Abstract
Visual prostheses or Vision Restoration Systems (VRSs) aim to provide blind patients with useful visual information for face, shape, and object recognition, as well as reading and independent locomotion. VRS are specifically designed for patients having lost their photoreceptors. The loss of photoreceptors can either result from hereditary genetic retinal diseases such as retinitis pigmentosa or more complex diseases such as age-related macular degeneration. Visual restoration is achieved by electrically stimulating the residual retinal circuit. After successful clinical trials by others, Pixium Vision and its partners are developing two VRS solutions for blind patients: an epi-retinal and a sub-retinal approach. This chapter describes the specificities of the epi-retinal IRISTM VRS that has obtained the European CE cerfication mark, and also discuss the associated innovations developed at the Vision Institute for future VRS models.
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Bendali A, Agnes C, Meffert S, Forster V, Bongrain A, Arnault JC, Sahel JA, Offenhausser A, Bergonzo P, Picaud S. Distinctive glial and neuronal interfacing on nanocrystalline diamond. PLoS One. 2014;9:e92562.
Bendali A, Hess LH, Seifert M, Forster V, Stephan AF, Garrido JA, Picaud S. Purified neurons can survive on peptide-free graphene layers. Adv Healthc Mater. 2013;2:929–33.
Bendali A, Rousseau L, Lissorgues G, Scorsone E, Djilas M, Degardin J, Dubus E, Fouquet S, Benosman R, Bergonzo P, Sahel JA, Picaud S. Synthetic 3D diamond-based electrodes for flexible retinal neuroprostheses: model, production and in vivo biocompatibility. Biomaterials. 2015;67:73–83.
Djilas M, Oles C, Lorach H, Bendali A, Degardin J, Dubus E, Lissorgues-Bazin G, Rousseau L, Benosman R, Ieng SH, Joucla S, Yvert B, Bergonzo P, Sahel J, Picaud S. Three-dimensional electrode arrays for retinal prostheses: modeling, geometry optimization and experimental validation. J Neural Eng. 2011;8:046020.
Feucht M, Laube T, Bornfeld N, Walter P, Velikay-Parel M, Hornig R, Richard G. Development of an epiretinal prosthesis for stimulation of the human retina. Der Ophthalmologe Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 2005;102:688–91.
Hadjinicolaou AE, Leung RT, Garrett DJ, Ganesan K, Fox K, Nayagam DA, Shivdasani MN, Meffin H, Ibbotson MR, Prawer S, O’Brien BJ. Electrical stimulation of retinal ganglion cells with diamond and the development of an all diamond retinal prosthesis. Biomaterials. 2012;33:5812–20.
Hébert C, Mazellier JP, Scorsone E, Mermoux M, Bergonzo P. Boosting the electrochemical properties of diamond electrodes using carbon nanotube scaffolds. Carbon. 2014;71:27–33.
Hébert C, Scorsone E, Mermoux M, Bergonzo P. Porous diamond with high electrochemical performance. Carbon. 2015;90:102–9.
Hornig R, Laube T, Walter P, Velikay-Parel M, Bornfeld N, Feucht M, Akguel H, Rossler G, Alteheld N, Lutke Notarp D, Wyatt J, Richard G. A method and technical equipment for an acute human trial to evaluate retinal implant technology. J Neural Eng. 2005;2:S129–34.
Hornig R, Zehnder T, Velikay-Parel M, Feucht M, Richard G. The IMI retina implant system. In: Humayun M, Weiland JD, Chader G, Greenbaum E, editors. Artifical sight: basic research, biomedical engineering, and clinical advances. New York: Springer; 2007.
Humayun MS, De Juan Jr E, Weiland JD, Dagnelie G, Katona S, Greenberg R, Suzuki S. Pattern electrical stimulation of the human retina. Vision Res. 1999;39:2569–76.
Humayun MS, Dorn JD, Ahuja AK, Caspi A, Filley E, Dagnelie G, Salzmann J, Santos A, Duncan J, Dacruz L, Mohand-Said S, Eliott D, McMahon MJ, Greenberg RJ. Preliminary 6 month results from the argus II epiretinal prosthesis feasibility study. Conf Proc IEEE Eng Med Biol Soc. 2009;1:4566–8.
Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE, Cideciyan AV, Duncan JL, Eliott D, Filley E, Ho AC, Santos A, Safran AB, Arditi A, Del Priore LV, Greenberg RJ. Interim results from the international trial of second sight’s visual prosthesis. Ophthalmology. 2012;119:779–88.
Humayun MS, Prince M, De Juan Jr E, Barron Y, Moskowitz M, Klock IB, Milam AH. Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1999;40:143–8.
Ivastinovic D, Langmann G, Nemetz W, Hornig R, Richard G, Velikay-Parel M. Clinical stability of a new method for fixation and explanation of epiretinal implants. Acta Ophthalmol. 2010;88:e285–6.
Joucla S, Yvert B. Improved focalization of electrical microstimulation using microelectrode arrays: a modeling study. PLoS One. 2009;4:e4828.
