Chapter

Stretchable Bioelectronics for Medical Devices and Systems

Part of the series Microsystems and Nanosystems pp 275-291

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In Vitro Neural Recording by Microelectrode Arrays

  • Hongki KangAffiliated withDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)
  • , Yoonkey NamAffiliated withDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST) Email author 

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Abstract

Neural interface plays an important role in monitoring and modulating brain activity. In order to study the neural information processing in vitro, microelectrode array (MEA) platform is used with cell culture or brain slice. To measure neural signals simultaneously from multiple cells for long-term period, extracellular neural recording technique is preferred and subcellular-scale microelectrodes , dense array, and flexible substrates are ideal. In this chapter, we will introduce the state-of-the-art in vitro neural recording technology based on microfabricated electrodes or transistors. MEAs with metal-type microelectrodes are passive types, and MEAs with active electronic components (field-effect transistors or integrated circuits) are active types. The motivation, operation principles, fabrication processes and materials, and current trends are reviewed.

Keywords

Microelectrode array (MEA) Neural interface Neural recording Action potentials Extracellular recording