Abstract
Lab-on-a-chip assays allow rapid identification of multiple parameters on an automated user-friendly platform. Here we describe a fully automated multiplex immunoassay and readout in less than 15 min using the Fraunhofer in vitro diagnostics (ivD) platform to enable inexpensive point-of-care profiling of sera or a single drop of blood from patients with various diseases such as psychiatric disorders.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Olesen J, Gustavsson A, Svensson M, Wittchen HU, Jönsson B, CDBE2010 study group (2012) The economic cost of brain disorders in Europe. Eur J Neurol 19:155–162
Mitchell AJ, Vaze A, Rao S (2009) Clinical diagnosis of depression in primary care: a meta-analysis. Lancet 374:609–619
Bet PM, Hugtenburg JG, Penninx BW, Av B, Nolen WA, Hoogendijk WJ (2013) Treatment inadequacy in primary and specialized care patients with depressive and/or anxiety disorders. Psychiatry Res 210:594–600
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, Fifth Edition (DSM-5), 5th edn. American Psychiatric Publishing, Washington ISBN-13: 978–0890425558
Szulc A, Galińska B, Konarzewska B, Gudel-Trochimowicz I, Popławska R (2001) Immunological marker activity in first episode schizophrenic patients. Pol Merkur Lekarski 10:450–452
Van Venrooij JA, Fluitman SB, Lijmer JG, Kavelaars A, Heijnen CJ, Westenberg HG et al (2012) Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis. Schizophr Bull 38:272–279
Perkins DO, Jeffries CD, Addington J, Bearden CE, Cadenhead KS, Cannon TD et al (2014) Towards a psychosis risk blood diagnostic for persons experiencing high-risk symptoms: preliminary results from the NAPLS project. Schizophr Bull 41:419–428
Chan MK, Krebs MO, Cox D, Guest PC, Yolken RH, Rahmoune H et al (2015) Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset. Transl Psychiatry 5:e601. doi:10.1038/tp.2015.9
Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC et al (2010) Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophrenia. Biomark Insights 5:39–47
Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM et al (2012) Identification of a biological signature for schizophrenia in serum. Mol Psychiatry 17:494–502
Papakostas GI, Shelton RC, Kinrys G, Henry ME, Bakow BR, Lipkin SH et al (2013) Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a pilot and replication study. Mol Psychiatry 18:332–339
Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BW, Bahn S (2015) Discovery of serum biomarkers predicting development of a subsequent depressive episode in social anxiety disorder. Brain Behav Immun 48:123–131
Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BW, Bahn S et al (2016) Serum biomarkers predictive of depressive episodes in panic disorder. J Psychiatr Res 73:53–62
Schwarz E, Guest PC, Steiner J, Bogerts B, Bahn S (2012) Identification of blood based molecular signatures for prediction of response and relapse in schizophrenia patients. Transl Psychiatry 2:e82
Tomasik J, Schwarz E, Lago SG, Rothermundt M, Leweke FM, van Beveren NJ et al (2016) Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients. Brain Behav Immun 52:178–186
Bilello JA, Thurmond LM, Smith KM, Pi B, Rubin R, Wright SM et al (2015) MDDScore: confirmation of a blood test to aid in the diagnosis of major depressive disorder. J Clin Psychiatry 76:e199–e206
Wehler CA, Preskorn SH (2016) High false-positive rate of a putative biomarker test to aid in the diagnosis of schizophrenia. J Clin Psychiatry 77:e451–e456
https://www.aacc.org/publications/cln/articles/2016/march/the-elusive-blood-test-for-depression
http://www.youris.com/Health/Smart_Devices/Schizophrenia-Enters-The-Molecular-Diagnostics-Era.kl
Schumacher S, Nestler J, Otto T, Wegener M, Ehrentreich-Förster E, Michel D et al (2012) Highly-integrated lab-on-chip system for point-of-care multiparameter analysis. Lab Chip 12:464–473
Schumacher S, Ludecke C, Ehrentreich-Förster E, Bier FF (2013) Platform technologies for molecular diagnostics near the patient's bedside. Adv Biochem Eng Biotechnol 133:75–87
Streit P, Nestler J, Shaporin A, Schulze R, Gessner T (2016) Thermal design of integrated heating for lab-on-a-chip systems. Proceedings of the 17th international conference on thermal, mechanical and multi-physics simulation and experiments in microelectronics and microsystems (EuroSimE). pp 1–6
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Peter, H., Wienke, J., Guest, P.C., Bistolas, N., Bier, F.F. (2017). Lab-on-a-Chip Proteomic Assays for Psychiatric Disorders. In: Guest, P. (eds) Proteomic Methods in Neuropsychiatric Research. Advances in Experimental Medicine and Biology(), vol 974. Springer, Cham. https://doi.org/10.1007/978-3-319-52479-5_33
Download citation
DOI: https://doi.org/10.1007/978-3-319-52479-5_33
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-52478-8
Online ISBN: 978-3-319-52479-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)