Keseru M, Feucht M, Bornfeld N, Laube T, Walter P, Rossler G, Velikay-Parel M, Hornig R, Richard G. Acute electrical stimulation of the human retina with an epiretinal electrode array. Acta Ophthalmol. 2012;90:e1–8.
Lorach H, Benosman R, Marre O, Ieng SH, Sahel JA, Picaud S. Artificial retina: the multichannel processing of the mammalian retina achieved with a neuromorphic asynchronous light acquisition device. J Neural Eng. 2012;9:066004.
Lorach H, Goetz G, Smith R, Lei X, Mandel Y, Kamins T, Mathieson K, Huie P, Harris J, Sher A, Palanker D. Photovoltaic restoration of sight with high visual acuity. Nat Med. 2015;21:476–82.
Majji AB, Humayun MS, Weiland JD, Suzuki S, D’Anna SA, De Juan Jr E. Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs. Invest Ophthalmol Vis Sci. 1999;40:2073–81.
Mathieson K, Loudin J, Goetz G, Huie P, Wang L, Kamins T, Galambos L, Smith R, Harris JS, Sher A, Palanker D. Photovoltaic retinal prosthesis with high pixel density. Nat Photonics. 2012;6:391–7.
Matteucci PB, Chen SC, Tsai D, Dodds CW, Dokos S, Morley JW, Lovell NH, Suaning GJ. Current steering in retinal stimulation via a quasimonopolar stimulation paradigm. Invest Ophthalmol Vis Sci. 2013;54:4307–20.
Menzel-Severing J, Laube T, Brockmann C, Bornfeld N, Mokwa W, Mazinani B, Walter P, Roessler G. Implantation and explantation of an active epiretinal visual prosthesis: 2-year follow-up data from the EPIRET3 prospective clinical trial. Eye (Lond). 2012;26:501–9.
Palanker D, Huie P, Vankov A, Aramant R, Seiler M, Fishman H, Marmor M, Blumenkranz M. Migration of retinal cells through a perforated membrane: implications for a high-resolution prosthesis. Invest Ophthalmol Vis Sci. 2004;45:3266–70.
Piret G, Hebert C, Mazellier JP, Rousseau L, Scorsone E, Cottance M, Lissorgues G, Heuschkel MO, Picaud S, Bergonzo P, Yvert B. 3D-nanostructured boron-doped diamond for microelectrode array neural interfacing. Biomaterials. 2015;53:173–83.
Posch C, Matolin D, Wohlgenannt R. A QVGA 143 dB dynamic range frame-free PWM image sensor with lossless pixel-level video compression and time-domain CDS. Solid-State Circuits IEEE J. 2011;46:259–75.
Posch C, Serrano-Gotarredona T, Linares-Barranco B, Delbruck T. Retinomorphic event-based vision sensors: bioinspired cameras with spiking output. Proc IEEE. 2014;102:1470–84.
Richard G, Feucht M, Bornfeld N, Laube T, Rössler G, Velikay-Parel M, Hornig R. Multicenter study on acute electrical stimulation of the human retina with an epiretinal implant: clinical results in 20 patients. Invest Ophthalmol Vis Sci. 2005;46:1143.
Richard G, Keserue M, Zeitz O, Hornig R. Surgical aspects of a long-term implantation of a wireless chip in blind patients. I. In: Proceedings 9th EURETINA Congress Nice from 14 to 17 May 2009. p. 6:8–6:10.
Walter P, Szurman P, Vobig M, Berk H, Ludtke-Handjery HC, Richter H, Mittermayer C, Heimann K, Sellhaus B. Successful long-term implantation of electrically inactive epiretinal microelectrode arrays in rabbits. Retina (Philadelphia Pa). 1999;19:546–52.
Zrenner E, Bartz-Schmidt KU, Benav H, Besch D, Bruckmann A, Gabel VP, Gekeler F, Greppmaier U, Harscher A, Kibbel S, Koch J, Kusnyerik A, Peters T, Stingl K, Sachs H, Stett A, Szurman P, Wilhelm B, Wilke R. Subretinal electronic chips allow blind patients to read letters and combine them to words. Proc R Soc. 2011;B 278:1489–97.
Acknowledgements
The Vision Institute was supported by INSERM, UPMC (Paris VI), Foundation Fighting Blindness, the Fédération des Aveugles de France, Fondation de la Recherche Médicale (grant number DBC20101021013), the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 280433 (Neurocare project) and under the Graphene Flagship (Contract N° 604391), the LabEx LIFESENSES (ANR-10-LABX-65), which was supported by French state funds managed by the ANR within the Investissements d’Avenir programme (ANR-11-IDEX-0004-02).
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Hornig, R. et al. (2017). Pixium Vision: First Clinical Results and Innovative Developments. In: Gabel, V. (eds) Artificial Vision. Springer, Cham. https://doi.org/10.1007/978-3-319-41876-6_8
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DOI: https://doi.org/10.1007/978-3-319-41876-6_8
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