Abstract
Chronic pancreatitis (CP) is a process characterized by inflammatory destruction of pancreatic parenchyma and ductal structures with formation of fibrosis. Patients complain of pain as the predominant symptom of CP. Treatment is directed towards symptoms and management of the structural complications—stones, pancreatic ductal strictures, duct leaks, pseudocysts, and associated biliary strictures. Medical therapies such as abstinence from alcohol, dietary alterations, analgesics, oral enzyme supplements, and somatostatin analogs are only partially effective in relieving pain. Endoscopic therapy for CP was introduced more than 15 years ago. Endoscopic therapy as first line therapy may reduce or eliminate the need for surgical procedures, may serve as a bridge to surgery and can predict the response to surgical therapy. If endoscopic therapy is unsuccessful, surgical therapy is still an option for most patients. The aim of endoscopic therapy in patients with CP is to alleviate outflow obstruction of the biliary or pancreatic secretions. Endoscopic therapy using Endoscopic Retrograde Cholangiography (ERCP) should be considered in conjunction with medical, surgical, and percutaneous approaches. This chapter reviews the current role of ERCP in management of chronic pancreatitis.
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References
Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120(3):682–707.
EnrĂquez WK. Diagnostic and therapeutic endoscopy of pancreas and biliary tract. Rev Gastroenterol Mex. 2006;71 Suppl 1:36–8.
Kahl S, Glasbrenner B, Leodolter A, Pross M, Schulz HU, Malfertheiner P. EUS in the diagnosis of early chronic pancreatitis: a prospective follow-up study. Gastrointest Endosc. 2002;55:507–11.
Freeman ML. Adverse outcomes of ERCP. Gastrointest Endosc. 2002;56(6 Suppl):S273–82.
Sarner M, Cotton PB. Classification of pancreatitis. Gut. 1984;25(7):756–9.
Gabbrielli A, Mutigani M, Pondolfi M, Perri V, Costamagna G. Endotherapy of early onset idiopathic chronic pancreatitis: results with long-term follow-up. Gastrointestinal Endosc. 2002;55(4):488–93.
Ell C, Rabinstein T, Bulling D. Safety and efficacy of pancreatic sphincterotomy in chronic pancreatitis. Gastrointestinal Endosc. 1998;48(3):244–9.
Varadarajulu S, Mel Wilcox C. Randomized trial comparing needle-knife and pull-sphincterotome techniques for pancreatic sphincterotomy in high-risk patients. Gastrointest Endosc. 2006;64(5):716–22.
Freeman ML, DiSario JA, Nelson DB, Fennerty MB, Lee JG, Bjorkman DJ, et al. Risk factors for post-ERCP pancreatitis: a prospective, multicenter study. Gastrointest Endosc. 2001;54(4):425–34.
Vandervoort J, Soetikno RM, Tham TCK, Wong RCK, Ferrari Jr AP, Montes H, et al. Risk factors for complications after performance of ERCP. Gastrointest Endosc. 2002;56(5):652–6.
Gottlieb K, Sherman S. ERCP and endoscopic biliary sphincterotomy-induced pancreatitis. Gastrointest Endosc Clin N Am. 1998;8:87–114.
Hookey L, Tinto R, Delhaye M, Baize M, Le Moine O, Devière J. Risk factors for pancreatitis after pancreatic sphincterotomy: a review of 572 cases. Endoscopy. 2006;38(7):670–6.
Klibansky DA, Gordon SR, Gardner TB. Rectal indomethacin for the prevention of post-ERCP pancreatitis: a valuable tool to keep in your back pocket. Gastroenterology. 2012;143(5):1387–8.
Rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med 2012;367(3):277–9.
Kozarek RA, Ball TJ, Patterson DJ, Brandabur JJ, William Traverso L, Raltz S. Endoscopic pancreatic duct sphincterotomy: indications, technique, and analysis of results. Gastrointest Endosc. 1994;40(5):592–8.
Siegel JH, Cohen SA. Pull or push pancreatic sphincterotomy for sphincter of Oddi dysfunction? A conundrum for experts only. Gastrointestinal Endosc. 2006;64(5):723–5.
Kim MH, Myung SJ, Kim YS, Kim HJ, Seo DW, Nam SW, Ahn JH, Lee SK, Min YI. Routine biliary sphincterotomy may not be indispensable for endoscopic pancreatic sphincterotomy. Endoscopy. 1998;30:697–701.
Cotton PB. Duodenoscopic papillotomy at the minor papilla for recurrent dorsal pancreatitis. Endosc Digest. 1978;3:27–8.
Vitale GC, Vitale M, Vitale DS, Binford JC, Hill B. Long-term follow-up of endoscopic stenting in patients with chronic pancreatitis secondary to pancreas divisum. Surg Endosc. 2007;21:2199–202.
Watkins JL, Lehman GA. Minor papilla endoscopic sphincterotomy. In: Kozareck R, Carr-Lock DL, Baron TH, editors. ERCP. Amsterdam: Elsevier; 2008. p. 143–57.
Lehman GA, Sherman S, Nisi R, Hawes RH. Pancreas divisum: results of minor papilla sphincterotomy. Gastrointest Endosc. 1993;39:1–8.
Attwell A, Borak G, Hawes R, Cotton P, Romagnuolo J. Endoscopic pancreatic sphincterotomy for pancreas divisum by using a needle-knife or standard pull-type technique: safety and reintervention rates. Gastrointest Endosc. 2006;64:705–11.
Howell DA, Holbrook RF, Bosco JJ, Muggia RA, Biber BP. Endoscopic needle localization of pancreatic pseudocysts before transmural drainage. Gastrointest Endosc. 1993;39:693–8.
Elton E, Howell DA, Parsons WG, Qaseem T, Hanson BL. Endoscopic pancreatic sphincterotomy: indications, outcome, and a safe stentless technique. Gastrointest Endosc. 1998;47:240–9.
Cremer M, Deviere J. Chronic pancreatitis. In: Testoni PA, Tittobello A, editors. Endoscopy in pancreatic disease: diagnosis and therapy. Chicago: Mosby-Wolfe; 1997. p. 99–112.
Shields SJ, Carr-Locke DL. Sphincterotomy techniques and risks. Gastrointest Endosc Clin N Am. 1996;6:17–42.
Cotton PB, Williams CB. Practical gastrointestinal endoscopy. 3rd ed. London: Blackwell; 1990. p. 118–56.
Delhaye M, Matos C, Devière J. Endoscopic management of chronic pancreatitis. Gastrointest Endosc Clin N Am. 2003;13:717–42.
Maydeo A, Borkar D. Techniques of selective cannulation and sphincterotomy. Endoscopy. 2003;35:S19–23.
Freeman ML, Guda NM. ERCP cannulation: a review of reported techniques. Gastrointest Endosc. 2005;61:112–25.
Novack DJ, Al-Kawas F. Endoscopic management of bile duct obstruction and sphincter of Oddi dysfunction. In: Bayless TM, Diehl AM, editors. Advanced therapy in gastroenterology and liver disease. Hamilton: B.C. Decker; 2005. p. 766–73.
Sherman S, Lehman GA, Hawes RH, et al. Pancreatic ductal stones: frequency of successful endoscopic removal and improvement in symptoms. Gastrointest Endosc. 1991;37:511–7.
Adamek HE, Jakobs R, Buttmann A, Adamek MU, Schneider AR, Riemann JF. Long term follow up of patients with chronic pancreatitis and pancreatic stones treated with extracorporeal shock wave lithotripsy. Gut. 1999;45:402–5.
Delhaye M, Arvanitakis M, Verset G, Cremer M, Deviere J. Long-term clinical outcome after endoscopic pancreatic ductal drainage for patients with painful chronic pancreatitis. Clin Gastroenterol Hepatol. 2004;2:1096–106.
Guda NM, Freeman ML, Smith C. Role of extracorporeal shock wave lithotripsy in the treatment of pancreatic stones. Rev Gastroenterol Disord. 2005;5:73–81.
Morgan DE, Smith JK, Hawkins K, et al. Endoscopic stent therapy in advanced chronic pancreatitis: relationships between ductal changes, clinical response, and stent patency. Am J Gastroenterol. 2003;98:821–6.
Binmoeller KF, Jue P, Seifert H, et al. Endoscopic pancreatic stent drainage in chronic pancreatitis and a dominant stricture: long-term results. Endoscopy. 1995;27:638–44.
