AxTract: Microstructure-Driven Tractography Based on the Ensemble Average Propagator

  • Gabriel Girard
  • Rutger Fick
  • Maxime Descoteaux
  • Rachid Deriche
  • Demian Wassermann
Conference paper

DOI: 10.1007/978-3-319-19992-4_53

Part of the Lecture Notes in Computer Science book series (LNCS, volume 9123)
Cite this paper as:
Girard G., Fick R., Descoteaux M., Deriche R., Wassermann D. (2015) AxTract: Microstructure-Driven Tractography Based on the Ensemble Average Propagator. In: Ourselin S., Alexander D., Westin CF., Cardoso M. (eds) Information Processing in Medical Imaging. IPMI 2015. Lecture Notes in Computer Science, vol 9123. Springer, Cham

Abstract

We propose a novel method to simultaneously trace brain white matter (WM) fascicles and estimate WM microstructure characteristics. Recent advancements in diffusion-weighted imaging (DWI) allow multi-shell acquisitions with b-values of up to 10,000 \(\mathrm{s/mm^2}\) in human subjects, enabling the measurement of the ensemble average propagator (EAP) at distances as short as 10 \(\mathrm{\mu m}\). Coupled with continuous models of the full 3D DWI signal and the EAP such as Mean Apparent Propagator (MAP) MRI, these acquisition schemes provide unparalleled means to probe the WM tissue in vivo. Presently, there are two complementary limitations in tractography and microstructure measurement techniques. Tractography techniques are based on models of the DWI signal geometry without taking specific hypotheses of the WM structure. This hinders the tracing of fascicles through certain WM areas with complex organization such as branching, crossing, merging, and bottlenecks that are indistinguishable using the orientation-only part of the DWI signal. Microstructure measuring techniques, such as AxCaliber, require the direction of the axons within the probed tissue before the acquisition as well as the tissue to be highly organized. Our contributions are twofold. First, we extend the theoretical DWI models proposed by Callaghan et al. to characterize the distribution of axonal calibers within the probed tissue taking advantage of the MAP-MRI model. Second, we develop a simultaneous tractography and axonal caliber distribution algorithm based on the hypothesis that axonal caliber distribution varies smoothly along a WM fascicle. To validate our model we test it on in-silico phantoms and on the HCP dataset.

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Gabriel Girard
    • 1
    • 2
  • Rutger Fick
    • 1
  • Maxime Descoteaux
    • 2
  • Rachid Deriche
    • 1
  • Demian Wassermann
    • 1
  1. 1.Athena Project-TeamINRIA Sophia Antipolis - MéditerranéeSophia AntipolisFrance
  2. 2.Sherbrooke Connectivity Imaging Lab (SCIL) Computer Science DepartmentUniversité de SherbrookeSherbrookeCanada

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