EP (2004). New targets for therapy in breast cancer: Small molecule tyrosine kinase inhibitors. Breast Cancer Res 6: 204–210

    Article  PubMed  CAS  Google Scholar 

  • Loeb LA (2001) A mutator phenotype in cancer. Cancer Res 61: 3230–3239

    PubMed  CAS  Google Scholar 

  • Loveday RL, Greenman J, Simcox DL, Speirs V, Drew PJ, Monson JRT, Kerin MJ (2000) Genetic changes in breast cancer detected by comparative genomic hybridisation. Int J Cancer 86: 494–500

    Article  PubMed  CAS  Google Scholar 

  • Miyoshi Y, Iwao K, Egawa C, Noguchi S (2001) Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int J Cancer 92: 370–373

    Article  PubMed  CAS  Google Scholar 

  • Nathanson KL, Shugart YY, Omaruddin R, Szabo C, Goldgar D, Rebbeck TR, Weber BL (2002). CGH-targeted linkage analysis reveals a possible BRCA1 modifier locus on chromosome 5q. Hum Mol Genet 11: 1327–1332

    Article  PubMed  CAS  Google Scholar 

  • Nowell PC (1989) The clonal nature of neoplasia. Cancer Cells 1: 29–30

    PubMed  CAS  Google Scholar 

  • Peltomaki P (2001) Deficient DNA mismatch repair: a common etiologic factor for colon cancer. Hum Mol Genet 10: 735–740

    Article  PubMed  CAS  Google Scholar 

  • Porter D, Lahti-Domenici J, Keshaviah A et al. (2003) Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res 1: 362–75

    PubMed  CAS  Google Scholar 

  • Rennstam K, Ahlstedt-Soini M, Baldetorp B et al. (2003) Patterns of chromosomal imbalances defines subgroups of breast cancer with distinct clinical features and prognosis. A study of 305 tumors by comparative genomic hybridisation. Cancer Res 63: 8861–8868

    PubMed  CAS  Google Scholar 

  • Rice JC, Futscher BW (2000) Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter. Nucleic Acids Res 28:3233–3239

    Article  PubMed  CAS  Google Scholar 

  • Roskoski R (2004) The ErbB/HER receptor protein tyrosine kinases and cancer. Biochem Biophys Res Commun 319: 1–11

    Article  PubMed  CAS  Google Scholar 

  • Rummukainen J, Kytola S, Karhu R, Farnebo F, Larsson C, Isola JJ (2001) Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridisation, fluorescence in situ hybridization, and spectral karyotyping. Cancer Genet Cytogenet 126: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Russo G, Zegar C, Giordano A (2003) Advantages and limitations of microarray technology in human cancer. Oncogene 22: 6497–6507

    Article  PubMed  CAS  Google Scholar 

  • Simon R, Nocito A, Hübscher T et al. (2001) Patterns of HER-2/neu amplification and overexpression in primary and metastatic breast cancer. J Natl Cancer Inst 93: 1141–1146

    Article  PubMed  CAS  Google Scholar 

  • Sorlie T, Tibshirani R, Parker J et al. (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100: 8418–8423

    Article  PubMed  CAS  Google Scholar 

  • Tanner M, Järvinen P, Isola J (2001) Amplification of HER-2/neu and Topoisomerase-IIa in primary and metastatic breast cancer. Cancer Res 61: 5345–5348

    PubMed  CAS  Google Scholar 

  • Teixeira MR, Tsarouha H, Kraggerud SM et al. (2001) Evaluation of breast cancer polyclonality by combined chromosome banding and comparative genomic hybridisation analysis. Neoplasia 3: 204–214

    Article  PubMed  CAS  Google Scholar 

  • Tomlinson IPM (2001) Mutations in normal breast tissue and breast tumors. Breast Cancer Res 3: 299–303

    Article  PubMed  CAS  Google Scholar 

  • Veer van’t LJ, Dai H, Vijver van de MJ, He YD et al. (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 31:530–536

    Article  Google Scholar 

  • Wang ZC, Lin M, Wei LJ et al (2004) Loss of heterozygosity and its correlation with expression profiles in subclasses of invasive breast cancers. Cancer Res 64: 64–71

    Article  PubMed  CAS  Google Scholar 

  • Weimer J, Kiechle M, Arnold N (2000) FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements. Cytogenet Cell Genet 88: 114–118

    Article  PubMed  CAS  Google Scholar 

  • Xu X, Brodie SG, Yang X et al. (2000) Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 19: 1868–1874

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Onkologisches Labor, Universitäs-Frauenklinik, Michaelistraße 16, 24105, Kiel

    Prof. Dr. rer. nat. Norbert Arnold

Authors
  1. Prof. Dr. rer. nat. Norbert Arnold
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Arnold, N. (2006). Genetische Veränderungen des sporadischen Mammakarzinoms. In: Management des Mammakarzinoms. Onkologie aktuell. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-31748-7_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-31748-7_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-31747-0

  • Online ISBN: 978-3-540-31748-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation