Abstract
Reducing consumption of dietary saturated fat (SFA) has been part of dietary recommendations for many years as a means to prevent cardiovascular outcomes. Yet, recent research has challenged this very basic concept in preventive nutrition. Data have suggested that LDL-C raising effect of dietary SFA may be influenced by its dietary source, cheese having less hypercholesterolemic effects than butter. Observational cohort studies have generally failed to find significant associations between intake of SFA and risk of coronary heart disease. In large intervention studies, substituting vegetable oil rich in polyunsaturated fatty acids for SFA have not yielded consistent results in terms of cardiovascular benefits. In the end, there is no absolute consensus on the importance of SFA in a heart-healthy diet. As emphasized in this chapter, more research is required to put this debate at rest. In the mean time, focusing on whole foods and dietary patterns, without overly emphasizing the importance of SFA in the diet, seems entirely reasonable and appropriate.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Hunt CL. Food for young children. Washington, DC: US Department of Agriculture, Farmer’s Bulletin;1916. p. 717.
Gifford KD. Dietary fats, eating guides, and public policy: history, critique, and recommendations. Am J Med. 2002;113:89–106.
Mansfield HC. A short history of OPA. Washington, DC: Office of Temporary Controls OoPA; 1947. p. 332.
Welsh SO, Davis C, Shaw A. 1993. USDA’s Food Guide: Background and Development. United States Department of Agriculture. Human Nutrition Information Service. Miscellaneous Publication No. 1514. Hyattsville, MD, p 1–38.
Keys A. Diet and the epidemiology of coronary heart disease. JAMA. 1957;164:1912–9.
Aravanis C, Corcondilas A, Dontas AS, et al. Coronary heart disease in seven countries. IX. The Greek islands of Crete and Corfu. Circulation. 1970;41:I88–100.
Yerushalmy J, Hilleboe HE. Fat in the diet and mortality from heart disease; a methodologic note. NY State J Med. 1957;57:2343–54.
Committee USS. Dietary goals for the United States. US Senate Select Committee on Nutrition and Human Needs. Washington, DC; 1977.
Committee USS. Dietary goals for the United States, 2nd ed. US Senate Select Committee on Nutrition and Human Needs. Washington, DC; 1977.
Hite AH, Feinman RD, Guzman GE, et al. In the face of contradictory evidence: report of the Dietary Guidelines for Americans Committee. Nutrition. 2010;26:915–24.
Mensink RP, Zock PL, Kester ADM, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003;77:1146–55.
Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–7.
Desroches S, Lamarche B. The evolving definitions and increasing prevalence of the metabolic syndrome. Appl Physiol Nutr Metab. 2007;32:23–32.
Lamarche B, Moorjani S, Lupien PJ, et al. Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Quebec cardiovascular study. Circulation. 1996;94:273–8.
Lamarche B, Despres JP, Moorjani S, et al. Triglycerides and HDL-cholesterol as risk factors for ischemic heart disease. Results from the Quebec cardiovascular study. Atherosclerosis. 1996;119:235–45.
Gordon T, Castelli WP, Hjortland MC, et al. High density lipoprotein as a protective factor against coronary heart disease: the Framingham study. Am J Med. 1977;62:707–14.
Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109–22.
Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012;367:2089–99.
Sniderman AD, Furberg CD, Keech A, et al. Apoproteins versus lipids as indices of coronary risk and as targets for statin therapy: analysis of the evidence. Lancet. 2003;361:777–80.
Sniderman AD, Shapiro S, Marpole D, et al. Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human low density (beta) lipoproteins]. Proc Natl Acad Sci U S A. 1980;77:604–8.
Chiu S, Bergeron N, Williams PT, et al. Comparison of the DASH (Dietary Approaches to Stop Hypertension) diet and a higher-fat DASH diet on blood pressure and lipids and lipoproteins: a randomized controlled trial. Am J Clin Nutr. 2016;103:341–7.
Huth PJ, Fulgoni VL, Keast DR, et al. Major food sources of calories, added sugars, and saturated fat and their contribution to essential nutrient intakes in the U.S. diet: data from the National Health and Nutrition Examination Survey (2003–2006). Nutr J. 2013;12:116.
de Goede J, Geleijnse JM, Ding EL, Soedamah-Muthu SS. Effect of cheese consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2015;73:259–75.
Millen BE, Abrams S, Adams-Campbell L, et al. The 2015 Dietary Guidelines Advisory Committee Scientific Report: development and major conclusions. Adv Nutr. 2016;7:438–44.
Drouin-Chartier JP, Côté JA, Labonte ME, et al. Comprehensive, evidence-based review of the impact of dairy products and dairy fat on cardiometabolic risk factors. Adv Nutr. 2016. In press 2016.
(Medicine) CoQoBaSEiCDIo. Evaluation of biomarkers and surrogate endpoints in chronic disease. National Academy of Sciences; 2010.
Ramsden CE, Zamora D, Majchrzak-Hong S, et al. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968–73). BMJ. 2016;353:i1246.
Maki KC, Slavin JL, Rains TM, Kris-Etherton PM. Limitations of observational evidence: implications for evidence-based dietary recommendations. Adv Nutr. 2014;5:7–15.
Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010;91:535–46.
Chowdhury R, Warnakula S, Kunutsor S, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 2014;160:398–406.
de Oliveira Otto MC, Mozaffarian D, Kromhout D, et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2012;96:397–404.
Scarborough P, Rayner M, van Dis I, Norum K. Meta-analysis of effect of saturated fat intake on cardiovascular disease: overadjustment obscures true associations. Am J Clin Nutr. 2010;92:458–9. author reply 459.
Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2010;7:e1000252.
Ramsden CE, Zamora D, Leelarthaepin B, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013;346:e8707.
Ahmadi-Abhari S, Luben RN, Powell N, et al. Dietary intake of carbohydrates and risk of type 2 diabetes: the European Prospective Investigation into Cancer-Norfolk study. Br J Nutr. 2014;111:342–52.
Hooper L, Martin N, Abdelhamid A, Davey Smith G. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev. 2015;(6):CD011737.
Siri-Tarino PW, Chiu S, Bergeron N, Krauss RM. Saturated fats versus polyunsaturated fats versus carbohydrates for cardiovascular disease prevention and treatment. Annu Rev Nutr. 2015;35:517–43.
Drouin-Chartier JP, Brassard D, Tessier-Grenier M, et al. Systematic review of the association between dairy product consumption and risk of cardiovascular-related clinical outcomes. Adv Nutr. 2016. (In press 2016).
Hauk L. DGAC makes food-based recommendations in the 2015–2020 Dietary Guidelines for Americans. Am Fam Physician. 2016;93:525.
Disclosures
The author is Chair of Nutrition at Laval University. This Chair is supported by unrestricted endowments from Royal Bank of Canada, Pfizer, and Provigo/Loblaws. He has received funding in the last 5 years for his research from the CIHR, NSERC, Agriculture and Agrifood Canada, the Canola Council of Canada, Dairy Farmers of Canada (DFC), Dairy Research Institute (DRI), Atrium Innovations, the Danone Institute, and Merck Frosst. He has received speaker honoraria over the last 5 years from DFC and DRI. He is Chair of the Expert Scientific Advisory Panel of DFC and was a member of the ad hoc committee on saturated fat of Heart and Stroke Foundation of Canada.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Lamarche, B. (2017). Saturated Fat: Friend or Foe?. In: Rippe, J. (eds) Nutrition in Lifestyle Medicine. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-43027-0_21
Download citation
DOI: https://doi.org/10.1007/978-3-319-43027-0_21
Published:
Publisher Name: Humana Press, Cham
Print ISBN: 978-3-319-43025-6
Online ISBN: 978-3-319-43027-0
eBook Packages: MedicineMedicine (R0)