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Generation of Embryonic Stem (ES) Cell-Derived Embryos and Mice by Tetraploid-Embryo Complementation

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Mammalian and Avian Transgenesis — New Approaches

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References

  • Al-Shawi R, Burke J, Wallace H, Jones C, Harrison S, Buxton D, Maley S, Chandly A, Bishop JO (1991) The herpes simplex type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter. Mol Cell Biol 11:4207–4216

    PubMed  CAS  Google Scholar 

  • Bishop CE, Hatat D (1987) Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the testis. Nucleic Acids Res 15:2959–2969

    Article  PubMed  CAS  Google Scholar 

  • Cattanach B (1962) Xo mice. Genet Res 3:487–490

    Article  Google Scholar 

  • Edwards RG (1958) Colchicine-induced heteroploidy in the mouse. ii the induction of tetraploidy and heteroploidy. J Exp Zool 137:349–362

    Article  PubMed  CAS  Google Scholar 

  • Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WM III, Yanagimachi R, Jaenisch R (2001) Hybrid vigor, fetal overgrowth, and the viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci USA 98:6209–6214

    Article  PubMed  CAS  Google Scholar 

  • Eggan K, Rode A, Jentsch I, Samuel C, Hennek T, Tintrup H, Zevnik B, Erwin J, Loring J, Jackson-Grusby L, Speicher MR, Kuehn R, Jaenisch R (2002) Male and female mice derived from the same embryonic stem clone by tetraploid embryo complementation. Nat Biotechnol 20:455–459

    Article  PubMed  CAS  Google Scholar 

  • Eggan K, Jaenisch R (2003) Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Methods Enzymol 365:25–39

    PubMed  Google Scholar 

  • Eglitis MA (1980) Formation of tetraploid mouse blastocysts following blastomere fusion with polyethylene glycol. J Exp Zool 213:309–313

    Article  PubMed  CAS  Google Scholar 

  • Hogan B, Beddington R, Constantini F, Lacy E (1994) Manipulating the mouse embryo. 2 edn Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY

    Google Scholar 

  • Laird PW, Zidjgerveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A (1991) A simplified mammalian DNA isolation procedure. Nucleic Acids Res 19:4293

    Article  PubMed  CAS  Google Scholar 

  • Lamar EE, Palmer E (1984) Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains. Cell 37:171–177

    Article  PubMed  CAS  Google Scholar 

  • Liu X, Wu H, Loring J, Hormuzdi S, Disreche CM, Bornstein P, Jaenisch R (1997) Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn 209:85–91

    Article  PubMed  CAS  Google Scholar 

  • Marahrens Y, Panning P, Dausman J, Strauss W, Jaenisch R (1997) Xist-deficient mice are defective in dosage compensation but not in spermatogenesis. Genes Dev 11:156–166

    Article  PubMed  CAS  Google Scholar 

  • Mclaughlin KJ (1993) Production of tetraploid embryos by electrofusion. Methods Enzymol 225:919–930

    Article  PubMed  CAS  Google Scholar 

  • Nagy, A., Gersenstein, M., Vintersten, K., Behringer, R. (eds) (2002) Manipulating the mouse embryo. 3 edn Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY

    Google Scholar 

  • Nagy A, Gocza E, Diaz EM, Prideaux VR, Ivanyi E, Markkula M, Rossant J (1990) Embryonic stem cells alone are able to support fetal development in the mouse. Development 110:815–821

    PubMed  CAS  Google Scholar 

  • Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC (1993) Derivation of completely cell-culture derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 90:8424–8428

    Article  PubMed  CAS  Google Scholar 

  • Rossant J, Cross JC (2001) Placental development: lessons from mouse mutants. Nat Rev Genet 2:538–548

    Article  PubMed  CAS  Google Scholar 

  • Schwenk F, Zevnik B, Bruning J, Rohl M, Willumeit A, Rode A, Hennek T, Kauselmann G, Jaenisch R, Kuhn R (2003) Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological and neurological characteristics. Mol Cell Biol 11:3982–3989

    Article  CAS  Google Scholar 

  • Seibler J, Zevnik B, Kuter-luks B, Andreas S, Kern H, Hennek T, Rode A, Heinmann C, Faust N, Kauselmann G, Schoor M, Jaenisch R, Rajewsky K, Kuhn R, Schwenk F (2003) Rapid generation of inducible mouse mutants. Nucleic Acids Res 4:e12

    Article  CAS  Google Scholar 

  • Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T (2004) Cre-lox regulated conditional RNA interference from transgenes. Proc Natl Acad Sci USA 28:10380–10385

    Article  Google Scholar 

  • Wang PJ, McCarrey JM, Yang F, Page DC (2001) An abundance of x-linked genes expressed in spermatogonia. Nat Genet 27:422–426

    Article  PubMed  CAS  Google Scholar 

  • Wang ZQ, Kiefer F, Urbanek P, Wagner EF (1997) Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection. Mech Dev 62:137–145

    Article  PubMed  CAS  Google Scholar 

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Eggan, K., Jaenisch, R. (2006). Generation of Embryonic Stem (ES) Cell-Derived Embryos and Mice by Tetraploid-Embryo Complementation. In: Pease, S., Lois, C. (eds) Mammalian and Avian Transgenesis — New Approaches. Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-28489-5_3

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