Cahen DL, Gouma DJ, Huibregtse K, Bruno MJ. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N Engl J Med. 2007;356(7):676–84.
Tandan M, Reddy DN, Santosh D, Vinod K, Ramchandani M, Rajesh G, Rama K, Lakhtakia S, Banerjee R, Pratap N, et al. Extracorporeal shock wave lithotripsy and endotherapy for pancreatic calculi-a large single center experience. Indian J Gastroenterol. 2010;29:143–8.
Adler DG, Lichtenstein D, Baron TH, Davila R, Egan JV, Gan SL, Qureshi WA, Rajan E, Shen B, Zuckerman MJ, et al. The role of endoscopy in patients with chronic pancreatitis. Gastrointest Endosc. 2006;63:933–7.
Delhaye M, Matos C, Devière J. Endoscopic technique for the management of pancreatitis and its complications. Best Pract Res Clin Gastroenterol. 2004;18:155–81.
Eleftherladis N, Dinu F, Delhaye M, Le Moine O, Baize M, Vandermeeren A, Hookey L, Devière J. Long-term outcome after pancreatic stenting in severe chronic pancreatitis. Endoscopy. 2005;37:223–30.
Costamagna G, Bulajic M, Tringali A, Pandolfi M, Gabbrielli A, Spada C, Petruzziello L, Familiari P, Mutignani M. Multiple stenting of refractory pancreatic duct strictures in severe chronic pancreatitis: long-term results. Endoscopy. 2006;38:254–9.
Kozarek RA. Pancreatic stents can induce ductal changes consistent with chronic pancreatitis. Gastrointest Endosc. 1990;36:93–5.
Tringali A, Boskoski I, Costamagna G. The role of endoscopy in the therapy of chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2008;22:145–65.
Raju GS, Gomez G, Xiao SY, Ahmed I, Brining D, Bhutani MS, Kalloo AN, Pasricha PJ. Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model. Endoscopy. 2006;38:260–5.
Ishihara T, Yamaguchi T, Seza K, Tadenuma H, Saisho H. Efficacy of s-type stents for the treatment of the main pancreatic duct stricture in patients with chronic pancreatitis. Scand J Gastroenterol. 2006;41:744–50.
Park do H, Kim MH, Moon SH, Lee SS, Seo DW, Lee SK. Feasibility and safety of placement of a newly designed, fully covered self-expandable metal stent for refractory benign pancreatic ductal strictures: a pilot study (with video). Gastrointest Endosc. 2008;68:1182–9.
Moon SH, Kim MH, Park do H, Song TJ, Eum J, Lee SS, Seo DW, Lee SK. Modified fully covered self-expandable metal stents with antimigration features for benign pancreatic-duct strictures in advanced chronic pancreatitis, with a focus on the safety profile and reducing migration. Gastrointest Endosc. 2010;72:86–91.
Dumonceau JM, Delhaye M, Tringali A, Dominguez-Munoz JE, Poley JW, Arvanitaki M, Costamagna G, Costea F, Devière J, Eisendrath P, et al. Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2012;44:784–800.
Telford JJ, Farrell JJ, Saltzman JR, Shields SJ, Banks PA, Lichtenstein DR, Johannes RS, Kelsey PB, Carr-Locke DL. Pancreatic stent placement for duct disruption. Gastrointest Endosc. 2002;56:18–24.
Adler DG, Baron TH, Davila RE, Egan J, Hirota WK, Leighton JA, et al. ASGE guideline: the role of ERCP in diseases of the biliary tract and the pancreas. Gastrointest Endosc. 2005;62(1):1–8.
Seicean A, Vultur S. Endoscopic therapy in chronic pancreatitis: current perspectives. Clin Exp Gastroenterol. 2015;8:1–11. doi:10.2147/CEG.S43096.
Lehman GA. Role of ERCP and other endoscopic modalities in chronic pancreatitis. Gastrointest Endosc. 2002;56(6 Suppl):S237–40.
Andrén-Sandberg A, Dervenis C. Pancreatic pseudocysts in the 21st century. Part I: classification, pathophysiology, anatomic considerations and treatment. JOP. 2004;5:8–24.
Lerch MM, Stier A, Wahnschaffe U, Mayerle J. Pancreatic pseudocysts: observation, endoscopic drainage, or resection? Dtsch Arztebl Int. 2009;106:614–21.
