Skip to main content

Ordinal Evolutionary Artificial Neural Networks for Solving an Imbalanced Liver Transplantation Problem

  • Conference paper
  • First Online:
Book cover Hybrid Artificial Intelligent Systems (HAIS 2016)

Abstract

Ordinal regression considers classification problems where there exists a natural ordering among the categories. In this learning setting, thresholds models are one of the most used and successful techniques. On the other hand, liver transplantation is a widely-used treatment for patients with a terminal liver disease. This paper considers the survival time of the recipient to perform an appropriate donor-recipient matching, which is a highly imbalanced classification problem. An artificial neural network model applied to ordinal classification is used, combining evolutionary and gradient-descent algorithms to optimize its parameters, together with an ordinal over-sampling technique. The evolutionary algorithm applies a modified fitness function able to deal with the ordinal imbalanced nature of the dataset. The results show that the proposed model leads to competitive performance for this problem.

This work has been subsidized by the TIN2014-54583-C2-1-R project of the Spanish Ministerial Commission of Science and Technology (MICYT), FEDER funds and the P2011-TIC-7508 project of the “Junta de Andalucía” (Spain). The authors M. Dorado-Moreno, M. Pérez-Ortíz and M.D. Ayllón-Terán have contributed equally to the preparation of this paper.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Breiman, L.: Statistical modeling: The two cultures. Stat. Sci. 16(3), 199–231 (2001)

    Article  MathSciNet  MATH  Google Scholar 

  2. Kotsiantis, S.B., Zaharakis, I.D., Pintelas, P.E.: Machine learning: a review of classification and combining techniques. Artif. Intell. Rev. 26(3), 159–190 (2006)

    Article  Google Scholar 

  3. Yardimci, A.: Soft computing in medicine. Appl. Soft Comput. 9(3), 1029–1043 (2009)

    Article  Google Scholar 

  4. Li, W., Coats, M., Zhang, J., McKenna, S.J.: Discriminating dysplasia: Optical tomographic texture analysis of colorectal polyps. Med. Image Anal. 26, 57–69 (2015)

    Article  Google Scholar 

  5. Jimenez, F., Sanchez, G., Juarez, J.M.: Multi-objective evolutionary algorithms for fuzzy classification in survival prediction. Artif. Intell. Med. 60, 197–219 (2014)

    Article  Google Scholar 

  6. Gooleyand, T.A., Chienand, J.W., Pergamand, S.A., Hingoraniand, S., Sorrorand, M.L., Boeckhand, M., Martinand, P.J., Sandmaierand, B.M., Marrand, K.A., Appelbaumand, F.R., Storband, R., McDonaldand, G.B.: Reduced mortality after allogeneic hematopoietic-cell transplantation. N. Engl. J. Med. 363(22), 2091–2101 (2010)

    Article  Google Scholar 

  7. Mazzaferro, V., Llovet, J.M., Miceli, R., et al.: Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the milan criteria: a retrospective, exploratory analysis. Lancet Oncol. 10, 30–43 (2009)

    Google Scholar 

  8. Delen, D., Oztekin, A., Kong, Z.: A machine learning-based approach to prognostic analysis of thoracic transplantations. Artif. Intell. Med. 49, 33–42 (2010)

    Article  Google Scholar 

  9. Shouval, R., Bondi, O., Mishan, H., Shimoni, A., Unger, R., Nagler, A.: Application of machine learning algorithms for clinical predictive modeling: a data-mining approach in SCT. Bone Marrow Transplant. 49, 332–337 (2014)

    Article  Google Scholar 

  10. Shouval, R., Labopin, M., Bondi, O., Mishan-Shamay, H., et al.: Prediction of allogeneic hematopoietic stem-cell transplantation mortality 100 days after transplantation using a machine learning algorithm: A european group for blood and marrow transplantation acute leukemia working party retrospective data mining study. J. Clin. Oncol. 33(28), 3144–3151 (2015)

    Article  Google Scholar 

  11. Pérez-Ortiz, M., Cruz-Ramírez, M., Ayllón-Terán, M., Heaton, N., Ciria, R., Hervás-Martínez, C.: An organ allocation system for liver transplantation based on ordinal regression. Appl. Soft Comput. 14, 88–98 (2014)

    Article  Google Scholar 

  12. Cruz-Ramírez, M., Hervás-Martínez, C., Gutiérrez, P.A., Pérez-Ortiz, M., Briceño, J., de la Mata, M.: Memetic Pareto differential evolutionary neural network used to solve an unbalanced liver transplantation problem. Soft. Comput. 17, 275–284 (2012)

    Article  Google Scholar 

  13. Pérez-Ortiz, M., Gutiérrez, P.A., Hervás-Martínez, C., Briceño, J., de la Mata, M.: An ensemble approach for ordinal threshold models applied to liver transplantation. In: Proceedings of the the 2012 International Joint Conference on Neural Networks (IJCNN), pp. 2795–2802 (2012)

    Google Scholar 

  14. Gutiérrez, P.A., Pérez-Ortiz, M., Sánchez-Monedero, J., Fernandez-Navarro, F., Hervás-Martínez, C.: Ordinal regression methods: survey and experimental study. IEEE Trans. Knowl. Data Eng. 28, 127–146 (2015)

