Abstract
Ischemia of the extremities is a fairly common clinical entity most commonly caused by occlusive arteriosclerotic disease with secondary thrombosis or embolization. The resultant ischemic extremity will present with progressive pain syndromes and pregangrenous or gangrenous tissue. When the disease progresses beyond survivability and the symptomatology is unbearable, amputation is necessitated. The pathologist then receives the premorbid or neurotic tissue after removal.
Other diseases, besides the arteriosclerotic occlusions, are seen on occasion producing severe limb ischemia. Raynaud’s disease, Buerger’s disease (thromboangiitis obliterans), and Behcet’s disease are lesser causes for these changes as well as coagulation abnormalities. Even embolic syndromes due to tumor, foreign bodies, or thrombus at surgery may be present in addition to Heyde’s syndrome secondary to aortic valve disease.
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Roscher, A.A., Dieter, R.A., Johnson, B.L. (2017). Pathologic Aspects of Ischemic Limb Disease. In: Dieter, R., Dieter, Jr, R., Dieter, III, R., Nanjundappa, A. (eds) Critical Limb Ischemia. Springer, Cham. https://doi.org/10.1007/978-3-319-31991-9_4
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DOI: https://doi.org/10.1007/978-3-319-31991-9_4
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