Andrén-Sandberg A, Dervenis C. Pancreatic pseudocysts in the 21st century. Part II: natural history. JOP. 2004;5:64–70.
Beckingham IJ, Krige JE, Bornman PC, Terblanche J. Endoscopic management of pancreatic pseudocysts. Br J Surg. 1997;84:1638–45.
Cahen D, Rauws E, Fockens P, Weverling G, Huibregtse K, Bruno M. Endoscopic drainage of pancreatic pseudocysts: long-term outcome and procedural factors associated with safe and successful treatment. Endoscopy. 2005;37:977–83.
Balachandra S, Siriwardena AK. Systematic appraisal of the management of the major vascular complications of pancreatitis. Am J Surg. 2005;190:489–95.
Varadarajulu S, Trevino J, Wilcox CM, Sutton B, Christein JD. Randomized trial comparing EUS and surgery for pancreatic pseudocyst drainage. Gastrointest Endosc. 2010;71:AB116.
Hookey LC, Debroux S, Delhaye M, Arvanitakis M, Le Moine O, Devière J. Endoscopic drainage of pancreatic-fluid collections in 116 patients: a comparison of etiologies, drainage techniques, and outcomes. Gastrointest Endosc. 2006;63:635–43.
Banerjee S, Shen B, Baron TH, Nelson DB, Anderson MA, Cash BD, Dominitz JA, Gan SI, Harrison ME, Ikenberry SO, et al. Antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc. 2008;67:791–8.
Barthet M, Bernard JP, Duval JL, Affriat C, Sahel J. Biliary stenting in benign biliary stenosis complicating chronic calcifying pancreatitis. Endoscopy. 1994;26:569–72.
Kahl S, Zimmermann S, Genz I, Glasbrenner B, Pross M, Schulz HU, Mc Namara D, Schmidt U, Malfertheiner P. Risk factors for failure of endoscopic stenting of biliary strictures in chronic pancreatitis: a prospective follow-up study. Am J Gastroenterol. 2003;98:2448–53.
Catalano MF, Linder JD, George S, Alcocer E, Geenen JE. Treatment of symptomatic distal common bile duct stenosis secondary to chronic pancreatitis: comparison of single vs. multiple simultaneous stents. Gastrointest Endosc. 2004;60:945–52.
Cahen DL, Rauws EA, Gouma DJ, Fockens P, Bruno MJ. Removable fully covered self-expandable metal stents in the treatment of common bile duct strictures due to chronic pancreatitis: a case series. Endoscopy. 2008;40:697–700.
Behm B, Brock A, Clarke BW, Ellen K, Northup PG, Dumonceau JM, Kahaleh M. Partially covered self-expandable metallic stents for benign biliary strictures due to chronic pancreatitis. Endoscopy. 2009;41:547–51.
Deviere JM, Reddy DN, Puspok A, Ponchon T, Bruno MJ, Bourke MJ, Neuhaus H, Roy A, González-Huix F, Barkun AN, et al. 147 Preliminary results from a 187 patient multicenter prospective trial using metal stents for treatment of benign biliary strictures. Gastrointest Endosc. 2012;75:AB123.
Familiari P, Boškoski I, Bove V, Costamagna G. ERCP for biliary strictures associated with chronic pancreatitis. Gastrointest Endosc Clin N Am. 2013;23(4):833–45.
Smits ME, Badiga SM, Rauws EAJ, et al. Long-term results of pancreatic stents in chronic pancreatitis. Gastrointest Endosc. 1995;42:461–7.
Topazian M, Aslanian H, Andersen D. Outcome following endoscopic stenting of pancreatic duct strictures in chronic pancreatitis. J Clin Gastroenterol. 2005;39:908–11.
Dite P, Ruzicka M, Zboril V, et al. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis. Endoscopy. 2003;35:553–8.
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Demonstrating key procedures in management of chronic pancreatitis. Pancreatic and biliary cannulation, sphincterotomy, stenting and dilation, drainage of pancreatic fluid collections. (65,945 kb)
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Joshi, V., Alder, L. (2016). ERCP in Patients with Chronic Pancreatitis. In: Adler, D. (eds) Advanced Pancreaticobiliary Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-319-26854-5_3
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