    Article  Google Scholar 

  15. Sun, B.Y., Li, J., Wu, D.D., Zhang, X.M., Li, W.B.: Kernel discriminant learning for ordinal regression. IEEE Trans. Knowl. Data Eng. 22, 906–910 (2010)

    Article  Google Scholar 

  16. McCullagh, P.: Regression models for ordinal data. J. Roy. Stat. Soc. B (Methodol.) 42(2), 109–142 (1980)

    MathSciNet  MATH  Google Scholar 

  17. Agresti, A.: Analysis of Ordinal Categorical Data. Wiley series in probability and mathematical statistics. Applied probability and statistics. Wiley, Chichester (1984)

    MATH  Google Scholar 

  18. Chapron, C., Fauconnier, A., Dubuisson, J.B., Barakat, H., Vieira, M., Breart, G.: Deep infilltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease. Hum. Reprod. 18(4), 760–766 (2003)

    Article  Google Scholar 

  19. Feldmann, U., Steudel, I.: Methods of ordinal classification applied to medical scoring systems. Stat. Med. 19, 575–586 (2000)

    Article  Google Scholar 

  20. LeBlanc, M., Beaulieu-Bonneau, S., Merette, C., Savard, J., Ivers, H., Morin, C.M.: Psychological and health-related quality of life factors associated with insomnia in a population-based sample. J. Psychosom. Res. 63, 157–166 (2007)

    Article  Google Scholar 

  21. He, H., Garcia, E.A.: Learning from imbalanced data. IEEE Trans. Knowl. Data Eng. 21(9), 1263–1284 (2009)

    Article  Google Scholar 

  22. Japkowicz, N., Stephen, S.: The class imbalance problem: a systematic study. Intell. Data Anal. 6(5), 429–449 (2002)

    MATH  Google Scholar 

  23. Galar, M., Fernández, A., Barrenechea, E., Bustince, H., Herrera, F.: A review on ensembles for the class imbalance problem: bagging-, boosting-, and hybrid-based approaches. IEEE Trans. Syst. Man Cybern. Part C: Appl. Rev. 42(4), 463–484 (2012)

    Article  Google Scholar 

  24. Pérez-Ortiz, M., Gutiérrez, P., Hervás-Martínez, C., Yao, X.: Graph-based approaches for over-sampling in the context of ordinal regression. IEEE Trans. Knowl. Data Eng. 27(5), 1233–1245 (2015)

    Article  Google Scholar 

  25. Dorado-Moreno, M., Gutiérrez, P.A., Hervás-Martínez, C.: Ordinal classification using hybrid artificial neural networks with projection and kernel basis functions. In: Corchado, E., Snášel, V., Abraham, A., Woźniak, M., Graña, M., Cho, S.-B. (eds.) HAIS 2012, Part II. LNCS, vol. 7209, pp. 319–330. Springer, Heidelberg (2012)

    Chapter  Google Scholar 

  26. Hsu, C.W., Lin, C.J.: A comparison of methods for multi-class support vector machines. IEEE Trans. Neural Netw. 13(2), 415–425 (2002)

    Article  Google Scholar 

  27. Deng, W.Y., Zheng, Q.H., Lian, S., Chen, L., Wang, X.: Ordinal extreme learning machine. Neurocomputing 74(1–3), 447–456 (2010)

    Article  Google Scholar 

  28. Lin, H.T., Li, L.: Reduction from cost-sensitive ordinal ranking to weighted binary classification. Neural Comput. 24(5), 1329–1367 (2012)

    Article  MATH  Google Scholar 

  29. Baccianella, S., Esuli, A., Sebastiani, F.: Evaluation measures for ordinal regression. In: Proccedings of the Ninth International Conference on Intelligent Systems Design and Applications, ISDA 2009, pp. 283–287 (2009)

    Google Scholar 

  30. Fernández, A., García, S., del Jesus, M.J., Herrera, F.: A study of the behaviour of linguistic fuzzy rule based classification systems in the framework of imbalanced data-sets. Fuzzy Sets Syst. 159(18), 2378–2398 (2008)

    Article  MathSciNet  Google Scholar 

  31. Fernández-Navarro, F., Hervás-Martínez, C., Antonio Gutiérrez, P.: A dynamic over-sampling procedure based on sensitivity for multi-class problems. Pattern Recogn. 44(8), 1821–1833 (2011)

    Article  MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manuel Dorado-Moreno .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this paper

Cite this paper

Dorado-Moreno, M., Pérez-Ortiz, M., Ayllón-Terán, M.D., Gutiérrez, P.A., Hervás-Martínez, C. (2016). Ordinal Evolutionary Artificial Neural Networks for Solving an Imbalanced Liver Transplantation Problem. In: Martínez-Álvarez, F., Troncoso, A., Quintián, H., Corchado, E. (eds) Hybrid Artificial Intelligent Systems. HAIS 2016. Lecture Notes in Computer Science(), vol 9648. Springer, Cham. https://doi.org/10.1007/978-3-319-32034-2_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-32034-2_38

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32033-5

  • Online ISBN: 978-3-319-32034-2

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics